Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Research findings may offer a new potential therapeutic target for Alzheimer’s disease

A new study links a gene concentrated in the brain's cleanup cells, known as microglia, to the inflammation that has increasingly emerged as a key mechanism contributing to Alzheimer's disease.

30 Nov 2022

Study identifies a urinary biomarker to reveal early-stage Alzheimer’s disease

Could a simple urine test reveal if someone has early-stage Alzheimer’s disease and could this pave the way for large-scale screening programs? A new study in Frontiers in Aging Neuroscience certainly suggests so. The researchers tested a large group of patients with Alzheimer’s disease of different levels of severity and healthy controls with normal cognition to identify differences in urinary biomarkers.

30 Nov 2022

Study links MAIT cells to cognitive function

Could the underproduction of poorly understood immune cells contribute to Alzheimer's disease and other forms of cognitive decline? A Rutgers study in Nature Immunology suggests it may – and that increasing these cells could reverse the damage.

29 Nov 2022

Activation of microglial cells can slow down Alzheimer's progression

The brain's big-eating immune cells can slow down the progression of Alzheimer's disease. This is shown by a study that is now published in Nature Aging.

29 Nov 2022

Study reveals a promising therapeutic target for Alzheimer's disease

In a recent search for gene variants associated with Alzheimer's disease (AD), several affected families showed a mutation in an enzyme called protein kinase C-alpha (PKCα). Family members with this mutation had AD; those without the mutation did not.

28 Nov 2022

Machine learning pinpoints the most accurate timelines for predicting Alzheimer's progression

A Cornell-led collaboration used machine learning to pinpoint the most accurate means, and timelines, for anticipating the advancement of Alzheimer's disease in people who are either cognitively normal or experiencing mild cognitive impairment.

28 Nov 2022

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Researchers evaluated neuro-pathophysiological consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, especially the post-acute sequelae of SARS-CoV-2 (PASC) in Alzheimer’s disease (AD) patients.

28 Nov 2022

Klotho protein levels protect against cognitive decline in Alzheimer patients

Researchers compare Klotho protein levels of healthy individuals and patients diagnosed with different stages of Alzheimer’s disease.

27 Nov 2022

New biomarker can help identify people with a primary tauopathy

Zooming in on a single disease and studying it intensely is often the most productive route to finding treatments. But there's no easy way to distinguish among people living with any of the primary tauopathies - a group of rare brain diseases marked by rapidly worsening problems with thinking and movement - because the symptoms are too similar.

24 Nov 2022

Two new studies identify potential risk factors associated with frontotemporal dementia

Two recent studies from the University of Eastern Finland show that educational background and previous traumatic brain injury may potentially affect the risk of frontotemporal dementia.

24 Nov 2022

Study can provide deeper insight into the link between common oral bacteria and other diseases

Researchers at Karolinska Institutet in Sweden have identified the bacteria most commonly found in severe oral infections. Few such studies have been done before, and the team now hopes that the study can provide deeper insight into the association between oral bacteria and other diseases. The study is published in Microbiology Spectrum.

24 Nov 2022

Time-restricted eating may benefit Alzheimer's

In a recent study published in the Experimental Gerontology journal, researchers in the United States assessed the impact of time-restricted eating (TRE) on Alzheimer's disease (AD), cognitive decline, and sleep.

21 Nov 2022

Researchers to develop brain imaging radiotracers for better understanding of Alzheimer's, autism

Emory researchers are on the cusp of seeing in real time how brain diseases like Alzheimer's and autism spectrum disorder affect a patient's brain function.

21 Nov 2022

UCF researcher examines the mechanisms of COVID-19 pathogenesis in patients with diabetes

Can a COVID-19 infection have long-term health effects on people with diabetes, including advancing their risk for heart disease?

20 Nov 2022

Type 2 diabetes patients older than 45 have increased MS risk after anti-hyperglycemic exposure

A new University of Arizona Health Sciences study found that people older than 45 whose Type 2 diabetes was treated with anti-hyperglycemic medications had an increased risk of multiple sclerosis, particularly among women, while anti-hyperglycemic exposure in people younger than 45 reduced that risk.

20 Nov 2022

Gut microbiome plays a role in Alzheimer's

In a recent review published in the journal Pharmacological Research, researchers in Brazil investigated the role of gut microbiota in cognition, brain function, behavior, and neurodegenerative disease pathogenesis.

17 Nov 2022

Research highlights an understudied aspect of Alzheimer’s disease

Memory loss is often the first sign of Alzheimer's disease, followed by confusion and difficulty thinking. These symptoms reflect the typical pattern of worsening damage to brain tissues. Toxic clusters of proteins first concentrate in the temporal lobes of the brain - the memory area - before spreading to parts of the brain important for thinking and planning.

17 Nov 2022

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

A gene recognized as the strongest risk factor for Alzheimer's disease (AD) alters the way cholesterol moves around the brain and as we age, this altered movement likely contributes to loss of learning and memory, a team of researchers from the Icahn School of Medicine at Mount Sinai and the Massachusetts Institute of Technology reports.

16 Nov 2022

Amyloid-PET scanning has misled the FDA into granting approval for Aduhelm

Last year, the FDA gave accelerated approval of the antibody aducanumab (marketed as Aduhelm by Biogen) for the treatment of Alzheimer's disease.

16 Nov 2022

Can a multicultural healthy diet reduce cognitive decline and Alzheimer's disease risk?

Scientists conducted a pilot randomized controlled clinical trial to investigate whether a multicultural healthy diet can reduce cognitive decline and Alzheimer’s disease risk in adults aged 40 – 65.

16 Nov 2022

Alzheimer's Disease News and Research

Further Reading

Research findings may offer a new potential therapeutic target for Alzheimer’s disease

Study identifies a urinary biomarker to reveal early-stage Alzheimer’s disease

Study links MAIT cells to cognitive function

Activation of microglial cells can slow down Alzheimer's progression

Study reveals a promising therapeutic target for Alzheimer's disease

Machine learning pinpoints the most accurate timelines for predicting Alzheimer's progression

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Klotho protein levels protect against cognitive decline in Alzheimer patients

New biomarker can help identify people with a primary tauopathy

Two new studies identify potential risk factors associated with frontotemporal dementia

Study can provide deeper insight into the link between common oral bacteria and other diseases

Time-restricted eating may benefit Alzheimer's

Researchers to develop brain imaging radiotracers for better understanding of Alzheimer's, autism

UCF researcher examines the mechanisms of COVID-19 pathogenesis in patients with diabetes

Type 2 diabetes patients older than 45 have increased MS risk after anti-hyperglycemic exposure

Gut microbiome plays a role in Alzheimer's

Research highlights an understudied aspect of Alzheimer’s disease

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

Amyloid-PET scanning has misled the FDA into granting approval for Aduhelm

Can a multicultural healthy diet reduce cognitive decline and Alzheimer's disease risk?

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