Clinical Trial News and Research

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Ardea Biosciences completes phase 1 trials of HIV drug RDEA806

Ardea Biosciences, Inc. has announced that it has successfully completed Phase 1 single-ascending-dose, multiple-ascending-dose, food-effect, and drug-interaction studies of RDEA806, a novel HIV non-nucleoside reverse transcriptase inhibitor (NNRTI), in healthy volunteers.

5 Sep 2007

New phages to treat bacterial diseases

Viruses found in the River Cam in Cambridge, famous as a haunt of students in their punts on long, lazy summer days, could become the next generation of antibiotics, according to scientists speaking today (Monday 3 September 2007) at the Society for General Microbiology's 161st Meeting at the University of Edinburgh, UK, which runs from 3-6 September 2007.

3 Sep 2007

Abbott and AstraZeneca confirm Phase III clinical trials of Fenofibrate ABT-335 and Crestor as fixed-dose combination

Abbott and AstraZeneca confirmed they will advance the development of Abbott's next-generation fenofibrate ABT-335 and AstraZeneca's CRESTOR (rosuvastatin calcium) in a fixed-dose combination treatment into Phase III clinical trials.

3 Sep 2007

Immediate emergency angioplasty can save the lives of those experiencing MI

We have demonstrated that patients who have an acute myocardial infarction and are admitted to a hospital which has no possibility to perform direct angioplasty, benefit from being transferred immediately after having received thrombolytics to a hospital where angioplasty (percutaneous coronary intervention, PCI, often including stent implantation) can be immediately performed.

3 Sep 2007

Efficacy of non-invasive ventilation in patients with acute cardiogenic pulmonary oede

Acute cardiogenic pulmonary oedema, or "fluid on the lung", is a common, extremely distressing and often fatal condition that is a major consumer of health care resources. The aim of the 3CPO trial was to establish whether high-pressure oxygen, given by a simple facemask, could help reduce the death rate in patients with this condition.

2 Sep 2007

Survey to evaluate arrhythmia rate in so-called high-risk MI patients

Sudden cardiac death is the leading cause of mortality in European and North-American countries. Studies have been attempting to identify the right population of patients at high risk of Sudden Cardiac Death ever since the introduction of the Implantable Cardioverter Defibrillators (ICD).

2 Sep 2007

Inhaling nitric oxide helps transplant success

Administering inhaled nitric oxide (NO) during surgery helps protect liver transplant patients from organ failure, according to a new study from researchers at the University of Alabama at Birmingham (UAB).

30 Aug 2007

Flaxseed for hot flashes

Data from a new Mayo Clinic study suggest that dietary therapy using flaxseed can decrease hot flashes in postmenopausal women who do not take estrogen.

30 Aug 2007

New generation of implanted heart-assisting pumps help patients survive, regain function til transplant

A new generation of implanted heart-assisting pump does very well at helping severely ill heart-failure patients survive, and thrive, until they receive a heart transplant, a new study shows.

30 Aug 2007

Fingolimod shows promise in 2 lethal leukemias

A new study suggests that an experimental drug being tested for the treatment of multiple sclerosis and to prevent organ rejection might also help people with certain deadly forms of chronic and acute leukemia.

29 Aug 2007

'Mighty mice' made mightier

The Johns Hopkins scientist who first showed that the absence of the protein myostatin leads to oversized muscles in mice and men has now found a second protein, follistatin, whose overproduction in mice lacking myostatin doubles the muscle-building effect.

29 Aug 2007

Hypnosis before breast cancer surgery shows benefits

The use of hypnosis prior to breast cancer surgery reduced the amount of anesthesia administered during the operation, the level of pain reported afterwards, and the time and cost of the procedure, according to a study published online August 28 in the Journal of the National Cancer Institute .

29 Aug 2007

FDA approves new Roche direct detection of West Nile Virus in donated human blood

Roche Diagnostics announced that the US Food & Drug Administration (FDA) has approved its biologics license application for the company's test for direct detection of West Nile Virus in donated human blood and plasma.

From Roche Sequencing and Life Science 29 Aug 2007

FDA approves Evithrom (human thrombin)

The U.S. Food and Drug Administration has approved Evithrom (human thrombin), a blood-clotting protein used to help control bleeding during surgery.

28 Aug 2007

IDM Pharma receives not approvable letter for Mifamurtide for treatment of osteosarcoma

IDM Pharma, Inc. ( NASDAQ:IDMI ) announced today that it received a not approvable letter from the U.S. Food and Drug Administration (FDA) after completing the review of the new drug application (NDA) for the investigational drug mifamurtide (L-MTP-PE), formerly known as Junovan, for the treatment of non-metastatic osteosarcoma, a rare and often fatal bone tumor that typically affects children and young adults.

28 Aug 2007

Oglufanide disodium in new hepatitis C trial

Physicians at Southern Health have started a phase IIa clinical trial designed to test the efficacy of a new strategy for defeating hepatitis C viral infection, one of the toughest infectious diseases in the modern world.

26 Aug 2007

Study looks at salsalate for type 2 diabetes

The University of Illinois at Chicago is one of 16 sites in the United States taking part in the first large-scale study to test a promising approach to lowering blood glucose levels in adults with type 2 diabetes.

24 Aug 2007

Reported failure of vitamin E to prevent heart attacks may be due to underdosing

The findings, published early online in Free Radical Biology and Medicine, suggest that these earlier studies all had a fundamental flaw the doses used werent high enough to have a significant antioxidant effect.

24 Aug 2007

Study looks at large burns

Large burns can trigger cardiac problems and enhanced inflammatory and hypermetabolic responses in patients, a study in the online open access journal Critical Care suggests.

24 Aug 2007

Surgical options for severe intra-abdominal inflammation

Performing a repeat surgery for patients with peritonitis (severe intra-abdominal inflammation or infection) only when clinical improvement is lacking may have some advantages compared with having the repeat procedure routinely scheduled after the operation, according to a study in the August 22/29 issue of JAMA.

22 Aug 2007

Clinical Trial News and Research

Ardea Biosciences completes phase 1 trials of HIV drug RDEA806

New phages to treat bacterial diseases

Abbott and AstraZeneca confirm Phase III clinical trials of Fenofibrate ABT-335 and Crestor as fixed-dose combination

Immediate emergency angioplasty can save the lives of those experiencing MI

Efficacy of non-invasive ventilation in patients with acute cardiogenic pulmonary oede

Survey to evaluate arrhythmia rate in so-called high-risk MI patients

Inhaling nitric oxide helps transplant success

Flaxseed for hot flashes

New generation of implanted heart-assisting pumps help patients survive, regain function til transplant

Fingolimod shows promise in 2 lethal leukemias

'Mighty mice' made mightier

Hypnosis before breast cancer surgery shows benefits

FDA approves new Roche direct detection of West Nile Virus in donated human blood

FDA approves Evithrom (human thrombin)

IDM Pharma receives not approvable letter for Mifamurtide for treatment of osteosarcoma

Oglufanide disodium in new hepatitis C trial

Study looks at salsalate for type 2 diabetes

Reported failure of vitamin E to prevent heart attacks may be due to underdosing

Study looks at large burns

Surgical options for severe intra-abdominal inflammation

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