Mutation News and Research

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The evolution of the SARS-CoV-2 spike protein

Researchers discuss the evolution and mechanisms of mutations that have occurred in the spike protein of SARS-CoV-2.

31 Mar 2022

Study estimates the comparative abundance of SARS-CoV-2 variants via wastewater monitoring

A recent study estimated the comparative abundance of SARS-CoV-2 variants via wastewater monitoring.

31 Mar 2022

MERS-CoV-related viruses invade host cells via bat angiotensin-converting enzyme 2 receptors

A recent study discovered that near relatives of MERS-CoV utilize ACE2 as functional receptors.

31 Mar 2022

Messenger ribonucleic acid boosters shown to be effective against Omicron infections in mice

Researchers evaluated the protection conferred by booster doses of the preclinical version of the Moderna mRNA-1273 vaccine and a SARS-CoV-2 Omicron variant-matched vaccine against Omicron infections in mice.

31 Mar 2022

Study identifies a set of sporadic genetic mutations behind cavernous angioma

A rare type of brain blood vessel malformation known as a cavernous angioma affects more than one million Americans and carries a lifetime risk of stroke and seizures.

30 Mar 2022

Chemical in leafy greens could prevent infections by coronaviruses including SARS-CoV-2

Researchers discuss the use of the isothiocyanate sulforaphane for the treatment of both SARS-CoV-2 and HCoV-OC43 infections.

30 Mar 2022

New tactic to disrupt cancer repair mechanism could lead to a potential treatment strategy

While cancer therapies targeting specific genes or disease pathways have extended lives, they can also lead to highly resistant tumors when small reservoirs of cancer cells survive treatment, grow, and spread.

30 Mar 2022

Study analyzed several naturally-occurring amino acid variations found in the extended loop harboring the SARS-CoV-2 S1/S2 cleavage site

A recent study analyzed the polymorphisms in the SARS-CoV-2 spike proteins' S1/S2 subunits.

30 Mar 2022

Study investigates whether coinfection with multiple SARS-CoV-2 variants exists in COVID-19 patients

A new study shows that multiple variants of this virus may coinfect the same patient, using both genomic sequencing data and computational models.

30 Mar 2022

SARS-CoV-2 nucleocapsid protein linked to COVID-19 severity

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes respiratory coronavirus disease 2019 (COVID-19) triggered an unprecedented public health emergency. Human mobility patterns were fundamental to the spread of SARS-CoV-2 globally. The situation is particularly acute in a country like Saudi Arabia, which has seen more than 750,000 cases and over 9,000 deaths as of March 30th, 2022.

29 Mar 2022

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

Furin inhibitors as potential therapeutics for treating COVID-19 and other diseases, wherein furin is integral for their pathogenicity and progression.

29 Mar 2022

A bioinformatics approach for detecting SARS-CoV-2 co-infections

Researchers discuss a novel bioinformatics-based method for the detection of SARS-CoV-2 co-infections with the Delta and Omicron variants.

29 Mar 2022

$4 million program launched to find transformative therapies for ADNP syndrome

Researchers at the UC Davis MIND Institute are launching a $4 million program to find transformative therapies for ADNP syndrome. The rare genetic condition causes developmental delays and can affect the brain, heart, gastrointestinal system and more.

29 Mar 2022

Study tracks the rapid shift from Omicron BA.1 to BA.2 sub-variant dominance in Sweden

Researchers tracked the rapid shift from the new SARS-CoV-2 VOC Omicron BA.1 sub-variant dominance to BA.2 sub-variant dominance in Sweden between January and March 2022.

29 Mar 2022

Northwestern scientists continue to advance the understanding of COVID-19

As the COVID-19 pandemic enters its third year, Northwestern Medicine scientists continue to help advance the understanding of the disease and its impact, from investigating antibody protection against COVID-19 reinfection to elevating women in academic research and highlighting racial and ethnic disparities in COVID-19 hospital mortality in Illinois.

28 Mar 2022

Study investigates recombinant SARS-CoV-2 variants in immunocompromised individuals

Researchers identified the recombination of two SARS-CoV-2 variants.

28 Mar 2022

Biologists discover gene deletion behind abnormality in blood cancer cells

The mystery is being unraveled of why the control centers, or nuclei, of certain blood cancer cells have a distinctly odd shape.

27 Mar 2022

HIV patients on antiretroviral treatment with protease inhibitors may have lower COVID-19 risk

A preliminary study to be presented at this year's European Congress of Clinical Microbiology & Infectious Diseases in Lisbon, Portugal (23-26 April), suggests that people living with HIV who are on antiretroviral treatment (ART) with protease inhibitors (PI), may have a lower risk of COVID-19 infection.

27 Mar 2022

Researchers show how an important inhibitor binds to the A2A receptor

The A2A receptor regulates how vigorously the innate immune system attacks diseased cells.

25 Mar 2022

Study finds methylene blue is a low-micromolar inhibitor of the the SARS-CoV-2 spike protein and ACE2 interaction

A new study has focussed on screening and identification of possible SMIs of this PPI for COVID-19.

25 Mar 2022

Mutation News and Research

The evolution of the SARS-CoV-2 spike protein

Study estimates the comparative abundance of SARS-CoV-2 variants via wastewater monitoring

MERS-CoV-related viruses invade host cells via bat angiotensin-converting enzyme 2 receptors

Messenger ribonucleic acid boosters shown to be effective against Omicron infections in mice

Study identifies a set of sporadic genetic mutations behind cavernous angioma

Chemical in leafy greens could prevent infections by coronaviruses including SARS-CoV-2

New tactic to disrupt cancer repair mechanism could lead to a potential treatment strategy

Study analyzed several naturally-occurring amino acid variations found in the extended loop harboring the SARS-CoV-2 S1/S2 cleavage site

Study investigates whether coinfection with multiple SARS-CoV-2 variants exists in COVID-19 patients

SARS-CoV-2 nucleocapsid protein linked to COVID-19 severity

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

A bioinformatics approach for detecting SARS-CoV-2 co-infections

$4 million program launched to find transformative therapies for ADNP syndrome

Study tracks the rapid shift from Omicron BA.1 to BA.2 sub-variant dominance in Sweden

Northwestern scientists continue to advance the understanding of COVID-19

Study investigates recombinant SARS-CoV-2 variants in immunocompromised individuals

Biologists discover gene deletion behind abnormality in blood cancer cells

HIV patients on antiretroviral treatment with protease inhibitors may have lower COVID-19 risk

Researchers show how an important inhibitor binds to the A2A receptor

Study finds methylene blue is a low-micromolar inhibitor of the the SARS-CoV-2 spike protein and ACE2 interaction

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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