Hormone News and Research

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A hormone is a chemical released by one or more cells that affects cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. It is essentially a chemical messenger that transports a signal from one cell to another.

Study provides new insights for the future development of oral insulin pill

WEHI researchers in Melbourne have answered a 100-year-old question in diabetes research: can a molecule different to insulin have the same effect? The findings provide important insights for the future development of an oral insulin pill.

12 Dec 2022

Addition of capivasertib to fulvestrant doubles progression-free survival in HR-positive breast cancer patients

In patients with hormone receptor (HR)-positive, HER2-negative tumors resistant to aromatase inhibitors, addition of the investigational AKT inhibitor capivasertib to fulvestrant (Faslodex) doubled the median progression-free survival compared with placebo plus fulvestrant in the phase III CAPItello-291 clinical trial, according to results presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

9 Dec 2022

Estrogen replacement therapy may be a tool to mitigate delirium

Delirium is common among women with urinary tract infections (UTIs) - especially those who have experienced menopause.

8 Dec 2022

New Clinical Practice Guideline offers recommendations to manage hypoglycemia in people with diabetes

People with diabetes are benefiting from advances in medications and technologies to lower their risk of hypoglycemia, according to a Clinical Practice Guideline issued today by the Endocrine Society.

7 Dec 2022

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Patients with localized, hormone receptor-positive, HER2-low breast cancer treated with trastuzumab deruxtecan (T-DXd, Enhertu) in the neoadjuvant setting had an overall response rate of 75 percent in the absence of anastrozole and 63 percent in combination with anastrozole, according to results from the phase II TRIO-US B-12 TALENT trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Genomic assay can help identify breast cancer patients who may benefit from ovarian suppression therapy

Among premenopausal women with hormone receptor (HR)-positive, early-stage breast cancer enrolled in the SOFT trial, those with a high score on a genomic assay called Breast Cancer Index (BCI) had increased risk of distant recurrence, and those with low BCI benefited more from the addition of ovarian suppression therapy to endocrine therapy after 12 years of follow-up, according to data presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Research explores how alignment of endothelial cells plays a role in cancer metastasis

Preventing metastasis – the development of cancer cells beyond their original location – remains one of the major goals of current cancer research.

6 Dec 2022

UHN’s Ajmera Transplant Centre performed a groundbreaking parathyroid transplant

The Ajmera Transplant Centre at University Health Network (UHN) has performed a groundbreaking parathyroid transplant, in a patient who suffered from a severe form of hypoparathyroidism – when there is little or no parathyroid function.

5 Dec 2022

Moderate alcohol intake may affect lipoprotein metabolism

A recent Nutrients journal study evaluated the impact of 1-2 drinks of alcohol per day on cardiovascular biomarkers in the cross-over intervention, prospective, and assessor-blinded trial called the Metabolic Imprints of Alcoholic Beverages (MetAl).

30 Nov 2022

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the worst in otherwise peaceable cells? Or is it a back-and-forth, a dialogue between the two?

30 Nov 2022

Eating healthy plant-based diet linked to reduced risk of colorectal cancer

Eating a plant-based diet rich in healthy plant foods - such as whole grains, vegetables, and legumes - and low in unhealthy plant foods - including refined grains, fruit juices, and added sugars - is associated with a lower risk of colorectal cancer in men.

29 Nov 2022

New microfluidic Organ Chip platform replicates the human vaginal tissue microenvironment

The human microbiome has been a hot topic over the last decade, with research pointing to disrupted bacterial communities as culprits for a host of maladies including irritable bowel syndrome, eczema, and autoimmune diseases.

28 Nov 2022

Single drug compound may offer a promising new strategy for treating prostate cancer patients

A single drug compound simultaneously attacks hard-to-treat prostate cancer on several fronts, according to a new study in mice and human cells.

23 Nov 2022

Using induced pluripotent stem cells to recreate the adrenal gland in a petri dish

Sitting atop the kidneys, the adrenal gland plays a pivotal role in maintaining a healthy body. Responding to signals from the brain, the gland secretes hormones that support critical functions like blood pressure, metabolism, and fertility.

21 Nov 2022

FDA approves first-ever type 1 diabetes delaying drug Tzield (teplizumab-mzwv)

On November 17, 2022, the US Food and Drug Administration (FDA) approved a pathbreaking new drug called Tzield. This injectable formulation contains a combination of two drugs that could push back the onset of type 1 diabetes (T1D) in adults at stage 3 and children aged eight years or more at stage 2.

20 Nov 2022

Potential effects of nonoral versus oral gender-affirming estrogen therapy

A comprehensive review of research into the delivery method of estrogen treatment (e.g., oral, intramuscular injection, transdermal patch, etc.) and cardiovascular risk in transgender women and gender-diverse people found that treatment route may affect heart health, but there is not enough available data for metanalysis. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology. It was chosen as an APSselect article for November.

17 Nov 2022

National Institutes of Health funds a five-year, $11 million initiative

The conversations between our bone and muscle change as we age, and both are the weaker for it, Medical College of Georgia scientists say.

17 Nov 2022

Diet containing excess salt can contribute to increased levels of stress, study shows

A diet containing lots of salt can contribute to increased levels of stress, a new study shows.

16 Nov 2022

Study describes risk factors for people with chronic pancreatitis to develop diabetes

A new study by Cedars-Sinai investigators describes risk factors that could make it more likely for people who have chronic pancreatitis, an ongoing inflammation of the pancreas, to develop diabetes. The findings are published in Diabetes Care.

16 Nov 2022

Research in young rats shows how hormonal contraceptives may affect the brain

Reproductive health experts consider hormonal contraceptives good choices for adolescents because they're safe and highly effective at preventing pregnancy, but one aspect of their effect on the teenage body remains a mystery – whether and how they modify the developing brain.

16 Nov 2022

Hormone News and Research

Further Reading

Study provides new insights for the future development of oral insulin pill

Addition of capivasertib to fulvestrant doubles progression-free survival in HR-positive breast cancer patients

Estrogen replacement therapy may be a tool to mitigate delirium

New Clinical Practice Guideline offers recommendations to manage hypoglycemia in people with diabetes

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Genomic assay can help identify breast cancer patients who may benefit from ovarian suppression therapy

Research explores how alignment of endothelial cells plays a role in cancer metastasis

UHN’s Ajmera Transplant Centre performed a groundbreaking parathyroid transplant

Moderate alcohol intake may affect lipoprotein metabolism

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

Eating healthy plant-based diet linked to reduced risk of colorectal cancer

New microfluidic Organ Chip platform replicates the human vaginal tissue microenvironment

Single drug compound may offer a promising new strategy for treating prostate cancer patients

Using induced pluripotent stem cells to recreate the adrenal gland in a petri dish

FDA approves first-ever type 1 diabetes delaying drug Tzield (teplizumab-mzwv)

Potential effects of nonoral versus oral gender-affirming estrogen therapy

National Institutes of Health funds a five-year, $11 million initiative

Diet containing excess salt can contribute to increased levels of stress, study shows

Study describes risk factors for people with chronic pancreatitis to develop diabetes

Research in young rats shows how hormonal contraceptives may affect the brain

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