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SARS-CoV-2 evolutionary trends provide insights into its adaptive process to human hosts

The loss of genome heterogeneity in CoVs leads to high viral fitness variants that adapt to the human host.

31 May 2022

The role of pyroptosis in COVID-19

Researchers investigate the mechanisms by which SARS-CoV-2 induces NLRP3 inflammasome formation leading to pyroptosis.

25 May 2022

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Small interfering RNAs, or siRNAs, hold promise to treat tumors, through their ability to specifically knock down oncogenes that promote tumor growth, without the toxicity that accompanies chemotherapy. However, the siRNAs need a delivery vehicle to protect them from degradation and clearance on their journey through the bloodstream to the cancer tumor.

25 May 2022

Computational modeling fine tunes RBD-1C aptamer against SARS-CoV-2 S protein

Researchers used the SARS-CoV-2 sequence against aptamers to perform the in silico selection of an aptamer against the SARS-CoV-2 S protein.

24 May 2022

Study explores the substrate selectivity of the SARS-CoV-2 replicase

Researchers explored factors affecting substrate selection by the SARS-CoV-2 replicase.

24 May 2022

Scientists discover how immune proteins defend plants against invading microorganisms

Scientists from the Max Planck Institute for Plant Breeding Research and the University of Cologne, Germany, have discovered a novel biochemical mechanism explaining how immune proteins defend plants against invading microorganisms.

20 May 2022

CDC study reveals hybrid SARS-CoV-2 spike from Delta/Omicron recombination event

The US Centers for Disease Control and Prevention (CDC) has conducted national-level genomic surveillance to identify and characterize delta-omicron recombinant genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A total of nine genomes with a hybrid delta-omicron spike protein have been identified.

14 May 2022

Repeated DNA sequences in the genome may contribute to schizophrenia risk

Researchers at The Hospital for Sick Children (SickKids) and Centre for Addiction and Mental Health (CAMH) have found that repeated DNA sequences in the genome may contribute to an individual's risk of developing schizophrenia.

12 May 2022

The promise of RNA medicine is targeted and personalized

The development of messenger RNA (mRNA) vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has only increased the impetus in this field.

11 May 2022

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

Researchers investigated COVID-19-triggered changes in the levels of cyclins and cyclin-dependent kinases inside host cells.

10 May 2022

miRNAs associated with varying clinical presentations of SARS-CoV-2

A recent article published in the journal iSCIENCE demonstrated different micro ribonucleic acids (miRNAs) linked with various presentations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

5 May 2022

Relevance of stem-loop 2 motif in SARS-CoV-2 and astroviruses

A recent paper posted to the bioRxiv* preprint server demonstrated that the stem-loop 2 motif (s2m) was substantial for astroviruses but unnecessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 May 2022

Study evaluates hybridization probe capture for enriching coronavirus genomic material in bat oral and rectal swabs

Researchers surveilled coronaviruses found in bats via targeted genomic sequencing.

29 Apr 2022

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Researchers utilized a CRISPR/Cas9 system to evaluate the usage of tRNA by deleting two tRNA genes from the genomes of hyper hepatocellular carcinoma and human near-haploid chronic myeloid leukemia cells.

27 Apr 2022

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

My work is focused on looking at the dynamics of B/T cell populations within lymph nodes from patients that had recovered from COVID-19. My role in this research was developing and implementing microscopy image analysis techniques using methods and instrumentation in part supplied by TissueGnostics.

From TissueGnostics 26 Apr 2022

Nucleotides News and Research

SARS-CoV-2 evolutionary trends provide insights into its adaptive process to human hosts

The role of pyroptosis in COVID-19

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Computational modeling fine tunes RBD-1C aptamer against SARS-CoV-2 S protein

Study explores the substrate selectivity of the SARS-CoV-2 replicase

Scientists discover how immune proteins defend plants against invading microorganisms

CDC study reveals hybrid SARS-CoV-2 spike from Delta/Omicron recombination event

Repeated DNA sequences in the genome may contribute to schizophrenia risk

The promise of RNA medicine is targeted and personalized

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

miRNAs associated with varying clinical presentations of SARS-CoV-2

Relevance of stem-loop 2 motif in SARS-CoV-2 and astroviruses

Study evaluates hybridization probe capture for enriching coronavirus genomic material in bat oral and rectal swabs

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

Study evaluates SARS-CoV-2 whole genome data from patients and staff in the VA Northeast Ohio Healthcare System

Exploring SARS-CoV-2 detection by profiling micro RNAs

“MixOmicron” SARS-CoV-2 recombinant evades variant screening

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

A summary of SARS-CoV-2 RNA-protein interactome studies

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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