Clinical Trial News and Research

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DN-101 may protect against major side effects of chemotherapy

Men with advanced prostate cancer who take an experimental, high-dose vitamin D pill with chemotherapy live about eight months longer than those receiving chemotherapy and placebo, according to a new study.

3 Nov 2005

Lung cancer drug approved for treating pancreatic cancer

Genentech and OSI Pharmaceuticals have announced that U.S. regulators have approved their lung cancer drug Tarceva for the treatment of pancreatic cancer.

3 Nov 2005

"Screen and treat” cervical cancer programs effective in poorly resourced areas

According to a new study two "screen and treat" cervical cancer prevention programs developed for high-risk women in low-resource settings resulted in a lower prevalence of precancerous cervical lesions and cervical cancer, according to a study in the November 2 issue of JAMA: The Journal of the American Medical Association.

2 Nov 2005

Dendritic cells tricked into action against cancer

A new type of immunotherapy in which dendritic cells are tricked into action against cancer when they are exposed to harmless pieces of viruses and bacteria is described in the November issue of Cancer Research.

1 Nov 2005

Role of alpha tocopherol associated protein in prostate cancer

Researchers have identified a protein that disrupts an important signaling pathway in prostate cancer cells and suppresses growth of the cancer.

1 Nov 2005

Paclitaxel may help treat scleroderma

Using a novel model for scleroderma, researchers from Duke University Medical Center have discovered two important insights into this devastating disorder - the anti-cancer drug paclitaxel (Taxol) may prevent the skin thickening and small blood vessel destruction that characterizes the disease.

1 Nov 2005

Stereotactic body radiation therapy safe and effective way to treat early stage lung cancer in medically inoperable patients

Lung cancer patients with extenuating health problems may have an alternative to traditional radiation therapy through a lung-sparing procedure pioneered at the Indiana University School of Medicine.

1 Nov 2005

INTERACT trial to look at effects of early intensive blood pressure lowering on death and disability in stroke patients

A large clinical trial called INTERACT, launched in China this month, will determine the effects of early intensive blood pressure lowering on death and disability in stroke patients.

1 Nov 2005

Buccal mucosa may help test for lung cancer

In a new study presented at CHEST 2005, the 71st annual international scientific assembly of the American College of Chest Physicians (ACCP), scientists found that buccal mucosa, or cells scraped from the inner part of the cheek, may contain information that separates patients with lung cancer from high-risk negatives

1 Nov 2005

Bumetanide may help treat seizures in newborns

A diuretic drug called bumetanide may serendipitously help treat seizures in newborns, which are difficult to control with existing anticonvulsants, according to a study in the November Nature Medicine.

1 Nov 2005

$107.6 million grant for malaria vaccine candidate

In an important step toward developing an effective malaria vaccine, the Bill & Melinda Gates Foundation has announced a $107.6 million grant to the PATH Malaria Vaccine Initiative (MVI) to extend the public-private partnership between MVI and GlaxoSmithKline Biologicals (GSK Bio) to develop GSK Bio's malaria vaccine for children in Africa.

30 Oct 2005

Rimonabant appears to be very promising, especially for the treatment of patients with abdominal obesity

Overweight or obese people who are stout around the waist and abdomen are particularly at high risk for developing type 2 diabetes and high blood pressure.

30 Oct 2005

Cardiac regeneration using stem cells may heal hearts even years after heart attacks

Left ventricular function and exercise capacity increased, while the area of heart muscle damage shrank, in 18 patients given infusions of their own bone marrow stem cells up to eight years after a heart attack, according to a new study in the Nov. 1, 2005, issue of the Journal of the American College of Cardiology.

27 Oct 2005

Can strength-training exercises reduce or prevent lymphedema symptoms in breast cancer?

In a novel research study to begin this week at the Abramson Cancer Center of the University of Pennsylvania, Kathryn Schmitz, PhD, MPH, Assistant Professor in Epidemiology, will help to determine the extent to which a slowly progressive program of strength-training exercises is safe for breast cancer survivors with and without symptoms of lymphedema.

25 Oct 2005

COLD-fX reduces colds

The results of a new study to be published in the Canadian Medical Association Journal show that COLD-fX, an anti-flu, anti-cold pill, reduced the incidence and frequency of recurrent colds by more than half. It also cut the duration of colds and significantly reduced their severity.

25 Oct 2005

Electronic health record-based clinical trial alert system increases recruitment rates

An electronic health record-based clinical trial alert system increased recruitment rates and physicians' participation in an ongoing clinical trial, according to a study in the October 24 issue of Archives of Internal Medicine.

25 Oct 2005

Electronic medical records ideal for clinical trial recruitment

Electronic medical records are touted as a great way to prevent medical errors, but researchers are reporting that this new technology may also be just what the doctor ordered for clinical trial recruitment.

24 Oct 2005

NK-1 receptor antagonists very effective at reducing vomiting after surgery

The results of a new Phase III clinical trial have demonstrated that a new class of drugs, called "NK-1 receptor antagonists," is more effective at reducing vomiting after surgery than the most commonly used drug, according to the Duke University Medical Center researchers who led the trial.

24 Oct 2005

Botulinum toxin successfully treats trigeminal neuralgia

There is another use for botulinum toxin which has brought relief to some who suffer from migraines and eye spasms. Botulinum toxin can also successfully treat intense facial pain called trigeminal neuralgia, according to a study published in the October 25, 2005, issue of Neurology

24 Oct 2005

New device offers potential for accurate and reliable monitoring of brain oxygenation during cardiac surgeries

A new device that uses near-infrared light to non-invasively monitor the oxygenation of the brain during surgery appears to be a promising alternative to the more invasive techniques currently in use, according to a new study by Duke University Medical Center anesthesiologists.

23 Oct 2005

Clinical Trial News and Research

DN-101 may protect against major side effects of chemotherapy

Lung cancer drug approved for treating pancreatic cancer

"Screen and treat” cervical cancer programs effective in poorly resourced areas

Dendritic cells tricked into action against cancer

Role of alpha tocopherol associated protein in prostate cancer

Paclitaxel may help treat scleroderma

Stereotactic body radiation therapy safe and effective way to treat early stage lung cancer in medically inoperable patients

INTERACT trial to look at effects of early intensive blood pressure lowering on death and disability in stroke patients

Buccal mucosa may help test for lung cancer

Bumetanide may help treat seizures in newborns

$107.6 million grant for malaria vaccine candidate

Rimonabant appears to be very promising, especially for the treatment of patients with abdominal obesity

Cardiac regeneration using stem cells may heal hearts even years after heart attacks

Can strength-training exercises reduce or prevent lymphedema symptoms in breast cancer?

COLD-fX reduces colds

Electronic health record-based clinical trial alert system increases recruitment rates

Electronic medical records ideal for clinical trial recruitment

NK-1 receptor antagonists very effective at reducing vomiting after surgery

Botulinum toxin successfully treats trigeminal neuralgia

New device offers potential for accurate and reliable monitoring of brain oxygenation during cardiac surgeries

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