Clinical Trial News and Research

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New type of imaging system illuminates tumors to nearly one-trillionth of a meter

Doctors' quest to see what is happening inside a living body has been hampered by the limits on detecting tiny components of internal structures and events.

1 Apr 2008

Eli Lilly starts trial of treatment of mild to moderate Alzheimer's disease

Eli Lilly and Company has announced the start of a Phase III clinical trial studying LY450139, an investigational gamma secretase inhibitor for the treatment of mild to moderate Alzheimer's disease.

1 Apr 2008

Disappointing resuts for pimecrolimus, investigational anti-restenosis drug

A new medication that researchers had hoped would reduce the risk of arterial renarrowing after stenting has turned in a disappointing performance in a multicenter clinical trial, but the multi-reservoir stent that was used to deliver the drug is still considered promising.

1 Apr 2008

Significant reductions in mortality shown using blood pressure-lowering treatment in very elderly

Lowering the blood pressure of elderly patients could cut their total mortality by a fifth and their rate of cardiovascular events by a third, according to a new study presented at the American College of Cardiology in Chicago and published simultaneously in the New England Journal of Medicine.

1 Apr 2008

Study shows Actos prevented progression of atherosclerotic plaque volume in patients

New data from a clinical trial using intravascular ultrasound (IVUS) technology found that in patients living with type 2 diabetes, ACTOS (pioglitazone HCl) reduced the atherosclerotic burden in the coronary arteries compared to glimepiride, and prevented progression compared to baseline.

1 Apr 2008

Fasting for two days protects healthy cells against chemotherapy

The chemotherapy worked as intended on cancer, extending the lifespan of mice injected with aggressive human tumors, reported a group led by Valter Longo of the University of Southern California.

1 Apr 2008

Appendix removed through a patient's vagina

On March 26, 2008, surgeons at UC San Diego Medical Center removed an inflamed appendix through a patient's vagina, a first in the United States.

From Evident Corporation - Life Sciences 31 Mar 2008

When should children infected with HIV start medication?

The advent of effective medications for treating HIV dramatically improved the outlook for both adults and children infected with HIV who had access to treatment, but the optimal timing for starting treatment remains controversial, particularly in children.

25 Mar 2008

Cancer treatments in phase 3 trials successful up to half of the time

About one-fourth to one-half of new cancer treatments that reach assessment in phase 3 randomized clinical trials are eventually proven successful, according to a report in the March 24 issue of Archives of Internal Medicine.

25 Mar 2008

NanoBio completes interim analysis of phase 2 clinical trial in onychomycosis

NanoBio Corporation has announced that it has seen promising results from an interim analysis of its phase 2 study of NB-002, a topical lotion for onychomycosis (nail fungus). Although the details remain confidential, the results clearly justify completing the study, according to NanoBio scientists

24 Mar 2008

EpiCept announces opinion by European Regulatory Authority on Ceplene

EpiCept Corporation has announced that the European Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency (EMEA), has issued, as expected following the trend vote announced last month, a negative opinion regarding the marketing authorization application (MAA) for Ceplene (histamine dihydrochloride) for the remission maintenance and prevention of relapse of patients with Acute Myeloid Leukemia (AML) in first remission.

24 Mar 2008

NicOx signs agreement for commercial manufacture of Naproxcinod drug substance

NicOx S.A. (Euronext Paris: COX) has announced it has signed an agreement with the fine chemical company Archimica, for the commercial manufacturing and supply of naproxcinod drug substance (or active pharmaceutical ingredient, API).

20 Mar 2008

New medical adhesive

The U.S. Food and Drug Administration today approved a new medical adhesive (a fibrin sealant) called Artiss for use in attaching skin grafts onto burn patients.

20 Mar 2008

New choices bring wider range of women to family planning

A study appearing in the March 2008 issue of the journal Contraception reports that the Standard Days Method, a natural family planning method developed by researchers from Georgetown University Medical Center's Institute for Reproductive Health, brings new women to family planning.

19 Mar 2008

MedImmune advances clinical development of antibody targeting interleukin-9 in patients with asthma

MedImmune has announced that its clinical program studying an investigational treatment targeting interleukin-9 (IL-9) has advanced with the start of a new trial in patients with asthma.

19 Mar 2008

Lithium chloride slows development of inclusion body myositis

A new UC Irvine study finds that lithium chloride, a drug used to treat bipolar disorder, can slow the development of inclusion body myositis, a skeletal muscle disease that affects the elderly.

19 Mar 2008

Only two per cent of 700 paediatric drug trials included independent safety checks

Only two per cent of paediatric drug trials reported that they had established independent safety monitoring committees that can help lead to the early detection of adverse drug reactions, according to a major review in the April issue of Acta Paediatrica.

19 Mar 2008

Genetic counselors turn to unconventional counseling to meet demand for genetic testing

Imagine receiving genetic test results for a disease you could develop later in life without having anyone with whom to discuss your options for managing the risk.

18 Mar 2008

First clinical trial data of a fully bioabsorbable drug-eluting stent

Data published today in The Lancet from ABSORB, the world's first clinical trial of a fully bioabsorbable drug eluting stent for the treatment of coronary artery disease, demonstrated no stent thrombosis, no clinically driven target lesion revascularizations (re-treatment of a diseased lesion), and a low (3.3 percent) rate of major adverse cardiac events (MACE) in 30 patients out to one year.

14 Mar 2008

MGH initiates trial to reverse type 1 diabetes

Scientists at the Massachusetts General Hospital (MGH) have initiated a phase 1 clinical trial to reverse type 1 diabetes.

14 Mar 2008

Clinical Trial News and Research

New type of imaging system illuminates tumors to nearly one-trillionth of a meter

Eli Lilly starts trial of treatment of mild to moderate Alzheimer's disease

Disappointing resuts for pimecrolimus, investigational anti-restenosis drug

Significant reductions in mortality shown using blood pressure-lowering treatment in very elderly

Study shows Actos prevented progression of atherosclerotic plaque volume in patients

Fasting for two days protects healthy cells against chemotherapy

Appendix removed through a patient's vagina

When should children infected with HIV start medication?

Cancer treatments in phase 3 trials successful up to half of the time

NanoBio completes interim analysis of phase 2 clinical trial in onychomycosis

EpiCept announces opinion by European Regulatory Authority on Ceplene

NicOx signs agreement for commercial manufacture of Naproxcinod drug substance

New medical adhesive

New choices bring wider range of women to family planning

MedImmune advances clinical development of antibody targeting interleukin-9 in patients with asthma

Lithium chloride slows development of inclusion body myositis

Only two per cent of 700 paediatric drug trials included independent safety checks

Genetic counselors turn to unconventional counseling to meet demand for genetic testing

First clinical trial data of a fully bioabsorbable drug-eluting stent

MGH initiates trial to reverse type 1 diabetes

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