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Race is associated with unfavorable breast cancer tumor biology

African-American women with breast cancer were more likely to have larger, later-stage tumors that were more difficult to treat and also had lower survival rates than Hispanic and Caucasian women who received the same treatment in two independent series of clinical trials examined by researchers from The University of Texas M. D. Anderson Cancer Center.

23 Oct 2006

Multivalent effects of RGD peptides obtained by nanoparticle display

While a growing body of literature has shown that nanoparticle targeting can improve drug delivery and tumor imaging, there have been few systematic studies examining the net positive effect of nanoparticle targeting.

23 Oct 2006

Squalenoyl nanomedicines as potential therapeutics

Nucleoside analogs such as cytarabine and gemcitabine are powerful anticancer agents, but a simple chemical modification that causes them to assemble into stable nanoparticles could make them even more valuable in the treatment of a wide variety of cancers.

23 Oct 2006

Functionalization of individual ultra-short single-walled carbon nanotubes

While most research aimed at developing carbon nanotubes as tumor-targeting drug and imaging agent delivery vehicles has focused on full-length nanotubes, Lon Wilson, Ph.D., and his colleagues at Rice University have been working with ultra-short nanotubes that cells appear to take up more efficiently than their longer counterparts.

23 Oct 2006

Genomic test decides which drug is best for cancers

Scientists at Duke University, North Carolina have developed a panel of tests which are able to analyze a cancerous tumor and then decide which chemotherapy will most efficiently attack the cancer.

23 Oct 2006

Targeted tumor therapy has paramount consequences for future expansion of nuclear medicine

Targeted tumor therapy lobs toxic payloads directly into tumors to destroy cancer cells while leaving normal cells unharmed.

20 Oct 2006

New treatment option gives hope to victims of head and neck cancers

More than 640,000 people worldwide are diagnosed with head and neck cancer each year, and more than 350,000 die from the disease annually.

19 Oct 2006

Elderly breast cancer patients often are underdiagnosed, undertreated

Elderly women often receive substandard breast cancer screenings and treatment and delayed diagnoses compared with younger patients, according to a study published in the October issue of the Journal of the American Medical Association's Archives of Surgery, the Wall Street Journal reports.

17 Oct 2006

New technique allows partial-match cell transplants for children with most resistant leukemia

Clinicians at St. Jude Children's Research Hospital have successfully demonstrated an improved technique for blood stem cell transplantations in children that shows promise for those most likely to fail standard treatment for leukemia.

16 Oct 2006

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

Efforts to treat cancer using genes and other oligonucleotides, such as short interfering RNA (siRNA), that turn off the biochemical processes that trigger malignancies have been hindered by difficulties in delivering nucleic acids to tumors.

16 Oct 2006

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

One of the unusual properties of tumor cells is that their cell membranes are more fluid and less rigid than those of normal cells.

16 Oct 2006

New York Times examines efforts to obtain FDA approval for Abraxane to treat earlier-stage cancer

The New York Times has examined efforts by the pharmaceutical company Abraxis BioScience to obtain FDA approval for its late-stage breast cancer drug Abraxane as a treatment for earlier-stage breast cancer.

5 Oct 2006

Super chow, laced with semi-synthetic vitamin E derivative, inhibited spread of cancer in mice

A chemically altered form of vitamin E mixed into mouse chow dramatically reduced spread of aggressive mammary cancer in mice, suggesting that the compound in pill form could be used to treat human metastatic cancer, according to a report in the October 1 issue of the journal Cancer Research.

2 Oct 2006

Temperature-sensitive nanoparticle boosts drug antitumor activity

Using temperature-sensitive, lipid- and polymer-based nanoparticles with a polymer coating, researchers in Korea have created an anticancer drug delivery vehicle that may provide a significant boost to the therapeutic efficacy of anticancer agents, particularly when used in conjunction with hyperthermia.

2 Oct 2006

Smart nanoscale bioreactors for drug delivery

In a powerful demonstration of how to build a multifunctional, smart nanoscale drug delivery system, researchers at the University of Basel have created a drug-loaded nanocontainer that targets specific cells and releases its payload when receiving a specific physiological signal.

2 Oct 2006