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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

New clues to why some kinds of leukemia are more aggressive and deadly than others are coming from research examining the types of genetic damage that allow some blood cells to grow out of control, scientists report.

23 Apr 2006

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

A team of scientists from Lawrence Berkeley National Laboratory and the Scripps Research Institute has determined the crystal structure and molecular mechanisms of a key part of WRN, a protein that protects humans from premature aging and cancer.

23 Apr 2006

Magnetic nanotechnology holds promise in fighting cancer

Detecting cancer and reinventing computing are two challenges that seemingly have little, if anything, to do with each other. That is, unless you are a nanotechnologist like Shan Wang, an associate professor of materials science and engineering and of electrical engineering at Stanford.

20 Apr 2006

Genetic data from an island population proves to be a useful tool in understanding disease

With fewer than 4,000 residents, the genetically isolated Micronesian island of Kosrae, in the West Pacific, provides an ideal population in which to research heritability of disease.

20 Apr 2006

Researchers find gene connected to Lupus

Researchers at the University of Minnesota have identified a variant of a gene that is present in most people with lupus, a complex and chronic autoimmune disease.

20 Apr 2006

Primagen awarded U.S. patent for using mitochondrial DNA quantification as biomarker

Primagen Holding BV has announced that the U.S. Patent and Trademark Office has granted a patent for its Mitox mitochondrial DNA quantification technology as biomarkers for efficacy and adverse events of treatment.

19 Apr 2006

St. Jude develop strategy to speed future development of more effective and less toxic treatments for medulloblastoma

Investigators at St. Jude Children’s Research Hospital have developed a strategy to speed future development of more effective and less toxic treatments for medulloblastoma, a type of brain cancer. Medulloblastomas arise in the back of the brain and account for about 20 percent of childhood brain tumors.

18 Apr 2006

Fast tracking the healing process for common ear infections

The research will aim to understand why some eardrums heal by themselves (and why some do not heal at all) by identifying which genes are responsible for the wound-healing process of an infected human ear drum.

18 Apr 2006

Important new global mechanism for gene repression

Most of the time in most cells of the body, the great majority of genes are silenced, locked away within the compacted but orderly material that makes up chromosomes.

18 Apr 2006

Common gene variation associated with an increased risk for obesity

A pioneering statistical technique developed at the Harvard School of Public Health (HSPH) has helped identify a common gene variation associated with an increased risk for obesity.

18 Apr 2006

Chimpanzees and humans have gene variant, for different reasons

Gene variants determine which humans and which chimpanzees can taste bitter substances. For humans, this taste sensitivity may influence nutritional choices and ultimately their health, as well as behaviors, such as smoking.

18 Apr 2006

First gene therapy human trial in the United States for a form of muscular dystrophy under way

The clinical trial for Duchenne muscular dystrophy (DMD) tests the safety and effectiveness of a therapy that was developed over two decades by scientists at the University of North Carolina Chapel Hill's School of Medicine and the University of Pittsburgh.

16 Apr 2006

Doses of DNA-gene-coated gold particles protect against harmful protein implicated in Alzheimer's disease

Doses of DNA-gene-coated gold particles protect mice against a protein implicated in Alzheimer's disease, researchers at UT Southwestern Medical Center have found.

16 Apr 2006

Excessive adiposity, calorie restriction, and aging

Can eating a low-calorie yet nutritionally balanced diet extend human life? Preliminary research suggests it might, so researchers at Washington University School of Medicine in St. Louis are launching a long-term study to find out.

16 Apr 2006

Active ingredient in soy may explain why Asians have lower rates of obesity and cancer

A single nutrient found in soy products elicits changes in gene behavior that permanently reduce an embryo's risk of becoming obese later in life, according to an animal study at Duke University Medical Center.

13 Apr 2006

Swansong - dead swan a foreigner and one and only so far

The dead swan found in Fife in Scotland on March 29th has now been identified by DNA tests as one of a migratory species, quelling fears that it was the harbinger of the first outbreak in the UK.

12 Apr 2006

Researchers identify the role of a protein in hemoglobin gene silencing

Virginia Commonwealth University Massey Cancer Center researchers have identified the role of a protein in hemoglobin gene silencing that may one day be a potential target for the treatment of genetic blood disorders like sickle-cell anemia and beta-thalassemia on the molecular level.

11 Apr 2006

New model of p53 regulation has important implications for the development of anticancer drugs

Genetically engineered mice convinced scientists at the Salk Institute for Biological Studies that it was time to overhaul widely held beliefs about how a powerful tumor suppressor called p53 is controlled in cells. Their new model of p53 regulation has important implications for the development of anticancer drugs.

11 Apr 2006

DNA "dark state" findings help explain evolution of life

Chemists at Oregon State University have pioneered a controversial theory about how supposedly-stable DNA bases can be pushed into a "dark state" in which they are highly vulnerable to damage from ultraviolet radiation - an idea that has challenged some of the most basic concepts of modern biochemistry.

11 Apr 2006

Gene variant doubles risk for obsessive-compulsive disorder

Scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have identified a previously unknown gene variant that doubles an individual's risk for obsessive-compulsive disorder (OCD).

11 Apr 2006

DNA News and Research

Further Reading

Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

Magnetic nanotechnology holds promise in fighting cancer

Genetic data from an island population proves to be a useful tool in understanding disease

Researchers find gene connected to Lupus

Primagen awarded U.S. patent for using mitochondrial DNA quantification as biomarker

St. Jude develop strategy to speed future development of more effective and less toxic treatments for medulloblastoma

Fast tracking the healing process for common ear infections

Important new global mechanism for gene repression

Common gene variation associated with an increased risk for obesity

Chimpanzees and humans have gene variant, for different reasons

First gene therapy human trial in the United States for a form of muscular dystrophy under way

Doses of DNA-gene-coated gold particles protect against harmful protein implicated in Alzheimer's disease

Excessive adiposity, calorie restriction, and aging

Active ingredient in soy may explain why Asians have lower rates of obesity and cancer

Swansong - dead swan a foreigner and one and only so far

Researchers identify the role of a protein in hemoglobin gene silencing

New model of p53 regulation has important implications for the development of anticancer drugs

DNA "dark state" findings help explain evolution of life

Gene variant doubles risk for obsessive-compulsive disorder

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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