Clinical Trial News and Research

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Little evidence multivitamins prevent chronic diseases

There is little scientific evidence to suggest that taking a multivitamin supplement helps Americans ward off chronic diseases, including most cancers and cardiovascular disease.

23 May 2006

Clinical trials funded by for-profit organizations more likely to report positive

Cardiovascular clinical trials published between 2000 and 2005 were significantly more likely to report positive findings if they were funded by for-profit organizations than those funded by not-for-profit organizations, according to a study in JAMA: The Journal of the American Medical Association.

23 May 2006

Nutritional supplement policosanol does not lower cholesterol levels

A new study suggests that use of the nutritional supplement policosanol does not lower cholesterol levels any more than placebo, apparently contradicting the results of previous studies.

23 May 2006

Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

A protein that activates estrogen receptors in breast cancer may play a role in resistance to therapeutic effects of anti-estrogen tamoxifen treatment, according to a study in the Journal of the National Cancer Institute.

17 May 2006

Effectiveness of radiation therapy for older women with early breast cancer

Elderly women with early-stage breast cancer had a lower risk of recurrence when they were treated with radiation therapy, according to a study in the Journal of the National Cancer Institute.

17 May 2006

New compound shows unique potency against cancer cell proliferation

By determining how a class of compounds blocks signaling in cells, University of California, San Francisco (UCSF) scientists have identified what is perhaps the most potent drug candidate yet against a highly lethal kind of brain tumor.

16 May 2006

Inhaled corticosteroids can reduce breathing problems in children at high risk for asthma

Studies in older children and adults show that the most effective long-term control medicine for persistent asthma (symptoms more than two days a week or more than twice a month at night) is inhaled corticosteroids, which reduce airway swelling and help prevent asthma symptoms (e.g., asthma attacks).

10 May 2006

Promising chemo, therapeutic viruses, cutting-edge surgery debut at M. D. Anderson Cancer Center

Brain tumor specialists at The University of Texas M. D. Anderson Cancer Center are poised on the brink of a new era.

10 May 2006

Long-term estrogen therapy may be related to a higher risk of breast cancer

Previous studies have linked the use of hormone therapy to breast cancer among postmenopausal women, but have primarily focused on the hormone combination of estrogen plus progestin, according to background information in the article.

9 May 2006

New approaches to genetic disease, based on cells' own ability to correct themselves

New approaches to genetic disease, based on cells' own ability to correct themselves, will be outlined today at the annual conference of the European Society of Human Genetics in Amsterdam, The Netherlands.

8 May 2006

Combined pharmacotherapies and behavioral interventions for alcohol dependence

While many treatment approaches were found helpful, the authors report that the patients who were most successful in abstaining from alcohol 16 weeks after treatment were those prescribed naltrexone under medical management and those participating in a multi-session program of alcohol counseling delivered by a behavioral specialist.

3 May 2006

Drug combo significantly more effective in reducing dyspepsia in arthritis patients

UCLA/VA researchers found that for arthritis patients, taking a combination of two drugs may be most effective in protecting against stomach upset called dyspepsia, which is a side effect of common pain medications.

3 May 2006

Peplin announces positive results of skin cancer trial

Peplin Limited today announced positive results from its Australian phase IIa clinical trial of its proprietary drug PEP005 Topical in superficial forms of basal cell carcinoma (sBCC) the most common form of skin cancer.

1 May 2006

Economic benefit of federally finded clinical trials exceeds $15 billion

A comprehensive review of all phase III clinical trials supported by one Federal agency finds that, estimated conservatively, the economic benefit in the United States from just eight of these trials exceeded $15 billion over the course of 10 years. The study also found that new discoveries from the trials were responsible for an estimated additional 470,000 healthy years of life. The clinical trials were sponsored by the National Institutes of Health's National Institute of Neurological Disorders and Stroke (NINDS).

28 Apr 2006

Economic benefit of federally finded clinical trials exceeds $15 billion

28 Apr 2006

Enzyme discovery could reduce Kaposi sarcoma tumour growth and lead to drugs suitable for treating other viral cancers

A report in the Journal of Biological Chemistry shows that inhibition of heme oxygenase-1, an enzyme involved in iron metabolism, reduces Kaposi sarcoma tumor growth. This discovery could result in the production of new drugs to treat this and other viral cancers.

28 Apr 2006

'Resonance' may be the reason for virologic failure in STI drug therapy

Researchers have been puzzled over why HIV-positive patients who have periodic, built in interruptions in their drug therapy reach a point where the therapy no longer reduces their viral loads, even in the absence of any evidence of acquired drug resistance.

25 Apr 2006

Clinical Trial News and Research

Little evidence multivitamins prevent chronic diseases

Clinical trials funded by for-profit organizations more likely to report positive

Nutritional supplement policosanol does not lower cholesterol levels

Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

Effectiveness of radiation therapy for older women with early breast cancer

New compound shows unique potency against cancer cell proliferation

Inhaled corticosteroids can reduce breathing problems in children at high risk for asthma

Promising chemo, therapeutic viruses, cutting-edge surgery debut at M. D. Anderson Cancer Center

Long-term estrogen therapy may be related to a higher risk of breast cancer

New approaches to genetic disease, based on cells' own ability to correct themselves

Combined pharmacotherapies and behavioral interventions for alcohol dependence

Drug combo significantly more effective in reducing dyspepsia in arthritis patients

Peplin announces positive results of skin cancer trial

Economic benefit of federally finded clinical trials exceeds $15 billion

Economic benefit of federally finded clinical trials exceeds $15 billion

Enzyme discovery could reduce Kaposi sarcoma tumour growth and lead to drugs suitable for treating other viral cancers

'Resonance' may be the reason for virologic failure in STI drug therapy

Corticosteroids do not improve survival in patients with late-stage acute respiratory distress syndrome

Study into whether folic acid and other B vitamins can help slow dementia

New orthostatic hypotension treatment reduces symptoms without causing high blood pressure

Event guide: 15th World Clinical Biomarkers & CDx Europe eBook

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The role of UV-Vis in biopharma QC

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