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Researchers find gene that shapes mutation rate in mice

Every organism is born with a few mutations in their genome that differ genetically from both of their parents.

11 May 2022

Hypermutation in children could be linked to the biological father receiving chemotherapy treatments

Some rare cases of higher genetic mutation rates in children, known as hypermutation, could be linked to the father receiving certain chemotherapy treatments, new research has found.

11 May 2022

New initiative focuses on patients with the rarest of gene mutations to develop personalized ALS therapies

A new initiative, Silence ALS, will develop experimental personalized therapies to treat patients with rare genetic forms of ALS (also known as Lou Gehrig's disease).

10 May 2022

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

An article published in the journal Molecular Psychiatry reveals the molecular mechanisms to explain how the YWHAZ gene –related to psychiatric and neurological disorders such as autism and schizophrenia– can alter the neurodevelopmental process.

10 May 2022

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

UNC School of Medicine Scientists have shown for the first time that postnatal gene therapy may be able to prevent or reverse many deleterious effects of a rare genetic disorder called Pitt-Hopkins syndrome.

10 May 2022

Study uncovers new regulator of prostate cancer metastasis

A transcription factor normally associated with androgen receptor activity in prostate cancer has a newly discovered role in controlling lipid biosynthesis, according to a Northwestern Medicine study published in Nature Genetics.

10 May 2022

Heightened antibody responses in COVID-19 booster vaccinated individuals following SARS-CoV-2 Omicron

Investigators illustrated that a SARS-CoV-2 Omicron infection post-booster vaccination imparts robust, long-lasting immunity against future re-infections.

10 May 2022

bit.bio launches Huntington’s disease human cell model

First neurodegenerative disease model launched from bit.bio's new ioDisease Model portfolio.

From bit.bio 10 May 2022

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children.

9 May 2022

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

In this interview, we speak to Steffi Oesterreich, PH.D., from the University of Pittsburgh, about how new insights into a gene mutation present in 20-30% of breast cancer recurrences may have a silver lining, leading to novel treatment opportunities.

9 May 2022

New tool can help researchers interpret the clinical significance of somatic mutations in cancer

Researchers at Children's Hospital of Philadelphia have developed a new tool to help researchers interpret the clinical significance of somatic mutations in cancer.

6 May 2022

Applying a form of AI to sift through large amounts of biological data

Researchers at the University of Missouri are applying a form of artificial intelligence (AI) - previously used to analyze how National Basketball Association (NBA) players move their bodies - to now help scientists develop new drug therapies for medical treatments targeting cancers and other diseases.

6 May 2022

Mutation News and Research

Researchers find gene that shapes mutation rate in mice

Hypermutation in children could be linked to the biological father receiving chemotherapy treatments

New initiative focuses on patients with the rarest of gene mutations to develop personalized ALS therapies

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

Study uncovers new regulator of prostate cancer metastasis

Heightened antibody responses in COVID-19 booster vaccinated individuals following SARS-CoV-2 Omicron

bit.bio launches Huntington’s disease human cell model

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

New tool can help researchers interpret the clinical significance of somatic mutations in cancer

Applying a form of AI to sift through large amounts of biological data

SARS-CoV-2 variants are not evolving to escape from T cell-mediated immunity

New method improves polygenic prediction of disease risk across diverse populations

Study identifies two new Omicron lineages associated with a resurgence in infections in South Africa

Relevance of stem-loop 2 motif in SARS-CoV-2 and astroviruses

SARS-CoV-2 Omicron BA.2.12.1, BA.4 and BA.5 subvariants are superior to their predecessors

Benefits of endurance exercise in primary mitochondrial disease depend on the underlying mutation

New Machine Learning model draws a map of proteins with special properties

The sensitivity of Omicron subvariants to therapeutic monoclonal antibodies

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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