Mutation News and Research

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Gut virome may warn of a serious and often fatal disease in preterm infants

Immediately after birth, human infants begin to develop a complex, interwoven fabric of microbes in their gut.

26 Apr 2022

UNIGE scientists develop a novel tool to visualize palmitoylation process in living cells

Peripheral membrane proteins have the particularity of temporarily binding to cell membranes, a necessary step for them to be able to fulfil their biological function.

26 Apr 2022

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Researchers conducted an in vitro analysis to assess the host cell furin-mediated cleavability of the spike protein of the SARS-CoV-2 Omicron (B.1.529) variant.

26 Apr 2022

Researchers develop new platform capable of mitochondrial DNA editing

Researchers from the Center for Genome Engineering within the Institute for Basic Science developed a new gene-editing platform called transcription activator-like effector-linked deaminases, or TALED.

25 Apr 2022

New study shows racial differences in breast cancer genomic profiling

A new study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine has found that Black women with metastatic breast cancer were less likely to have tumors with treatable genetic variations than white and Asian women.

25 Apr 2022

Species differences in somatic mutations shed light on aging

A recent study published in the journal Nature aimed to elucidate, through a comparative analysis, the diversity in mutagenesis across different species, and the long-established hypothesis regarding evolution in the rates of somatic mutation, as well as their role in cancer and aging.

25 Apr 2022

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

A recent review paper, published in the MDPI’s specialized journal COVID, highlights key features of the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and examines the potential and roadblocks in using renewable marine resources in the fight against the coronavirus disease 2019 (COVID-19).

24 Apr 2022

Metabolomics and multi-omics perspective of cancer show promise for finding new treatments

While cancer is a genetic disease, the genetic component is just one piece of the puzzle - and researchers need to consider environmental and metabolic factors as well, according to a research review by a leading expert at the University of Alberta.

22 Apr 2022

Study suggests SARS-CoV-2 is undergoing evolutionary changes at the functional RNA level in addition to the amino acid level

Researchers demonstrated SARS-CoV-2 evolution at the transcriptional level.

22 Apr 2022

Antibody escape in SARS-CoV-2 Omicron spike protein

Researchers examined antibody escape and cross-domain stabilization in the SARS-CoV-2 Omicron spike protein.

22 Apr 2022

Antibody-based treatment, endogenous immune responses, and within-host SARS-CoV-2 evolution in immunocompromised patients

Researchers investigated the interplay of all the factors responsible for within-host evolution of SARS-CoV-2 variants in immunocompromised patients.

21 Apr 2022

Evolution of SARS-CoV-2 variants

Research has demonstrated the evolutionary process and biology of SARS-CoV-2, the causative pathogen of the COVID-19 pandemic.

21 Apr 2022

Study evaluates SARS-CoV-2 whole genome data from patients and staff in the VA Northeast Ohio Healthcare System

Researchers surveyed over 360 COVID-19 patients to characterize the SARS-CoV-2 genomic sequence diversity of individual infections.

21 Apr 2022

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Alzheimer's disease is marked by a loss of functional neurons in the brain. But what causes this loss? Through single-cell genome sequencing, researchers at Boston Children's Hospital, Brigham and Women's Hospital, and the Broad Institute show that people with Alzheimer's have an abundance of newly acquired mutations in their neurons - more than people of the same age without Alzheimer's, and enough to disable genes important to brain function.

20 Apr 2022

Lab grown, self-renewing muscle stem cells can repair muscle tissue damage in mice

In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

20 Apr 2022

Investigating the impact of SARS-CoV-2 Omicron spike mutations

Researchers investigated the impact of amino acid substitutions of SARS-CoV-2 Omicron on spike protein function, processing, and neutralization susceptibility.

20 Apr 2022

Study investigates co-metabolism during SARS-CoV-2 infection

In a new study, researchers investigated host-virus co-metabolism during a SARS-CoV-2 infection.

20 Apr 2022

Study demonstrates subset of vaccine-induced HLA-A*24:02-restricted T cells exhibits enhanced reactivity against the Omicron BA.1 variant

Researchers characterized vaccine-induced T cell response specific for spike proteins of several SARS-CoV-2 variants.

20 Apr 2022

CAR T-Cell Therapy: The Future of Cancer and HIV Treatment?

In this interview, News-Medical speaks to Professor Jun Huang about CAR T-cell therapy and its future as a potential treatment for cancer or HIV.

20 Apr 2022

Little-known protein found to play a role in common neurodegenerative disorder

Scientists have known for years that amyloid fibrils - fibrous, ropelike structures formed by closely linked protein molecules - are present in the brains of patients with Alzheimer's and Parkinson's diseases and likely play a role in the progression of these disorders.

20 Apr 2022

Mutation News and Research

Gut virome may warn of a serious and often fatal disease in preterm infants

UNIGE scientists develop a novel tool to visualize palmitoylation process in living cells

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Researchers develop new platform capable of mitochondrial DNA editing

New study shows racial differences in breast cancer genomic profiling

Species differences in somatic mutations shed light on aging

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

Metabolomics and multi-omics perspective of cancer show promise for finding new treatments

Study suggests SARS-CoV-2 is undergoing evolutionary changes at the functional RNA level in addition to the amino acid level

Antibody escape in SARS-CoV-2 Omicron spike protein

Antibody-based treatment, endogenous immune responses, and within-host SARS-CoV-2 evolution in immunocompromised patients

Evolution of SARS-CoV-2 variants

Study evaluates SARS-CoV-2 whole genome data from patients and staff in the VA Northeast Ohio Healthcare System

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Lab grown, self-renewing muscle stem cells can repair muscle tissue damage in mice

Investigating the impact of SARS-CoV-2 Omicron spike mutations

Study investigates co-metabolism during SARS-CoV-2 infection

Study demonstrates subset of vaccine-induced HLA-A*24:02-restricted T cells exhibits enhanced reactivity against the Omicron BA.1 variant

CAR T-Cell Therapy: The Future of Cancer and HIV Treatment?

Little-known protein found to play a role in common neurodegenerative disorder

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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