Transcription Factors News and Research

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Researchers identify a bivalent histone-mark switch essential for angiogenesis

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells.

8 Feb 2022

Antibody drug improves survival rates in canine prostate cancer model

Dogs are proving to be a far better scientific model for study of prostate cancer than mice, the typical animal used in the lab for this type of research.

8 Feb 2022

Regulatory sequences in the genomes of mammals help explain how cancer invades normal tissues

Researchers from UConn Heath and Yale University have made new advances connecting the evolution of pregnancy and cancer metastasis.

8 Feb 2022

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Life starts with one cell. When an organism develops, dividing cells specialize to form the variety of tissues and organs that build up the adult body, while keeping the same genetic material – contained in our DNA.

6 Feb 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

In a new study, researchers discuss the role of calcium signaling pathways as targets of inhibition in potential new antiviral therapeutic pathways for SARS-CoV-2.

20 Jan 2022

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

In a new study, researchers used bioinformatics tools to explore the biological characteristics of SARS-CoV-2-infected myocardium.

19 Jan 2022

Modular super-enhancer regulates gene expression involved in retina development

Enhancers are regions of DNA that do not code for proteins, but control how genes are expressed. Super-enhancers are clusters of enhancers that together regulate genes with important roles in cell identity.

11 Jan 2022

Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events

Researchers deploy mutagenesis studies to investigate the relationship between ORF6 localization and IFN antagonism.

12 Dec 2021

Researchers identify mechanism behind regulation of large exon splicing during vertebrate evolution

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the mechanism behind regulated splicing of large constitutive exons which are rich in disordered regions, and their potential involvement in the assembly of transcription factors.

21 Nov 2021

Study reveals mechanism by which vitamin D reduces inflammation caused by immune cells

Scientists recently gained insights into how vitamin D functions to reduce inflammation caused by immune cells that might be relevant to the responses during severe COVID-19. In a study jointly published by Purdue University and the National Institutes of Health, scientists do just that.

18 Nov 2021

How long does natural or vaccine-induced immunity to COVID last?

Researchers present a comprehensive assessment on SARS-CoV-2 induced immunity.

28 Oct 2021

New insight into the tremendously complex "genetic dance"

The rapid scientific advancements that followed the mapping of the human genome have revealed just how staggeringly complex the world of genetics is.

28 Oct 2021

Researchers find how iron deficient plants protect themselves from damaging light

Researchers have identified how iron deficient plants protect themselves from damaging light, according to a Dartmouth study.

13 Oct 2021

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

In this review, researchers summarized the therapeutic and pathogenic role of IL-7 in patients with COVID-19 and examined the promising role of IL-7 as a vaccine adjuvant.

7 Oct 2021

Three U of U Health researchers win the 2021 NIH Director’s New Innovator Award

The National Institutes of Health has awarded grants to three University of Utah Health scientists through its competitive High-Risk, High-Reward Research (HRHR) program that funds highly innovative and unusually impactful biomedical or behavioral research proposed by extraordinarily creative scientists.

5 Oct 2021

Machine learning pinpoints genes that enable plants to grow more with less fertilizer

Machine learning can pinpoint "genes of importance" that help crops to grow with less fertilizer, according to a new study published in Nature Communications. It can also predict additional traits in plants and disease outcomes in animals, illustrating its applications beyond agriculture.

25 Sep 2021

Study provides novel insights into how KLF4 influences gene expression

A team led by researchers at Baylor College of Medicine has discovered a mechanism by which transcription factor KLF4 can help to organize chromatin, thus influencing gene expression.

23 Sep 2021

Scientists use statistical mechanics to make sense of DNA folding

At more than 2 meters long, the human DNA molecule uses intricate folding patterns to fit into cells while locally unfolding to express genes. Such phenomena, however, are difficult to measure in experiments, and theoretical frameworks explaining them continue to be at odds with one another.

22 Sep 2021

SARS-CoV-2 NSP1 protein suppresses host genes while enhancing viral RNA expression

In a recent study, researchers study the molecular aspects of SARS-CoV-2 host cell entry and inhibition of host-specific cellular mechanisms.

20 Sep 2021

Transcription Factors News and Research

Researchers identify a bivalent histone-mark switch essential for angiogenesis

Antibody drug improves survival rates in canine prostate cancer model

Regulatory sequences in the genomes of mammals help explain how cancer invades normal tissues

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

Modular super-enhancer regulates gene expression involved in retina development

Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events

Researchers identify mechanism behind regulation of large exon splicing during vertebrate evolution

Study reveals mechanism by which vitamin D reduces inflammation caused by immune cells

How long does natural or vaccine-induced immunity to COVID last?

New insight into the tremendously complex "genetic dance"

Researchers find how iron deficient plants protect themselves from damaging light

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

Three U of U Health researchers win the 2021 NIH Director’s New Innovator Award

Machine learning pinpoints genes that enable plants to grow more with less fertilizer

Study provides novel insights into how KLF4 influences gene expression

Scientists use statistical mechanics to make sense of DNA folding

SARS-CoV-2 NSP1 protein suppresses host genes while enhancing viral RNA expression

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