Renin News and Research

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Renin, also known as angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin system (RAS) that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure.

Human recombinant soluble ACE2 successfully used in a patient with severe COVID-19

A multinational research group recently published a paper in the journal Lancet Respiratory Medicine which describes the first patient with a severe form of coronavirus disease (COVID-19) that was successfully treated with human recombinant soluble ACE2.

27 Sep 2020

AI used to define the cytokine storm implicated in fatal COVID-19

A new study published on the preprint server bioRxiv* in September 2020 reports the use of artificial intelligence (AI) to identify an invariant or universal host immune response found in all viral pandemics so far. The association of this response with severe COVID-19 phenotypes indicates a new understanding of the human immune response in viral pandemics.

24 Sep 2020

Key China COVID-19 study produced results that influenced subsequent research on coronavirus

Early in the onset of the COVID-19 pandemic, a small study in China produced results that influenced subsequent research on the virus.

18 Sep 2020

American Heart Association honors UVA professor for contributions to cardiovascular research

Robert M. Carey, MD, Professor of Medicine at the University of Virginia School of Medicine, has been named a Distinguished Scientist of the American Heart Association for his "extraordinary contributions" to cardiovascular research.

8 Sep 2020

Common heart drugs are safe for patients hospitalized with COVID-19

Heart patients hospitalized with COVID-19 can safely continue taking angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), according to the BRACE CORONA trial presented in a Hot Line session today at ESC Congress 2020.

1 Sep 2020

$Sacubitril/valsartan therapy may reduce hospitalization in heart patients with preserved ejection fraction$

Sacubitril/valsartan therapy may reduce hospitalization in heart patients with preserved ejection fraction

Sacubitril/valsartan reduces NT-proBNP, a biomarker predictive of long-term clinical outcomes in heart failure, but does not improve functional capacity compared to individualized background therapy in patients with heart failure with preserved ejection fraction

1 Sep 2020

Estradiol appears to help in female SARS-CoV-2 infection

A new study published on the preprint server medRxiv in August 2020 shows that the risk of infection is high for pre-menopausal women but the risk of death is much higher for men in the same age group and throws light on the protective nature of estradiol therapy in post-menopausal women.

26 Aug 2020

Inhaled steroids reduce SARS-CoV-2-related genes in COPD

A new study published on the preprint server medRxiv* aims to explore the effects of treatment with ICS on the expression of specific genes related to SARS-CoV-2 infection in bronchial epithelial cells in a prospective interventional design.

25 Aug 2020

Antihypertensives reduce severity of Covid-19 infection and death

Medication for high blood pressure could improve Covid-19 survival rates and reduce the severity of infection - according to new research from the University of East Anglia.

25 Aug 2020

Antihypertensives improve COVID-19 survival rates

Previous studies have also linked hypertension to severe coronavirus disease (COVID-19). Now, a new study by researchers at the University of East Anglia's Norwich Medical School has found that the risk of severe COVID-19 and death was reduced for patients with high blood pressure who were taking Angiotensin-Converting Enzyme inhibitors (ACEi) or Angiotensin Receptor Blockers (ARB).

24 Aug 2020

DHODH inhibitor PTC299 shows potential as a COVID-19 therapeutic

As COVID-19 continues to take a heavy toll on human health and life in many parts of the world, there is still no effective antiviral drug or vaccine. This has fueled an intensive search for small molecules and proteins that can inhibit viral entry and replication.

10 Aug 2020

Large-scale analysis of Alport syndrome reveals the effectiveness of existing treatments

A large-scale analysis of the clinical characteristics of Alport syndrome in Japanese patients has revealed that the effectiveness of existing treatment with ACE inhibitors and/or angiotensin receptor blockers (RAS inhibitors) varies depending on the type of mutation in the syndrome's causal gene (COL4A5).

7 Aug 2020

Renin News and Research

Further Reading

Human recombinant soluble ACE2 successfully used in a patient with severe COVID-19

AI used to define the cytokine storm implicated in fatal COVID-19

Key China COVID-19 study produced results that influenced subsequent research on coronavirus

American Heart Association honors UVA professor for contributions to cardiovascular research

Common heart drugs are safe for patients hospitalized with COVID-19

Sacubitril/valsartan therapy may reduce hospitalization in heart patients with preserved ejection fraction

Estradiol appears to help in female SARS-CoV-2 infection

Inhaled steroids reduce SARS-CoV-2-related genes in COPD

Antihypertensives reduce severity of Covid-19 infection and death

Antihypertensives improve COVID-19 survival rates

DHODH inhibitor PTC299 shows potential as a COVID-19 therapeutic

Large-scale analysis of Alport syndrome reveals the effectiveness of existing treatments

Novel short ACE2 isoform may influence SARS-CoV-2 susceptibility

Computational analyses suggest new pathway for inflammatory response to SARS-CoV-2

Mouse model of fatal COVID-19 developed for vaccine and drug testing

Novel blood test for heart failure could lead to new diagnostics for COVID-19 patients

UTHealth physicians investigate blood pressure drug's effect on improving COVID-19 outcomes

SARS-CoV-2 a dagger to the aging heart

COVID-19 complications may be associated with von Willebrand factor in the blood

Study shows generic drug does not slow kidney disease

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