Immune System News and Research

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Study cracks the cold case of immunotherapy resistance

A study from the University of Michigan Health Rogel Cancer Center may have, at last, cracked the cold case of immunotherapy resistance.

3 Dec 2024

New immune therapy improves survival and reduces tumor burden in glioblastoma

The Wistar Institute's David B. Weiner, Ph.D. - Executive Vice President, director of the Vaccine & Immunotherapy Center and W.W. Smith Charitable Trust Distinguished Professor in Cancer Research - and his lab have successfully tested a new immune therapy that, in preclinical lab testing, reliably improves survival and reduces tumor burden in glioblastoma.

3 Dec 2024

Study finds T cell exhaustion in chronic fatigue syndrome patients

Chronic fatigue syndrome creates conditions where pathogen-killing immune T cells become exhausted, according to a new Cornell University study.

3 Dec 2024

Inflammation and organ damage in severe COVID-19 tied to mitochondrial dysfunction

Severe COVID-19 arises in part from the SARS-CoV-2 virus's impact on mitochondria, tiny oxygen-burning power plants in cells, which can help trigger a cascade of organ- and immune system-damaging events, suggests a study by investigators at Weill Cornell Medicine, Johns Hopkins Medicine, Children's Hospital of Philadelphia, and the University of Pittsburgh School of Medicine, along with other members of the COVID-19 International Research Team.

3 Dec 2024

Pregnancy strengthens immune defense against flu, study finds

McGill University scientists have discovered that pregnancy may trigger a natural immunity to boost protection against severe flu infection.

2 Dec 2024

CU Anschutz Medical Campus receives $46 million for blindness cure research

The University of Colorado Anschutz Medical Campus will receive up to $46 million from the Advanced Research Projects Agency for Health (ARPA-H) Transplantation of Human Eye Allografts (THEA) program to advance pioneering research aimed at curing total blindness through human eye transplantation.

2 Dec 2024

Study reveals pathways behind organ damage in severe COVID-19

New research published in the journal Proceedings of the National Academy of Sciences sheds light on the pathways that drive organ damage and death in severe COVID-19 and helps explain why survivors of the disease can experience long-term complications.

2 Dec 2024

New study explores heart risks of cancer immunotherapy

A cancer therapy that prompts the body's immune defenses against viruses and bacteria to attack tumors can make patients more vulnerable to heart attack and stroke.

2 Dec 2024

Natural proteins may offer new way to treat covid-19 and autoimmune disorders

Some people naturally have higher levels of proteins that protect them from covid-19. New studies at Umeå University of our immune system may pave the way for more personalized treatments of both covid-19 and autoimmune disorders.

2 Dec 2024

Fibroblastic reticular cells power immune defenses in lung cancer

Fibroblastic reticular cells (FRCs) create T-cell-supportive niches within lung cancer tumors, facilitating T-cell migration, clustering, and activation. This study highlights FRCs' potential as therapeutic targets to boost anti-tumor immunity in non-small cell lung cancer (NSCLC).

1 Dec 2024

Warmer temperatures weaken immune systems in wild capuchin monkeys

The immune performance of wild capuchin monkeys declines when the animals experience higher temperatures, and younger monkeys seem to be particularly vulnerable to heat, according to a University of Michigan study.

29 Nov 2024

STAG2 loss linked to increased aggression in Ewing sarcoma

Ewing sarcoma is a tumor of the bones and soft tissues that occurs in children and young people. Like all childhood cancers, it is rare – 9 to 10 cases per million inhabitants per year – but it is very aggressive. 25% of patients do not respond well to regular therapy and they often experience relapses.

29 Nov 2024

Fungus found in the mouse stomach may hold a key to fungal evolution in the gut

A fungus discovered in the mouse stomach may hold a key to fungal evolution within the gastrointestinal tract, according to new research led by Weill Cornell Medicine investigators.

27 Nov 2024

Exploring sleep's role in blood pressure regulation across genders

You may have heard sleep described as something of a magic pill for the body. With the right amount, timing, and quality, it can work wonders - strengthen the immune system, improve blood sugar, even decrease the risk of heart attacks and strokes.

27 Nov 2024

Study links cell death pathway to cancer resistance and growth

A new study has uncovered an unexpected way cancer cells can escape the immune system, making it harder for treatments to work. The study, published in Cancer Cell, explains how a type of cancer cell death can actually make tumors grow faster by turning off the immune system's ability to fight the cancer.

27 Nov 2024

MR1 molecule and vitamin B6 could unlock new paths for cancer immunotherapy

Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1.

27 Nov 2024

PD-1 deficiency reveals the impact of checkpoint inhibition on B cell function

A multinational collaboration co-led by the Garvan Institute of Medical Research has uncovered a potential explanation for why some cancer patients receiving a type of immunotherapy called checkpoint inhibitors experience increased susceptibility to common infections.

27 Nov 2024