Mutation News and Research

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Little-known protein found to play a role in common neurodegenerative disorder

Scientists have known for years that amyloid fibrils - fibrous, ropelike structures formed by closely linked protein molecules - are present in the brains of patients with Alzheimer's and Parkinson's diseases and likely play a role in the progression of these disorders.

20 Apr 2022

Mutated gene found in breast cancer recurrences may help tumors to become more aggressive

A mutated gene found in more than 20% to 30% of breast cancer recurrences may help tumors become more aggressive and promote metastasis, according to a pair of new studies that uncover mechanisms behind these processes and point to new therapy targets.

20 Apr 2022

Researchers reveal possible way to treat newborns with rare genetic lung condition

When babies are born with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), their skin starts to turn blue from the under-oxygenated blood in their systems.

19 Apr 2022

Researchers investigate Zika virus and Dengue virus co-immunity

In a new study, researchers successfully created new strains of the Zika virus and proved that the process of passaging through mice resulted in significantly increased virulence.

19 Apr 2022

New, longest documented case of persistent acute SARS-CoV-2 infection

Researchers describe a 16-month-old case of SARS-CoV-2 infection in an immunocompromised individual.

18 Apr 2022

New research on immune correlates for Janssen Ad26.Cov2.S COVID vaccine

ENSEMBLE data was used to evaluate three immune markers as correlates of protection following a single dose of Ad26.COV2.S vaccine.

18 Apr 2022

Research shines light on the effects of genomic variation on gut microbiome function

New research from Cornell scientists is exploring how human genetics impacts functions of the gut microbiome, and is expanding awareness of the role human genetics plays in shaping the microbiome.

18 Apr 2022

Mutation-acquiring potential of coronaviruses and efficacies of current COVID-19 vaccines against parent and mutant strains of SARS-CoV-2

Researchers reviewed the antibody resistance exhibited by SARS-CoV-2 variants.

18 Apr 2022

Yale research demonstrates the cancer relevance of known human genes

Following an analysis of over 12,000 human genes, research from Yale Cancer Center indicates there is cancer-relevant importance in a much larger proportion of human genes than current cancer research models suggest.

14 Apr 2022

New data-driven mechanistic approach can help reduce drug costs and treat diseases

A new data-driven mechanistic approach that predicts cell types within tissue will help to reduce drug costs and treat diseases that were difficult to develop drugs for, according to a West Virginia University scientist.

14 Apr 2022

Study explores role of APOBEC-mediated RNA editing in SARS-CoV-2 fitness

A new study investigated whether APOBEC proteins can directly edit the RNA sequence of SARS-CoV-2 to generate C-to-U mutations.

14 Apr 2022

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases, providing insights on RTK-RTK interactions and substrates, RTK-protein complexes, and signaling pathways.

13 Apr 2022

Epigenetics likely to be the reason why lung cancer patients develop treatment resistance

Doctors typically treat people with nonsmall cell lung cancer, a prevalent and typically incurable type of cancer that makes up 80%-85% of lung cancers, with tyrosine kinase inhibitors, specifically epidermal growth factor receptor inhibitors.

13 Apr 2022

Zika virus can mutate to become more infective and dangerous, finds study

LA JOLLA, CA - Researchers at La Jolla Institute for Immunology (LJI) have found that Zika virus can mutate to become more infective - and potentially break through pre-existing immunity.

13 Apr 2022

New bioinformatics platform predicts optimal treatment combinations for cancer patients

Researchers at The University of Texas MD Anderson Cancer Center have developed a new bioinformatics platform that predicts optimal treatment combinations for a given group of patients based on co-occurring tumor alterations.

12 Apr 2022

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Researchers identified mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoproteins (NP) epitope flanking regions and their potential effects on CD8+ T cell activation.

12 Apr 2022

Therapies for LGL leukemia should target the immune system, not only cancer cells

An international study coordinated by a University of Helsinki research group demonstrates that the body's immune system attacks itself in a rare type of blood cancer.

11 Apr 2022

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers - ATR inhibitor elimusertib and PARP inhibitor AZD5305 - are safe and clinically beneficial in treating patients with advanced solid tumors.

11 Apr 2022

Evidence of an increased risk of neurodegeneration after SARS-CoV-2 infection

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11 Apr 2022

Nanocell COVID-19 vaccine elicits potent neutralizing response

A new study describes the high level of neutralizing antibodies elicited by a nanocell vaccine against SARS-CoV-2 in vitro, in vivo, and human studies.

11 Apr 2022

Mutation News and Research

Little-known protein found to play a role in common neurodegenerative disorder

Mutated gene found in breast cancer recurrences may help tumors to become more aggressive

Researchers reveal possible way to treat newborns with rare genetic lung condition

Researchers investigate Zika virus and Dengue virus co-immunity

New, longest documented case of persistent acute SARS-CoV-2 infection

New research on immune correlates for Janssen Ad26.Cov2.S COVID vaccine

Research shines light on the effects of genomic variation on gut microbiome function

Mutation-acquiring potential of coronaviruses and efficacies of current COVID-19 vaccines against parent and mutant strains of SARS-CoV-2

Yale research demonstrates the cancer relevance of known human genes

New data-driven mechanistic approach can help reduce drug costs and treat diseases

Study explores role of APOBEC-mediated RNA editing in SARS-CoV-2 fitness

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

Epigenetics likely to be the reason why lung cancer patients develop treatment resistance

Zika virus can mutate to become more infective and dangerous, finds study

New bioinformatics platform predicts optimal treatment combinations for cancer patients

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Therapies for LGL leukemia should target the immune system, not only cancer cells

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Evidence of an increased risk of neurodegeneration after SARS-CoV-2 infection

Nanocell COVID-19 vaccine elicits potent neutralizing response

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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