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Adult stem cell implant first in orthopaedic patient

The Royal Melbourne Hospital has performed the world's first implant of cultured specialist stem cells into an orthopaedic patient who suffered a broken femur nine months ago which failed to heal.

19 Apr 2006

Promising treatment for Huntington's disease soon to be tested clinically

At the Institut Curie, CNRS and Inserm researchers have shown that cysteamine, which is already used to treat a rare disease called cystinosis, prevents the death of neurons in Huntington's disease. Like Alzheimer's and Parkinson's, Huntington's disease, is characterized by the abnormal death of neurons.

19 Apr 2006

Prostate cancer research may be faster with prostate-specific antigen endpoints

A new study from Columbia University Medical Center researchers at NewYork-Presbyterian Hospital/Columbia, who are members of the Southwest Oncology Group (SWOG), suggests that certain changes in prostate-specific antigen (PSA) levels may serve as surrogate endpoints for prostate cancer survival.

18 Apr 2006

First gene therapy human trial in the United States for a form of muscular dystrophy under way

The clinical trial for Duchenne muscular dystrophy (DMD) tests the safety and effectiveness of a therapy that was developed over two decades by scientists at the University of North Carolina Chapel Hill's School of Medicine and the University of Pittsburgh.

16 Apr 2006

Doses of DNA-gene-coated gold particles protect against harmful protein implicated in Alzheimer's disease

Doses of DNA-gene-coated gold particles protect mice against a protein implicated in Alzheimer's disease, researchers at UT Southwestern Medical Center have found.

16 Apr 2006

Diabetes: Translating the chronic care model into the community

Educating people with diabetes in a primary-care setting with sustained, comprehensive intervention resulted in significant improvement in disease management and overall health, according to a study published in the current issue of Diabetes Care, a journal of the American Diabetes Association (ADA).

16 Apr 2006

Trial of low-dose Isotretinoin for prevention of second primary tumors in head and neck cancer patients

Taking a vitamin A derivative called isotretinoin did not reduce the risk of second primary tumors or improve survival in patients with stage I or II head and neck squamous cell cancers (HNSCC), according to a study in the Journal of the National Cancer Institute.

13 Apr 2006

No evidence that taking estrogen alone increases the risk of breast cancer in postmenopausal women

The findings come three years after a related WHI study found that a different type of hormone therapy - which combined estrogen and progestin - did result in a higher risk of breast cancer among postmenopausal women.

13 Apr 2006

Losartan can prevent progression of Marfan syndrome

A commonly prescribed blood pressure medication may provide the first ray of hope in preventing potentially deadly complications of Marfan syndrome, a genetic disease that weakens the structural meshwork of blood vessels.

11 Apr 2006

Evaluation of an inactivated subunit H5N1 influenza virus vaccine in humans

Results from a clinical trial demonstrate that high doses of an experimental H5N1 avian influenza vaccine can induce immune responses in healthy adults.

11 Apr 2006

Lack of response to herceptin may be reversed with PI3K inhibiting agents

Breast cancer patients with HER2-positive tumors who don't respond to Herceptin (trastuzumab) may benefit from cocktail therapy that includes Herceptin along with one or more PI3K inhibiting agents, say researchers at the University of Texas M. D. Anderson Cancer Center.

11 Apr 2006

A genomic signature of 254 genes predicting clinical outcome in Primary Cutaneous Melanoma identified

EORTC Melanoma Group researchers have identified a genomic signature predicting clinical outcome in Primary Cutaneous Melanoma, after patients having undergone standard treatment.

6 Apr 2006

Peptide for myocardial infarction proves to be safe

FIBREX Medical has successfully completed a first dose in man study with its lead product, the anti-inflammatory peptide FX06.

6 Apr 2006

Drug trial disaster will discourage future volunteers

According to the British government agency responsible for medical safety, the Medicines and Healthcare Products Regulatory Agency (MHRA), no evidence has been found to suggest there were any problems with the manufacturing of a drug which left six volunteers seriously ill.

6 Apr 2006

Vitamin C in the blood stream is directly related to fat oxidation

Nutrition researchers from Arizona State University report that the amount of vitamin C in the blood stream is directly related to fat oxidation - the body's ability to use fat as a fuel source - during both exercise and at rest.

6 Apr 2006

First artificial heart implant on the East Coast

A cardiac surgery team at Virginia Commonwealth University's Pauley Heart Center has performed the first artificial heart implant on the East Coast. The CardioWest temporary Total Artificial Heart, or TAH-t, is the only total artificial heart approved by the U.S. Food and Drug Administration.

6 Apr 2006

Ingredient in red peppers inhibits prostate cancer in laboratory studies

Capsaicin is the pungent ingredient in red peppers and is presently used as a topical pain reliever. Now, a new study shows it may be justified to evaluate capsaicin for inhibiting prostate cancer (CaP) in patients.

5 Apr 2006

Functional magnetic resonance imaging can predict effectiveness of cognitive behavior therapy for treating depression

Whether or not cognitive behavior therapy (CBT) will help a person recover from depression can be predicted through brain imaging, according to research results published by the University of Pittsburgh School of Medicine in the April issue of the American Journal of Psychiatry.

4 Apr 2006

Researchers reverse juvenile diabetes in animal model

Groundbreaking human clinical trial for type 1 diabetes to start this spring in Pittsburgh - Children's Hospital of Pittsburgh of UPMC researchers reverse juvenile diabetes in animal model; Phase 1 clinical trial approved by FDA.

4 Apr 2006

Link between lead and osteoporosis strengthens

Bolstered by recent laboratory findings, researchers at the University of Rochester Medical Center are embarking on a National Institutes of Health-funded clinical study to better understand the deceptive role environmental lead exposure plays in bone maturation and loss.

4 Apr 2006