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Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

Groundbreaking genome-editing technique holds promise for treating Charcot–Marie–Tooth disease

Scientific advances in the last century have changed our world significantly. For example, the world of genetics has opened doors to a myriad of possibilities: augmented human capabilities, cures for diseases, and even changes to the course of evolution.

19 Dec 2023

Kyoto scientists map double whammy gene clusters for anxiety disorders

Anxiety disorders (ADs) affect more than 280 million people worldwide, making them one of the most common mental health conditions. ADs have a genetic basis as seen from inheritance in families, and people with one subtype of AD tend to have another subtype, suggesting a shared genetic basis.

19 Dec 2023

From Neanderthals to now: Tracing the evolution of human sleep cycles

Researchers examined the differences in circadian biology between the ancestors of modern humans and the archaic hominins such as Denisovans and Neanderthals and the contribution of archaic introgression in human chronotypes by using genomes to trace chronotype evolution from archaic hominins to modern-day humans.

19 Dec 2023

Shattering myths: Study reveals new insights on type 1 diabetes and obesity link

Review examines the relationship between type 1 diabetes and weight disorders, debunking myths about T1D and offering recommendations for future research and therapeutic interventions.

18 Dec 2023

Decoding the genome of world's biggest bacteria

Not all bacteria are created equal. Most are single-celled and tiny, a few ten-thousandths of a centimeter long. But bacteria of the Epulopiscium family are large enough to be seen with the naked eye and 1 million times the volume of their better-known cousins, E. coli.

18 Dec 2023

Scientists identify genetic and epigenetic culprits behind bilateral Wilms tumor

Children with bilateral Wilms tumor have a tumor in each of their kidneys - a condition that strongly suggests an underlying genetic or epigenetic predisposition driving the disease.

18 Dec 2023

Chia genome sequenced, revealing potential health benefits

In a recent study published in Frontiers in Plant Science, researchers presented the assembly of the chia reference genome.

18 Dec 2023

Spatial and subtype-specific regulation of ribosomal RNA genes in Arabidopsis revealed

Arabidopsis thaliana is a species grown worldwide for genetic research and was the first plant to have its complete set of chromosomes (its genome) sequenced.

15 Dec 2023

Waseda researchers unravel secrets of building better brain organoids with blood vessels

Researchers at Waseda University led by Assistant Professor Kosuke Kataoka, have uncovered crucial insights into brain organoids’ development.

15 Dec 2023

Study uncovers vast genomic diversity in Aboriginal Australian communities

Study on Aboriginal Australian communities using whole-genome sequencing reveals a high level of unique genetic diversity, including novel alleles and structural variants, crucial for understanding human genomic evolution and medical genetics.

14 Dec 2023

Research shows how the immune system keeps Herpes simplex virus at bay

Herpes simplex virus (HSV) is extremely common, affecting nearly two-thirds of the world's population, according to the World Health Organization.

14 Dec 2023

Fetal hormone GDF15 linked to nausea and vomiting in pregnancy

Study finds that high levels of the fetal hormone GDF15 in mothers are linked to an increased risk of nausea, vomiting, and hyperemesis gravidarum in pregnancy, offering new insights into the condition's etiology.

14 Dec 2023

Researchers develop a framework to identify potentially hidden genetic contributors to disease

Genome-wide association studies (GWAS) on patient blood samples are useful for identifying the genetic basis of blood cell traits and their links to common diseases.

14 Dec 2023

Study uncovers unique genetic diversity in Australian Indigenous populations

Scientists at ANU have revealed significant genetic diversity among Australian Indigenous communities, uncovering unique genetic variations that could impact personalized medical treatments for chronic diseases.

14 Dec 2023

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

A multidisciplinary study published in Nature has elucidated the structure of the machinery responsible for writing much of our "dark genome" - the 98 percent of our DNA that has largely unknown biological function.

14 Dec 2023

Novel machine learning tool predicts gain- and loss-of-function variants across the genome

In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across the genome.

14 Dec 2023

Association of genetically proxied PDE5 inhibition with measures of fertility, sexual behavior, and wellbeing

Researchers performed a two-sample Mendelian randomization analysis to investigate the associations between genetically proxied suppression of PDE5, a recognized pharmacological target for erectile dysfunction, fertility, subjective wellness, and sexual behavior.

14 Dec 2023

CRISPR opens doors for novel probiotic functions and applications

Humans can benefit significantly from symbiotic relationships with probiotics - live bacteria and microorganisms that influence the gut microbiota.

13 Dec 2023

Scientists unlock secret to repairing malnourished children's guts

A clinical trial reported in 2021 and conducted by a team of researchers from Washington University School of Medicine in St. Louis and the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh, showed that a newly designed therapeutic food aimed at repairing malnourished children's underdeveloped gut microbiomes was superior to a widely used standard therapeutic food.

13 Dec 2023

Genome News and Research

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Groundbreaking genome-editing technique holds promise for treating Charcot–Marie–Tooth disease

Kyoto scientists map double whammy gene clusters for anxiety disorders

From Neanderthals to now: Tracing the evolution of human sleep cycles

Shattering myths: Study reveals new insights on type 1 diabetes and obesity link

Decoding the genome of world's biggest bacteria

Scientists identify genetic and epigenetic culprits behind bilateral Wilms tumor

Chia genome sequenced, revealing potential health benefits

Spatial and subtype-specific regulation of ribosomal RNA genes in Arabidopsis revealed

Waseda researchers unravel secrets of building better brain organoids with blood vessels

Study uncovers vast genomic diversity in Aboriginal Australian communities

Research shows how the immune system keeps Herpes simplex virus at bay

Fetal hormone GDF15 linked to nausea and vomiting in pregnancy

Researchers develop a framework to identify potentially hidden genetic contributors to disease

Study uncovers unique genetic diversity in Australian Indigenous populations

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

Novel machine learning tool predicts gain- and loss-of-function variants across the genome

Association of genetically proxied PDE5 inhibition with measures of fertility, sexual behavior, and wellbeing

CRISPR opens doors for novel probiotic functions and applications

Scientists unlock secret to repairing malnourished children's guts

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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