Clinical Trial News and Research

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Guidelines for reporting health research have little funding

Although reporting guidelines can improve the accuracy and reliability of research reports, there is little funding available for developing such guidelines, according to a new survey published in the open access journal PLoS Medicine this week.

24 Jun 2008

Seven biomarkers that may help pinpoint prostate cancer recurrence found

A simple blood test may help doctors better predict whether prostate cancer will recur or spread in patients who have undergone surgery for the disease, UT Southwestern Medical Center researchers have found.

24 Jun 2008

Drug rapamycin reverses mental retardation caused by tuberous sclerosis complex

UCLA researchers discovered that an FDA-approved drug reverses the brain dysfunction inflicted by a genetic disease called tuberous sclerosis complex (TSC). Because half of TSC patients also suffer from autism, the findings offer new hope for addressing learning disorders due to autism. Nature Medicine publishes the findings in its online June 22 edition.

23 Jun 2008

Could Gleevec help stroke victims?

For over a decade, the drug called tPA has proven its worth as the most effective emergency treatment for the most common kind of stroke. But its promise is blemished by two facts: tPA can cause dangerous bleeding in the brain, and its brain-saving power fades fast after the third hour of a stroke.

23 Jun 2008

Patient's own infection-fighting T cells put late-stage melanoma into long-term remission

Researchers describe the first successful use of a human patient's cloned infection-fighting T cells as the sole therapy to put an advanced solid-tumor cancer into long-term remission. A team led by Cassian Yee, M.D., an associate member of the Clinical Research Division at Fred Hutchinson Cancer Research Center, reports these findings in the June 19 issue of the New England Journal of Medicine.

19 Jun 2008

New findings show obesity-related complications improve six months following gastric banding procedure

Teenagers' obesity-related medical complications improve just six months after laparoscopic gastric banding surgery, according to outcomes data presented this week.

19 Jun 2008

Seven biomarkers found that predict with 86 percent accuracy prostate cancer recurrence

A simple blood test may help doctors better predict whether prostate cancer will recur or spread in patients who have undergone surgery for the disease, researchers at UT Southwestern Medical Center have found.

17 Jun 2008

University of California, San Francisco embraces web 2.0 for health information

YouTube and The University of California, San Francisco (UCSF) today launched a comprehensive Internet video channel dedicated to the improved understanding of incurable neurodegenerative brain diseases.

16 Jun 2008

Scaling and root planing dental treatment safe for pregnant women

Pregnant women can safely undergo essential dental treatment and receive topical and local anesthetics at 13 to 21 weeks gestation, says a study published in the June issue of The Journal of the American Dental Association.

11 Jun 2008

Maxygen receives approval for trial of factor VIIa in UK

Maxygen, Inc. today announced that it has filed a Clinical Trial Authorization (CTA) and received the necessary approvals in the United Kingdom to initiate a first-in-human Phase I trial of MAXY-VII in hemophilia patients.

11 Jun 2008

Local doctors trial the coil to prevent womb cancer

New research in Yorkhill Hospital and Glasgow Royal Infirmary is investigating whether a form of the contraceptive coil can stop women from developing womb cancer.

11 Jun 2008

Heart Failure 2008 - Congress to address a heart condition whose prevalence is increasing with 'exponential growth'

Heart failure is by far the single biggest reason for acute hospital admission. Around 30 million people in Europe have heart failure and its incidence is still increasing: more cases are being identified, more people are living to an old age, and more are surviving a heart attack but with damage to the heart muscle.

11 Jun 2008

St. John's wort not effective for treating ADHD

Children and teens with attention-deficit/hyperactivity disorder (ADHD) who were treated with the herb St. John's wort did not have any greater improvement in ADHD symptoms compared to those who received placebo, according to a study in the June 11 issue of JAMA, the Journal of the American Medical Association.

11 Jun 2008

New grant to enable University of Rochester to increase HIV research by 25 percent

The University of Rochester today announced that the National Institutes of Health (NIH) has awarded a team of more than 50 researchers a five-year, $3.2 million grant.

4 Jun 2008

U of M sets new standard of care for recessive dystrophic epidermolysis bullosa

Physicians at the University of Minnesota and University of Minnesota Children's Hospital, Fairview have set the path to a cure for a young boy's fatal genetic skin disease, recessive dystrophic epidermolysis bullosa (RDEB), by using a cord blood and bone marrow transplant. Nate Liao, a 25-month-old from Clarksburg, N.J., underwent the experimental therapy in October 2007.

3 Jun 2008

ThromboGenics and BioInvent report positive results for anti-PlGF cancer therapeutic TB-403

ThromboGenics NV and co-development partner BioInvent International AB today reported that the results from the first Phase l study of novel anti-cancer agent TB-403 showed that it is safe and well tolerated, with pharmacokinetic properties enabling it to be developed for the treatment of cancer

3 Jun 2008

Study looks at the role of metformin as possible anti-tumor agent

Metformin, the common first-line drug for type 2 diabetes, may be effective in increasing pathologic complete response rates in diabetic women with early stage breast cancer who took the drug during chemotherapy prior to having surgery, paving the way for further research of the drug as a potential cancer therapy, according to researchers at The University of Texas M. D. Anderson Cancer Center.

2 Jun 2008

New breast cancer drug combo shrinks aggressive tumours

An international trial of a new breast cancer drug has shown the drug is able to shrink tumours caused by one of the most aggressive forms of the disease.

2 Jun 2008

Peregrine Pharmaceuticals updates on Bavituximab breast cancer study

Peregrine Pharmaceuticals, Inc. has announced that results from a Phase I clinical trial of its lead anti-phosphatidylserine (anti-PS) antibody bavituximab in combination with chemotherapy in patients with advanced cancer were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting.

2 Jun 2008

Medarex announces preliminary data for investigational anti-PD-1 antibody

Medarex, Inc. has announced preliminary data from an ongoing Phase 1 study of MDX-1106 (ONO-4538: development code of Ono Pharmaceutical Co., Ltd.), a fully human anti-PD-1 antibody.

2 Jun 2008

Clinical Trial News and Research

Guidelines for reporting health research have little funding

Seven biomarkers that may help pinpoint prostate cancer recurrence found

Drug rapamycin reverses mental retardation caused by tuberous sclerosis complex

Could Gleevec help stroke victims?

Patient's own infection-fighting T cells put late-stage melanoma into long-term remission

New findings show obesity-related complications improve six months following gastric banding procedure

Seven biomarkers found that predict with 86 percent accuracy prostate cancer recurrence

University of California, San Francisco embraces web 2.0 for health information

Scaling and root planing dental treatment safe for pregnant women

Maxygen receives approval for trial of factor VIIa in UK

Local doctors trial the coil to prevent womb cancer

Heart Failure 2008 - Congress to address a heart condition whose prevalence is increasing with 'exponential growth'

St. John's wort not effective for treating ADHD

New grant to enable University of Rochester to increase HIV research by 25 percent

U of M sets new standard of care for recessive dystrophic epidermolysis bullosa

ThromboGenics and BioInvent report positive results for anti-PlGF cancer therapeutic TB-403

Study looks at the role of metformin as possible anti-tumor agent

New breast cancer drug combo shrinks aggressive tumours

Peregrine Pharmaceuticals updates on Bavituximab breast cancer study

Medarex announces preliminary data for investigational anti-PD-1 antibody

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