Genomic News and Research

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Study to measure the impact of whole genome sequencing in patients with cardiovascular disease

Henry Ford Health research teams are launching a series of clinical studies in partnership with Illumina Inc., a global leader in DNA sequencing and array-based technologies, to assess the impact of comprehensive genomic testing in various disease areas.

11 Apr 2023

SARS-CoV-2 may exploit multiple receptors and pathways across various tissues, age groups

A study led by Mount Sinai researchers Dr. Bin Zhang, the Willard T.C. Johnson Research Professor of Neurogenetics, and Dr. Christian Forst, an Associate Professor in the Department of Genetics and Genomic Sciences, have identified potential novel receptors for SARS-CoV-2 and unveiled their tissue-specific and age-dependent expression.

11 Apr 2023

Study opens new possibilities of tailoring radiopharmaceutical treatment to neuroendocrine cancer patients

A simple blood draw can provide physicians with valuable information that can determine if peptide receptor radionuclide therapy (PRRT) is likely to be effective in a patient with neuroendocrine cancer.

7 Apr 2023

Is mRNA decoding in humans structurally and kinetically distinct from bacteria?

Researchers examined molecular-level differences in ribosomal translational fidelity between humans and bacteria.

7 Apr 2023

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict — before treatment begins — how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

Analyzing DNA changes in the blood can improve prediction of type 2 diabetes risk

Analyzing changes to DNA in the blood can improve the ability to predict a person's risk of developing type 2 diabetes within a decade.

6 Apr 2023

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Mosaic Therapeutics, an oncology therapeutics company dedicated to resolving cancer’s complexity to power new treatments for patients, today announced the close of its $28 million series A funding round.

From Mosaic Therapeutics 4 Apr 2023

CRISPR screens reveal genetic determinants of PARP inhibition in prostate cancer

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive.

4 Apr 2023

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Company developing targeted oncology therapies spun out of world-leading research at the Wellcome Sanger Institute, in collaboration with the Netherlands Cancer Institute.

From Mosaic Therapeutics 4 Apr 2023

Endothelial deletion of the Wt1 gene affects coronary vessel formation and myocardial development

How is the mammals' heart formed? What role do endothelial cells play? Do the same pathways and genes involved in the formation of the embryonic heart also play a role in repair processes?

4 Apr 2023

Overcoming challenges in flavivirus vaccine development: Exploring modern vaccine types for Dengue, Zika, and beyond

Researchers discuss the challenges impeding the development of vaccines against flaviviruses.

4 Apr 2023

BU researcher wins $3.9 million NIH grant to develop novel therapeutic modalities for Alzheimer's

Julia TCW, PhD, assistant professor of pharmacology & experimental therapeutics at Boston University Chobanian & Avedisian School of Medicine, has received a five-year, $3.9 million grant from the National Institutes of Health's National Institute on Aging.

3 Apr 2023

Yale-led team creates new resource that is an important step toward personalized care

Each person has about 4 million sequence differences in their genome relative to the reference human genome.

3 Apr 2023

Researchers develop new method to make rare cell types and disease patterns visible in tissue

The human body contains more than 30 trillion cells. Until recently, the sheer number of cells in the organism meant that approaches to understanding human diseases and developmental processes based on the analysis of single cells were a futuristic vision.

31 Mar 2023

$3.2 million grant aids in the study of genetic testing approach to close racial disparity gaps in cancer care

With the aid of a near $3.2 million National Cancer Institute grant (R01CA277599) recently awarded, investigators from the state's leading cancer program, Rutgers Cancer Institute of New Jersey,  and Georgetown University's Lombardi Comprehensive Cancer Center, both NCI-designated Comprehensive Cancer Centers, will work to close racial disparity gaps in cancer care delivery by examining a novel approach to genetic testing and care based on community-identified needs.

30 Mar 2023

AI outperforms the leading tools in predicting enzyme function

A new artificial intelligence tool can predict the functions of enzymes based on their amino acid sequences, even when the enzymes are unstudied or poorly understood.

30 Mar 2023

A novel species of dependoparvovirus has been identified in monk parakeets in Madrid

A novel dependoparvovirus identified from 28 healthy monk parakeets from urban regions of Spain.

30 Mar 2023

Can poor diet and lifestyle behaviors modify genomic susceptibility to impulsivity?

Researchers evaluated the effects of poor diet quality and lifestyle behaviors on modifying the genomic susceptibility to impulsivity.

30 Mar 2023

Study finds minimal impact of SARS-CoV-2 genome variability on current diagnostic molecular systems

The authors of a new study under review at the journal Scientific Reports and currently posted to the Research Square preprint* server proposed a novel analysis pipeline to help identify mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription-polymerase chain reaction (RT-PCR) primer regions.

29 Mar 2023

Study reveals wastewater as potential origin for mobile antibiotic resistance genes

Researchers found new evidence that wastewaters are a feasible environment for mobilizing antibiotic resistance genes.

29 Mar 2023

Genomic News and Research

Study to measure the impact of whole genome sequencing in patients with cardiovascular disease

SARS-CoV-2 may exploit multiple receptors and pathways across various tissues, age groups

Study opens new possibilities of tailoring radiopharmaceutical treatment to neuroendocrine cancer patients

Is mRNA decoding in humans structurally and kinetically distinct from bacteria?

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

Analyzing DNA changes in the blood can improve prediction of type 2 diabetes risk

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

CRISPR screens reveal genetic determinants of PARP inhibition in prostate cancer

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Endothelial deletion of the Wt1 gene affects coronary vessel formation and myocardial development

Overcoming challenges in flavivirus vaccine development: Exploring modern vaccine types for Dengue, Zika, and beyond

BU researcher wins $3.9 million NIH grant to develop novel therapeutic modalities for Alzheimer's

Yale-led team creates new resource that is an important step toward personalized care

Researchers develop new method to make rare cell types and disease patterns visible in tissue

$3.2 million grant aids in the study of genetic testing approach to close racial disparity gaps in cancer care

AI outperforms the leading tools in predicting enzyme function

A novel species of dependoparvovirus has been identified in monk parakeets in Madrid

Can poor diet and lifestyle behaviors modify genomic susceptibility to impulsivity?

Study finds minimal impact of SARS-CoV-2 genome variability on current diagnostic molecular systems

Study reveals wastewater as potential origin for mobile antibiotic resistance genes

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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