Preclinical News and Research

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Using nanoparticles to encapsulate the medication may make corneal grafts more successful

Corneal transplants can be the last step to returning clear vision to many patients suffering from eye disease. Each year, approximately 80,000 corneal transplantations take place in the U.S. Worldwide, more than 184,000 corneal transplantation surgeries are performed annually.

23 Mar 2023

What is the effect of maternal obesity on the brain development of offspring?

Recently, scientists reviewed the mechanisms associated with the maternal microbiome, breast milk composition, maternal and placental metabolites, altered maternal care, and inflammation, which influences the brain development of the offspring.

22 Mar 2023

Gyros Protein Technologies introduces new PurePep EasyClean services to accelerate development and manufacturing of peptide-based drugs

Gyros Protein Technologies AB today announced the launch of three service offerings to support development and manufacturing of peptide-based drugs.

From Gyros Protein Technologies AB 22 Mar 2023

Avanced genome editing technology could be used as a one-time treatment for CD3 delta SCID

A new UCLA-led study suggests that advanced genome editing technology could be used as a one-time treatment for the rare and deadly genetic disease CD3 delta severe combined immunodeficiency.

21 Mar 2023

Upgraded tumor model points the way toward more effective cancer therapies

Tumor cells won't show their true selves in a petri dish, isolated from other cells.

20 Mar 2023

New technique lights up cancerous tumors during surgery

A new technique that combines highly detailed, real-time images of inside the body with a type of infrared light has, for the first time, been used during surgery to differentiate between cancerous tumors and healthy tissue.

20 Mar 2023

Which exercises might reduce pro-inflammatory and enhance anti-inflammatory cytokines in older people with mild cognitive impairment or Alzheimer's disease?

Researchers investigated which exercises might enhance anti-inflammatory cytokines and reduce pro-inflammatory cytokines in patients with dementia or mild cognitive impairment.

17 Mar 2023

Study provides strong support for AAV.NT-3 gene therapy in the management of sarcopenia

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "AAV1.NT-3 gene therapy prevents age-related sarcopenia."

16 Mar 2023

How does soy consumption affect the risk of type 2 diabetes and cardiovascular diseases?

A higher intake of plant protein could effectively improve metabolic health and lower CVD mortality. Recently, scientists in China reviewed existing literature and conducted a meta-analysis to understand the association between increased soy consumption and the risk of T2D and CVDs. This review is available in the journal Nutrients.

15 Mar 2023

Efficacy of a single dose of MVA-BN smallpox vaccine against Mpox

A recent The Lancet Infectious Disease study focussed on estimating the effectiveness of a single dose of MVA-BN against Mpox in England. This observational study was conducted following the large-scale vaccination program that immunized the GBMSM group with the MVA-BN vaccine.

15 Mar 2023

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

A new approach that delivers a "one-two punch" to help T cells attack solid tumors is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania.

15 Mar 2023

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

Houston Methodist scientists reversed infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein, showing further evidence that links high cholesterol to female infertility.

15 Mar 2023

How does dietary intervention affect aging?

Aging is a process that includes multiple interwoven mechanisms that interact with lifestyle factors. A new review seeks to encapsulate the available information on the effect of diet on aging at the cellular level in humans.

14 Mar 2023

Long-term antibiotic therapy for adolescent acne can affect liver metabolism and promote adiposity

A growing body of evidence is showing that the healthy gut microbiome – a community of microorganisms that live together in the gut – influences many aspects of human growth and development, especially during adolescence.

14 Mar 2023

New genetic animal model may inform potential therapeutic options for Down syndrome

National Institutes of Health researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be more similar to the changes seen in humans.

14 Mar 2023

New tool allows researchers to perform genetic screens of cell-cell interactions

Inflammatory neurological diseases, such as multiple sclerosis (MS), can arise when cell-to-cell communication between cells in the central nervous system (CNS) goes awry.

13 Mar 2023

Study creates a radical new view of how immune cells recognize threats

Researchers have created a radical new view of how immune cells recognise threats such as viruses. The discovery could be used to design better vaccines and to gain a deeper insight into autoimmune diseases and allergies.

10 Mar 2023

New technique helps surgeons reconstruct more natural-looking nipples after mastectomy

Weill Cornell Medicine investigators have developed a technique to help surgeons reconstruct more natural-looking nipples for patients who have undergone breast reconstruction after mastectomy to treat breast cancer.

9 Mar 2023

Using tissue-embedded nanoelectronic devices to monitor the functional maturation of cardiomyocytes

Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first precisely understand on the cellular and molecular levels which factors are necessary for implanted stem-cell derived heart cells to properly grow and integrate in three dimensions within surrounding tissue.

8 Mar 2023

Breakthrough drug works against all the main types of primary bone cancer

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer.

8 Mar 2023

Preclinical News and Research

Using nanoparticles to encapsulate the medication may make corneal grafts more successful

What is the effect of maternal obesity on the brain development of offspring?

Gyros Protein Technologies introduces new PurePep EasyClean services to accelerate development and manufacturing of peptide-based drugs

Avanced genome editing technology could be used as a one-time treatment for CD3 delta SCID

Upgraded tumor model points the way toward more effective cancer therapies

New technique lights up cancerous tumors during surgery

Which exercises might reduce pro-inflammatory and enhance anti-inflammatory cytokines in older people with mild cognitive impairment or Alzheimer's disease?

Study provides strong support for AAV.NT-3 gene therapy in the management of sarcopenia

How does soy consumption affect the risk of type 2 diabetes and cardiovascular diseases?

Efficacy of a single dose of MVA-BN smallpox vaccine against Mpox

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

How does dietary intervention affect aging?

Long-term antibiotic therapy for adolescent acne can affect liver metabolism and promote adiposity

New genetic animal model may inform potential therapeutic options for Down syndrome

New tool allows researchers to perform genetic screens of cell-cell interactions

Study creates a radical new view of how immune cells recognize threats

New technique helps surgeons reconstruct more natural-looking nipples after mastectomy

Using tissue-embedded nanoelectronic devices to monitor the functional maturation of cardiomyocytes

Breakthrough drug works against all the main types of primary bone cancer

Event guide: 4th LNP Formulation & Process Development Summit eBook

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics