Oxidative Stress News and Research

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Oxidative Stress is a condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma.

Children with autism experience deficits in immune cell that protects against infection

Children with autism experience deficits in a type of immune cell that protects the body from infection. Called granulocytes, the cells exhibit one-third the capacity to fight infection and protect the body from invasion compared with the same cells in children who are developing normally.

9 May 2014

RAAV/ABAD-DP-6His generates fusion peptide that protects PC12 cells from oxidative stress injury

The effects of Amyloid beta (Aβ)-Aβ-binding alcohol dehydrogenase (ABAD) may exacerbate Alzheimer's disease pathology.

8 May 2014

Discovery offers potential target for reversing progression of end-stage liver disease

A team of researchers in the University of Arizona's College of Pharmacy has discovered a molecular pathway that could be key to creating new therapeutics that would slow or even reverse the progression of end-stage liver disease.

26 Apr 2014

Noval neuroimaging technique enables detailed insights into mitochondria

Reactive oxygen species are important intracellular signaling molecules, but their mode of action is complex: In low concentrations they regulate key aspects of cellular function and behavior, while at high concentrations they can cause "oxidative stress", which damages organelles, membranes and DNA.

25 Apr 2014

Scientists examine Gpr109a receptor to find potential treatment for diabetic retinopathy

Like a daily pill to lower cholesterol can reduce heart attack and stroke risk, an easy-to-use agent that reduces eye inflammation could help save the vision of diabetics, scientists say.

22 Apr 2014

Highly advanced imaging method helps to monitor rapid changes in glutathione redox potentials in live cells

In the April issue of Experimental Biology and Medicine a multidisciplinary research team led by Drs. Rex Gaskins and Paul Kenis in the Institute of Genomic Biology (IGB) on the campus of the University of Illinois Urbana-Champaign describe their recent work on subcellular redox homeostasis.

21 Apr 2014

Angelica sinensis polysaccharides alleviate neuronal cell injury caused by oxidative stress

According to traditional Chinese medicine, the roles of Angelica sinensis correlate with tonifying the blood and promoting its circulation. Recent studies have shown that extracts of Angelica sinensis have antioxidative and neuroprotective effects.

10 Apr 2014

Professor receives $1.7M NIH grant to explore novel treatments for chronic methamphetamine users

A Wayne State University professor recently received a nearly $1.7 million grant from the National Institutes of Drug Abuse of the National Institutes of Health to explore whether proteasome and parkin — two components of the ubiquitin-proteasome system — are potential pharmaceutical drug targets that can be manipulated to promote survival and recovery of dopaminergic terminals after binge and chronic administration of toxic doses of methamphetamine.

8 Apr 2014

Study describes two new genes that influence risk of women developing breast, ovarian cancer

Today we know that women carrying BCRA1 and BCRA2 gene mutations have a 43% to 88% risk of developing from breast cancer before the age of 70.

7 Apr 2014

Thorne Research launches NiaCel that supports endurance, energy and healthy aging

Thorne Research today announced the launch of NiaCel™, an innovative nutritional supplement that supports endurance, energy, and healthy aging.

2 Apr 2014

Young adults with cardiac risk factors have worse cognitive function in middle age

Young adults with such cardiac risk factors as high blood pressure and elevated glucose levels have significantly worse cognitive function in middle age, according to a new study by dementia researchers at UC San Francisco.

1 Apr 2014

NeuroVive Pharmaceutical initiates research collaboration with A1M Pharma

NeuroVive Pharmaceutical AB (publ) and A1M Pharma AB (publ) have announced that the two companies are initiating a research collaboration in mitochondrial medicine. The partnership is governed by a collaboration agreement signed on 21 March 2014.

25 Mar 2014

Body clock's could be utilized to improve current therapies to delay onset of chronic lung diseases

The body clock's natural rhythm could be utilized to improve current therapies to delay the onset of chronic lung diseases.

From The University of Manchester 18 Mar 2014

Edison Pharmaceuticals begins EPI-743 clinical trial in children with Pearson syndrome

Edison Pharmaceuticals today announced the initiation of a phase 2 study entitled "A Phase 2 Safety and Efficacy Study of EPI-743 (Vincerinone™) in Children with Pearson Syndrome." The Investigative New Drug application (IND) was approved by the Food and Drug Administration, Office of Hematology and Oncology Products.

17 Mar 2014

FDA grants Fast Track designation to Edison’s lead drug EPI-743

Edison Pharmaceuticals today announced that the United States Food and Drug Administration granted Fast Track designation to EPI-743, the company's lead drug, for the treatment of Friedreich's ataxia. EPI-743 is being developed for pediatric and adult mitochondrial disease, including Friedreich's ataxia.

17 Mar 2014

Study provides insight into the mechanisms underlying diabetic peripheral neuropathy

Iron overload can lead to cytotoxicity, and it is a risk factor for diabetic peripheral neuropathy. However, the underlying mechanism remains unclear.

13 Mar 2014

Researchers examine role of alpha-synuclein in neuronal cells

Alpha-synuclein is a principal component of Lewy bodies and Lewy neurites, which are pathologic hall-marks of Parkinson's disease. Alpha-synuclein is generally considered to play a role in synaptic activity, although its function remains largely unknown.

13 Mar 2014

Oxidative Stress News and Research

Further Reading

Children with autism experience deficits in immune cell that protects against infection

RAAV/ABAD-DP-6His generates fusion peptide that protects PC12 cells from oxidative stress injury

Discovery offers potential target for reversing progression of end-stage liver disease

Noval neuroimaging technique enables detailed insights into mitochondria

Scientists examine Gpr109a receptor to find potential treatment for diabetic retinopathy

Highly advanced imaging method helps to monitor rapid changes in glutathione redox potentials in live cells

Angelica sinensis polysaccharides alleviate neuronal cell injury caused by oxidative stress

Professor receives $1.7M NIH grant to explore novel treatments for chronic methamphetamine users

Study describes two new genes that influence risk of women developing breast, ovarian cancer

Thorne Research launches NiaCel that supports endurance, energy and healthy aging

Young adults with cardiac risk factors have worse cognitive function in middle age

NeuroVive Pharmaceutical initiates research collaboration with A1M Pharma

Body clock's could be utilized to improve current therapies to delay onset of chronic lung diseases

Edison Pharmaceuticals begins EPI-743 clinical trial in children with Pearson syndrome

FDA grants Fast Track designation to Edison’s lead drug EPI-743

Study provides insight into the mechanisms underlying diabetic peripheral neuropathy

Researchers examine role of alpha-synuclein in neuronal cells

Gene linked with breast cancer susceptibility plays critical role in obesity and diabetes

Aged mice lacking antioxidant protein Nrf2 show poor stem cell regeneration

Edison Pharmaceuticals initiates Phase 2B/3 study of EPI-743 in children with Leigh syndrome

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Evaluating new approaches for rare disease genomics

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Advancing Intracellular Delivery with LumiPore®

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