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Novel PF74 molecule effectively targets HIV capsid protein

Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication.

9 Apr 2021

Novel diarylamides show promise as orally active diuretics to treat hyponatremia

Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics.

8 Apr 2021

Acrylamide-based novel DHODH inhibitors as potential treatment for rheumatoid arthritis

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS).

8 Apr 2021

Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis

Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer andimmunological diseases, such asrheumatoid arthritis(RA), psoriasis andmultiple sclerosis(MS).

8 Apr 2021

Breath Analysis: How Could it Improve Healthcare and Diagnosis?

In this interview, News-Medical talks to Santi Dominguez (SD) and Michael Graz (MG), CEOs at Imspex Diagnostics and Imspex Medical respectively, about the role breath analysis has to play in healthcare and diagnosis.

From Imspex Medical 8 Apr 2021

Hydrogels offer new hope for cancer treatment

Hydrogels are often used as drug delivery systems, but to be effective carriers for anti-cancer drugs, they need to be responsive to varied stimuli in the tumor microenvironment.

8 Apr 2021

Urolithin A shows promise to slow progression of Duchenne Muscle Dystrophy

Progression of Duchenne Muscle Dystrophy (DMD) can be delayed in mice by supplementing their diets with Urolithin A, according to new results reported today.

7 Apr 2021

Neurotechnology combined with saliva testing improves accuracy in measuring psychoactive effects of cannabis

A new study, released today in the scientific journal Advances in Therapy is providing critical evidence that neurotechnology combined with saliva testing can drastically reduce the likelihood of falsely determining cannabis impairment due to THC residual detection.

7 Apr 2021

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

A team of scientists from the USA and Sweden has recently screened 8 million small molecule inhibitors against SARS-CoV-2.

5 Apr 2021

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the SARS-CoV-2.

5 Apr 2021

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

James McKerrow, MD, PhD, dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego, has long studied neglected tropical diseases -- chronic and disabling parasitic infections that primarily affect poor and underserved communities in developing nations.

3 Apr 2021

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

A new study describes the identification of new compounds from a library, with inhibitory activity against several coronaviruses. This study shows the utility of this method, besides identifying compounds that not only inhibit viral shedding in SARS-CoV-2 cultures, but have an immunomodulatory effect that may be useful in mitigating the damaging cytokine storm typical of severe or critical COVID-19.

2 Apr 2021

Comparative study of SARS, MERS, BAT‐SARS, and SARS-CoV-2

Even though a comparative study on the genomic sequences of SARS-CoV, MERS-CoV, and SARS-CoV-2 is available, there is a gap in the research in regards to the comparison between four types of coronaviruses, namely, SARS-CoV, MERS-CoV, BAT-CoV, and SARS-CoV-2. A new study, which deals with the genomic comparison between the sequence of the above-stated four types of coronaviruses, has been published in the Journal of Medical Virology.

2 Apr 2021

Could a flavonoid found in common fruit and vegetables combat COVID-19?

Researchers in India have gathered and presented a large body of evidence highlight quercetin – a flavonoid molecule found in many common fruits and vegetables – may be developed into drug therapies used to combat COVID-19.

1 Apr 2021

Novel molecule could offer a new way to fight against SARS coronavirus 2

Scientists at the University of Bonn and the caesar research center have isolated a molecule that might open new avenues in the fight against SARS coronavirus 2. The active ingredient binds to the spike protein that the virus uses to dock to the cells it infects.

27 Mar 2021

UArizona researcher finds a unique approach to tackle both Alzheimer’s disease and diabetes

A University of Arizona Health Sciences researcher examined the role of cholesterol in both Alzheimer's disease and Type 2 diabetes to identify a small molecule that may help regulate cholesterol levels in the brain, making it a potential new therapeutic target for Alzheimer's disease.

25 Mar 2021

Near-infrared hyperspectral imaging technique can facilitate the diagnosis of fatty liver diseases

Excessive fat accumulation in the liver can lead to serious medical problems, including liver failure. Thus, understanding the distribution of lipids within the liver is a critical step in diagnosing fatty liver diseases.

25 Mar 2021

New compound may provide a basis for drug development against COVID-19

SARS-CoV-2, the virus responsible for the COVID-19 pandemic, arrived one year ago and turned our lives upside-down.

24 Mar 2021

Three commonly used antiviral drugs potentially effective at preventing replication of SARS-CoV-2

An international team of researchers has found that three commonly used antiviral and antimalarial drugs are effective in vitro at preventing replication of SARS-CoV-2, the virus that causes COVID-19.

24 Mar 2021

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

Acriflavine is traditionally employed as a topical antiseptic, though has more recently been implicated as an antiviral agent at low doses, potentially by stimulating the production of interferon. In a new study recently uploaded to the bioRxiv* preprint server, the application of the drug to SARS-CoV-2 infection is investigated, demonstrating a broad activity towards a range of other betacoronaviruses.

24 Mar 2021

Compound News and Research

Novel PF74 molecule effectively targets HIV capsid protein

Novel diarylamides show promise as orally active diuretics to treat hyponatremia

Acrylamide-based novel DHODH inhibitors as potential treatment for rheumatoid arthritis

Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis

Breath Analysis: How Could it Improve Healthcare and Diagnosis?

Hydrogels offer new hope for cancer treatment

Urolithin A shows promise to slow progression of Duchenne Muscle Dystrophy

Neurotechnology combined with saliva testing improves accuracy in measuring psychoactive effects of cannabis

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

Comparative study of SARS, MERS, BAT‐SARS, and SARS-CoV-2

Could a flavonoid found in common fruit and vegetables combat COVID-19?

Novel molecule could offer a new way to fight against SARS coronavirus 2

UArizona researcher finds a unique approach to tackle both Alzheimer’s disease and diabetes

Near-infrared hyperspectral imaging technique can facilitate the diagnosis of fatty liver diseases

New compound may provide a basis for drug development against COVID-19

Three commonly used antiviral drugs potentially effective at preventing replication of SARS-CoV-2

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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