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Scientists develop new drug delivery system for treating genetic diseases

A team of researchers led by Harvard and Broad Institute scientists has developed a new drug delivery system using engineered DNA-free virus-like particles (eVLPs) to package and deliver therapeutic levels of gene-editing proteins to animal models of disease.

22 Jan 2022

Study shows monoclonal antibody and antiviral therapy are useful in preventing the severity of SARS-CoV-2 Omicron infection

In a new study, researchers assessed the efficacy of the FDA-approved therapeutic mAbs, as well as to small-molecule antiviral agents against the SARS-CoV-2 Omicron variant in Syrian hamsters.

21 Jan 2022

Scientists identify a new switch for controlling motor proteins

Inside neurons, motor proteins haul precious cargo, moving essential goods along thread-like roadways called microtubule tracks.

21 Jan 2022

Study suggests SARS-CoV-2 Omicron variant spike mediated immune escape and tropism shift

A new study showed that the SARS-CoV-2 Omicron spike binds to its receptor with enhanced affinity and yet evades vaccine-elicited neutralizing antibodies and that a booster mRNA vaccine broadened the neutralization of Omicron.

21 Jan 2022

Traumatic brain injury can lead to long-term visual impairment, finds study

Even mild head injuries can mean serious consequences for brain function at its most basic level. Research published in Communications Biology shows that neuroplasticity, too, has its limits.

21 Jan 2022

The tetrapeptide tuftsin effectively impairs the binding of SARS-CoV-2 S1 to ACE2

In their recent study posted to the preprint server bioRxiv*, the researchers from China have shown that tuftsin, a natural phagocytosis-stimulating peptide, can effectively impair the binding of SARS-CoV-2 spike S1 subunit to ACE2 receptor in a dose-dependent manner and therefore can be considered a potential drug against SARS-CoV-2 infection.

20 Jan 2022

Exploring the interactions between multiple respiratory viruses

A recent report explores the dynamics of viral interference between various respiratory viruses in light of the ongoing COVID-19 pandemic.

19 Jan 2022

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

In a new study, researchers used bioinformatics tools to explore the biological characteristics of SARS-CoV-2-infected myocardium.

19 Jan 2022

Chinese scientists reveal key role of lysosome cell death regulator in lung tumor survival

Chinese scientists recently reported the key role of histone acetylation-regulated long noncoding RNA termed as lysosome cell death regulator (LCDR) in tumor survival, providing a potential diagnostic and therapeutic target for lung cancer.

18 Jan 2022

Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

New research assesses the NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in response to SARS-CoV-2 and its spike protein, and the effects of this exposure in the presence of a-synuclein protein aggregate fibrils.

17 Jan 2022

Researchers engineer enucleated cells to deliver therapeutics precisely to diseased tissues

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health report successfully removing the nucleus out of a type of ubiquitous cell, known as enucleation, then using the genetically engineered cell as a unique cargo-carrier to deliver therapeutics precisely to diseased tissues.

17 Jan 2022

Monitoring rodents for SARS-CoV-2 and other coronaviruses, Hong Kong

A new study published in the Centers for Disease Control and Prevention’s Emerging Infectious Diseases journal has hypothesized that locations with positive SARS-CoV-2 in sewage could be used as potential surveillance targets to analyze if pestiferous urban rodents shed SARS-CoV-2 into the environment.

16 Jan 2022

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

A new study, published in the journal Cell Chemical Biology, has reported the discovery of acriflavine (ACF), an effective inhibitor of SARS-CoV-2. This drug is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine).

16 Jan 2022

in vivo News and Research

Scientists develop new drug delivery system for treating genetic diseases

Study shows monoclonal antibody and antiviral therapy are useful in preventing the severity of SARS-CoV-2 Omicron infection

Scientists identify a new switch for controlling motor proteins

Study suggests SARS-CoV-2 Omicron variant spike mediated immune escape and tropism shift

Traumatic brain injury can lead to long-term visual impairment, finds study

The tetrapeptide tuftsin effectively impairs the binding of SARS-CoV-2 S1 to ACE2

Exploring the interactions between multiple respiratory viruses

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

Chinese scientists reveal key role of lysosome cell death regulator in lung tumor survival

Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

Researchers engineer enucleated cells to deliver therapeutics precisely to diseased tissues

Monitoring rodents for SARS-CoV-2 and other coronaviruses, Hong Kong

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

Virus-like particles as delivery vehicles for gene-editing

Investigating the presence of human rRNA in the SARS-CoV-2 genome

Using lab-grown stomachs to shed light on the symptoms of COVID-19

Wearable sweat sensors can help assess an individual's health

Engineering higher affinity SARS-CoV-2 antibodies

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

Withdrawing steroid treatment found to boost SARS-CoV-2 vaccine-induced immunity in kidney transplant recipients

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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