Clinical Trial News and Research

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Study of VentrAssist heart support device as a bridge to transplantation

Doctors at UPMC have begun a study using an investigational cardiac device, the VentrAssist, Left Ventricular Assist System (LVAD) to see whether it can be used safely and effectively in patients with end-stage heart failure.

23 May 2007

Combination of medicines best for blood pressure control

Millions of Americans take medications for hypertension but do not achieve control of their blood pressure.

22 May 2007

Surgeries to treat urinary incontinence in women

The University of California, San Diego Medical Center along with nine other clinical research institutions across the United States has completed the largest randomized clinical trial to date comparing two commonly performed surgical procedures to treat urinary stress incontinence.

22 May 2007

New data on natural probiotic bacterial strain of Bifantis shows anti-inflammatory properties

The biotechnology company Alimentary Health today announced results from two studies that demonstrate the anti-inflammatory activity of a natural probiotic bacterial strain of human origin, Bifantis (Bifidobacterium infantis 35624), in models of arthritis and Salmonella infection.

22 May 2007

Muscle stem cells treat urinary incontinence

Women with stress urinary incontinence (SUI) treated using muscle-derived stem cell injections to strengthen their sphincter muscles experience long-term improvements in their condition, according to a study led by researchers at the University of Pittsburgh School of Medicine and Sunnybrook Health Sciences Centre in Toronto.

22 May 2007

GSK strongly disagrees with conclusions reached in NEJM article on Avandia

GlaxoSmithKline has issued the following response to an article in the New England Journal of Medicine (NEJM) on Avandia (rosiglitazone maleate), a widely used and highly effective treatment for type 2 diabetes.

22 May 2007

Clinical trial data for Perforomist Inhalation solution

Data presented at the International Conference of the American Thoracic Society (ATS) demonstrate that Perforomist (formoterol fumarate) Inhalation Solution, delivered by nebulization, is an effective and well-tolerated new treatment option for patients suffering from emphysema or chronic bronchitis, otherwise known as Chronic Obstructive Pulmonary Disease (COPD).

22 May 2007

The Medical Research Council welcomes FSA decision to add folic acid to flour

The Medical Research Council (MRC) has welcomed the Food Standards Agency’s (FSA) decision to recommend the mandatory fortification of flour with folic acid.

20 May 2007

Large trial to identify the long-term health effects of West Nile virus infection

UT Southwestern Medical Center has joined a national clinical trial to identify the long-term health effects of West Nile virus infection and to learn more about the disease's progression, symptoms and mortality.

18 May 2007

Peregrine Pharmaceuticals to initiate new Bavituximab HCV trial

Peregrine Pharmaceuticals has announced it has filed a new clinical trial protocol with the FDA to study bavituximab in patients co-infected with HCV and the human immunodeficiency virus (HIV).

18 May 2007

Celecoxib offers promise for premature babies

Scientists have found evidence that the cox-2 inhibitor celecoxib, a common pain reliever used to treat arthritis, may offer a new way to reduce the risk of the most common cause of brain damage in babies born prematurely.

18 May 2007

Some NSAIDs may be better suited to treating cancer

Until recently, nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and celecoxib (sold as Celebrex), were being hailed as promising cancer prevention drugs.

18 May 2007

Albuterol may help kids with bronchiolitis

Bronchiolitis, a wheezing much like asthma in adults, is responsible for many hospital admissions of infants.

17 May 2007

Testosterone gel helps men multiple sclerosis

Close on the heels of a large-scale clinical trial just underway to confirm that the female hormone estriol combats the effects of multiple sclerosis (MS) in women, a just completed pilot study at UCLA now shows promise for the use of testosterone to combat its effects in men.

16 May 2007

Reducing cardiovascular disease risk factors when discontinuing HRT

Hormone replacement therapy (HRT) has been shown to reduce many cardiovascular disease (CVD) risk factors, but many women have stopped using HRT due to reports from the Women's Health Initiative that HRT may increase the risk of breast cancer and heart disease.

16 May 2007

Multiple myeloma dexamethasone / lenalidomide trial closes

The Southwest Oncology Group, the largest of several National Cancer Institute-sponsored clinical trials networks, has permanently closed enrollment in a trial comparing a standard drug therapy, dexamethasone, with a combined therapy of the same drug plus the drug lenalidomide (Revlimid) for people newly diagnosed with multiple myeloma.

16 May 2007

FDA approves Dey, L.P.'s NDA for chronic obstructive pulmonary disease inhalation solution

Dey, L.P. has announced that the Food and Drug Administration (FDA) has approved its New Drug Application (NDA) for Perforomist (formoterol fumarate) Inhalation Solution for long-term, twice-daily maintenance treatment of bronchoconstriction for emphysema and chronic bronchitis, also known as Chronic Obstructive Pulmonary Disease (COPD).

15 May 2007

Role of PCI and coronary artery bypass grafting for the treatment of patients with left main coronary artery disease

Coronary artery bypass surgery has been the preferred treatment for patients with a blockage in the left main coronary artery, the conduit that supplies blood to about two-thirds of the heart.

15 May 2007

Coenzyme Q10 does not improve Parkinson's disease symptoms

Small doses of the antioxidant coenzyme Q10 appear to increase blood levels of this naturally occurring compound in patients with Parkinson's disease, but does not improve Parkinson's disease symptoms, according to an article posted online today that will appear in the July 2007 print issue of Archives of Neurology, one of the JAMA/Archives journals.

15 May 2007

Calcium plus vitamin D may help prevent weight gain in postmenopausal women

Postmenopausal women who take calcium and vitamin D supplements may gain less weight than those who do not, although the overall effect is small, according to a report in the May 14 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

15 May 2007