Preclinical News and Research

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Does wholegrain consumption impact measures of cognitive decline, mood, and anxiety?

Researchers investigated the association between the consumption of whole grains and cognitive decline measures.

21 Apr 2023

Study links astrocytic TDP-43 dysfunction to cognitive decline in dementia: Unlocking potential therapeutic strategies

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20 Apr 2023

Preclinical study reveals a potential new therapeutic approach to treating common lung cancer

Researchers at the Icahn School of Medicine at Mount Sinai have demonstrated in a preclinical study a potential new therapeutic approach to treating the most common form of lung cancer.

20 Apr 2023

Using engineered stem cells to treat ALS and retinitis pigmentosa

Cedars-Sinai investigators are developing a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments.

20 Apr 2023

Study uncovers a protein-protein interaction that contributes to Parkinson's disease

In a study published in Nature Communications, a team led by Krembil Brain Institute Senior Scientists, Drs. Lorraine Kalia and Suneil Kalia, and University of Toronto (U of T) Professor, Dr. Philip M. Kim, identified a protein-protein interaction that contributes to Parkinson's disease.

20 Apr 2023

Assessing the efficacy, safety and tolerability of AXA1125 in long COVID patients

Researchers evaluated the effectiveness of endogenous metabolic modulator, AXA1125.

19 Apr 2023

Cocktail of IgG3 antibodies could have a potent clinical effect against SARS-CoV-2

Is it possible to improve the antibodies that the body produces to fight SARS-CoV2? In a study led by researchers from Lund University in Sweden, this was investigated by redesigning antibodies and combining them against the virus.

18 Apr 2023

The importance and challenges of developing mucosal SARS-COV-2 vaccines

In November 2022, the National Institute of Allergy and Infectious Diseases co-hosted a virtual workshop on the importance and challenges of developing mucosal vaccines for SARS-COV-2.

13 Apr 2023

New approach identifies significant molecular changes linked to pediatric bipolar disorder

It's extremely difficult to study the biological basis of psychiatric disorders, in part because researchers can't easily collect brain cells from living people to study in the laboratory. Now, University of Utah Health scientists have developed a way around that.

12 Apr 2023

Radioimmunotherapy cures human non-Hodgkin lymphoma in animal model

A new nuclear medicine therapy can cure human non-Hodgkin lymphoma in an animal model, according to research published in the April issue of The Journal of Nuclear Medicine.

11 Apr 2023

Mint flavor in vaping liquids associated with worse lung function in e-cigarette users

Adding mint flavor to e-cigarette liquids produces more vapor particles and is associated with worse lung function in those who smoke, report researchers from the University of Pittsburgh in Respiratory Research today.

11 Apr 2023

Modified Botox can alleviate chronic pain without risk of paralysis or addiction

A modified form of Botox could give long-term pain relief to patients with chronic nerve injury pain, according to a new study.

11 Apr 2023

Lack of therapeutic markers leads to poorer outcomes in triple negative breast cancer

A new review paper was published in Oncotarget's Volume 14 on March 31, 2023, entitled, "Crosstalk between triple negative breast cancer and microenvironment."

10 Apr 2023

Novel amino acid compound treats nonalcoholic fatty liver disease in non-human primates

A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates - bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests.

10 Apr 2023

Study highlights the potential long-term neurological effects post-COVID-19

Researchers studied the presence of the SARS-CoV-2 spike protein in the skull-meninges-brain (SMB) axis.

10 Apr 2023

Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

Researchers highlight how dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment.

10 Apr 2023

Preclinical News and Research

Does wholegrain consumption impact measures of cognitive decline, mood, and anxiety?

Study links astrocytic TDP-43 dysfunction to cognitive decline in dementia: Unlocking potential therapeutic strategies

Preclinical study reveals a potential new therapeutic approach to treating common lung cancer

Using engineered stem cells to treat ALS and retinitis pigmentosa

Study uncovers a protein-protein interaction that contributes to Parkinson's disease

Assessing the efficacy, safety and tolerability of AXA1125 in long COVID patients

Cocktail of IgG3 antibodies could have a potent clinical effect against SARS-CoV-2

The importance and challenges of developing mucosal SARS-COV-2 vaccines

New approach identifies significant molecular changes linked to pediatric bipolar disorder

Radioimmunotherapy cures human non-Hodgkin lymphoma in animal model

Mint flavor in vaping liquids associated with worse lung function in e-cigarette users

Modified Botox can alleviate chronic pain without risk of paralysis or addiction

Lack of therapeutic markers leads to poorer outcomes in triple negative breast cancer

Novel amino acid compound treats nonalcoholic fatty liver disease in non-human primates

Study highlights the potential long-term neurological effects post-COVID-19

Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

Is there an association between body mass index and cognitive function in older adults?

Nasal SARS-CoV-2 vaccine outperforms existing vaccines in preclinical trial

How nanomedicine is revolutionizing care for cardiovascular disease

IU study sheds new light on the development and treatment of rare form of muscular dystrophy

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