Aging News and Research

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Breakthrough in protein homeostasis offers potential for preventing Alzheimer’s

Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis (proteostasis), by which cells maintain the balance and proper functioning of their proteins.

3 Jan 2025

Addressing barriers to healthcare delivery for people with Alzheimer's disease and related dementias

Kosali Simon, PhD, M.A., a professor with the Paul H. O'Neill School of Public and Environmental Affairs and a Regenstrief Institute research scientist; and Katherine Baicker, PhD, University of Chicago provost, will co-lead an expected nearly $16 million National Institutes of Health's (NIH) National Institute on Aging (NIA) program to explore critical aspects of healthcare delivery for individuals living with Alzheimer's disease and related dementias (ADRD).

3 Jan 2025

Clue's CEO Rhiannon White on the Future of Femtech and PCOS

Under Rhiannon White's leadership, Clue is transforming menstrual health tracking into a powerful tool for research and improved reproductive health outcomes.

3 Jan 2025

Genetic mutation in esophageal cancer found to have dual effects

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer.

3 Jan 2025

Scientists uncover how aging rewires the brain's molecular landscape

Scientists mapped how aging alters gene expression across brain cell types in mice, revealing immune activation, neuronal decline, and hypothalamus-specific changes that may impact aging and neurodegeneration.

2 Jan 2025

Scientists launch public resource to classify cancer subtypes for better diagnosis

A multi-institutional team of scientists has developed a free, publicly accessible resource to aid in classification of patient tumor samples based on distinct molecular features identified by The Cancer Genome Atlas (TCGA) Network.

2 Jan 2025

Insilico Medicine nominates ISM1745 as preclinical candidate for MTAP-deleted cancers

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the nomination of ISM1745, a potentially best-in-class MTA cooperative PRMT5 inhibitor with AI-powered novel scaffold, as preclinical candidate (PCC) for the treatment of MTAP-deleted cancers.

2 Jan 2025

Researchers develop tool to measure biological age in individual cell types

A new priority research paper, featured as the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22, was published on December 29, 2024. The paper is titled "Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution."

2 Jan 2025

Histone markers predict human age with accuracy comparable to DNA methylation clocks

Researchers unveil histone-based age predictors, offering a new window into epigenetic aging and its shared patterns across tissues.

2 Jan 2025

Study reveals how fatty liver disease leads to liver cancer

Scientists at University of California San Diego School of Medicine have shed new light on the development of liver cancer, the sixth most frequently diagnosed cancer and fourth leading cause of cancer deaths worldwide.

2 Jan 2025

Brain mapping reveals cell-specific aging patterns

Based on new brain mapping research funded by the National Institutes of Health (NIH), scientists have discovered that not all cell types in the brain age in the same way.

1 Jan 2025

Machine learning reveals how metabolite profiles predict aging and health

Researchers developed metabolomic aging clocks using machine learning, uncovering links between metabolite profiles, health outcomes, and lifespan.

1 Jan 2025

Plant-based diets made easier for seniors with innovative tech

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1 Jan 2025

Lithocholic acid enhances health and lifespan, mimicking calorie restriction

Lithocholic acid (LCA), a metabolite induced by calorie restriction (CR), activates AMPK and mimics anti-aging benefits. A recent study highlights LCA's role in improving muscle performance, glucose tolerance, and lifespan in aged organisms.

1 Jan 2025

Rethinking the role of microbiome in age-related bone loss

Osteoporosis is a major health concern worldwide, particularly in aging populations. Despite pharmacological advancements, challenges like side effects, costs, and limited accessibility reduce adherence to treatments.

30 Dec 2024

Global study highlights Singapore's top ranking in aging society preparedness

Singapore has been ranked among the world's top 10 nations - and first in Asia - for its readiness to address the challenges and leverage the opportunities of an aging population, according to a recent study conducted by researchers from the National University of Singapore (NUS) and Columbia University.

27 Dec 2024