Clinical Trial News and Research

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Researchers learn to rapidly rebuild immunity in immune-suppressed cancer patients

Patients with multiple myeloma suffer from a malignant proliferation of plasma cells in their bone marrow. The standard treatment for this form of cancer is high-dose chemotherapy and transplantation of one's own blood-producing adult stem cells; however, this aggressive treatment wipes out the mature immune-system cells of patients – leaving them vulnerable to infection.

20 Oct 2005

Zambia to try 'herbal remedy' as a treatment for HIV/AIDS

The United Nations paints a grim picture of the health situation in Zambia. One in every six adults in Zambia is living with HIV, life expectancy at birth is below 40 years and 630,000 children in Zambia are AIDS orphans.

20 Oct 2005

Herceptin results "quite remarkable"

The targeted drug trastuzumab, or Herceptin, previously shown to prolong survival in advanced breast cancer, dramatically reduced the chances of recurrence in patients with early-stage disease when given for one year following standard chemotherapy.

19 Oct 2005

Possible new combination treatment regimen for patients with head and neck cancers who develop a second tumor

Few treatment options exist for patients with head and neck cancers who develop a second tumor or whose disease recurs in an area that has previously received radiation. Data from an international study reveal a possible new combination treatment regimen that offers a significant survival advantage for many of these patients.

18 Oct 2005

Largest known series of data examining the sequencing of tamoxifen and radiation

Fox Chase Cancer Center researchers say the sequence of tamoxifen and radiation following lumpectomy for early-stage breast cancer patients does not affect disease control, survival or complication rates, but administering tamoxifen concurrently with radiation has negative cosmetic results.

16 Oct 2005

Experimental HIV vaccine progresses in trials

A novel vaccine targeted to multiple HIV subtypes found worldwide has moved into the second phase of clinical testing, the National Institute of Allergy and Infectious Diseases (NIAID) announced today.

11 Oct 2005

Cholesterol levels among older adults has declined significantly

The total cholesterol level among older adults has declined significantly, while there has been little change among younger adults, according to a study in the October 12 issue of JAMA: The Journal of the American Medical Association.

11 Oct 2005

Nabi Biopharmaceuticals granted Staphylococcus Antigen and Vaccine patent

Nabi Biopharmaceuticals has announced that it has been granted U.S. Patent No. 6,936,258 entitled "Staphylococcus Antigen and Vaccine" by the U.S. Patent and Trademark Office for the composition of a strategically important glycoprotein-based antigen (GP-1) associated with three Staphylococcal strains: S. epidermidis, S. haemolyticus and S. hominis.

11 Oct 2005

Arena Pharmaceuticals issue new patent

Arena Pharmaceuticals has announced that it was issued US patent number 6,953,787, entitled "5-HT2C Receptor Modulators," by the United States Patent and Trademark Office.

11 Oct 2005

People only need to walk up to 12 miles per week or for about 125 to 200 minutes per week to improve their heart health

The amount of exercise may be more important than intensity to improve cardiovascular health, according to a new analysis of the first randomized clinical trial evaluating the effects of exercise amount and intensity in sedentary overweight men and women.

10 Oct 2005

Potential new treatment for stroke

"The study was designed to test if IL-1ra is safe in stroke patients and showed promising results," said Professor Rothwell, a world-renowned neuroscientist based in the University's Faculty of Life Sciences.

From The University of Manchester 10 Oct 2005

100% efficacy for cervical cancer vaccine

Final-stage clinical trials of a cervical cancer vaccine developed by University of Queensland (UQ) scientists, have shown the drug to be 100 per cent effective.

10 Oct 2005

Actos reduces the combined risk of non-fatal heart attacks, strokes in patients with type-2 diabetes

A study published in The Lancet shows that Takeda's Actos (pioglitazone HCl), an oral glucose lowering medication, significantly reduces the combined risk of non-fatal heart attacks, strokes and deaths by an additional 16% on top of standard medication

10 Oct 2005

Gut antibody could prove to be a promising drug target for Crohn's disease

A collaboration led by the Burnham Institute for Medical Research has found that an antibody which binds to an unusual sugar molecule residing in the gut halts the inflammation seen in Crohn's disease and other intestinal inflammations. The antibody could prove to be a promising drug target for these common chronic intestinal disorders.

9 Oct 2005

Tissue engineering used to reconstruct defective tracheas (windpipes) in fetal lambs

Researchers at Children's Hospital Boston report using tissue engineering to reconstruct defective tracheas (windpipes) in fetal lambs, first using cells from the amniotic fluid to grow sections of cartilage tube, and then implanting these living grafts into the lambs while still in the womb.

9 Oct 2005

Cost-effectiveness of potentially life-saving implantable cardioverter defibrillators (ICD) is an important public health issue

The use of implanted defibrillators that keep the heart beating in proper electrical rhythm to prevent cardiac arrest appears to be cost-effective for those patients who receive a significant mortality reduction, according to researchers from Duke Clinical Research Institute (DCRI), Stanford University and the VA Palo Alto Health Care System, Calif. They analyzed eight clinical trials of the devices to arrive at their conclusion.

5 Oct 2005

PACs should not be used routinely in patients in intensive care units with severe heart failure

The use of a pulmonary artery catheter (PAC) -- a device used for more than 30 years to assess cardiovascular health and to help guide the treatment of critically ill patients -- does not appear to improve outcomes nor confer added risks to patients.

4 Oct 2005

Johns Hopkins awarded $12 million to study how stem cell therapies can be used to treat hearts damaged by heart attack

Heart specialists at Johns Hopkins Heart Institute have been awarded more than $12 million from the National Heart, Lung, and Blood Institute (NHLBI) to study how stem cell therapies can be used to treat hearts damaged by heart attack or heart failure.

4 Oct 2005

Lack of oxygen in body tissues creates a defect of red blood cells that further exacerbates the condition by constricting blood vessels in the lung

What's more, the team demonstrated through studies in people and animals that inhalation of a 'souped up' form of nitric oxide, which targets red blood cells, reverses the blood abnormality to restore normal lung pressure.

3 Oct 2005

Potential beneficial effect of copper orotate

As one of the services for patients with Alzheimer's disease, the Department of Psychiatry at the Saarland University Medical Center offers participation in a clinical phase II trial. This clinical trial aims to elucidate a potential beneficial effect of copper orotate (an organic copper salt), which is given together with a standard cholinesterase inhibitor.

3 Oct 2005

Clinical Trial News and Research

Researchers learn to rapidly rebuild immunity in immune-suppressed cancer patients

Zambia to try 'herbal remedy' as a treatment for HIV/AIDS

Herceptin results "quite remarkable"

Possible new combination treatment regimen for patients with head and neck cancers who develop a second tumor

Largest known series of data examining the sequencing of tamoxifen and radiation

Experimental HIV vaccine progresses in trials

Cholesterol levels among older adults has declined significantly

Nabi Biopharmaceuticals granted Staphylococcus Antigen and Vaccine patent

Arena Pharmaceuticals issue new patent

People only need to walk up to 12 miles per week or for about 125 to 200 minutes per week to improve their heart health

Potential new treatment for stroke

100% efficacy for cervical cancer vaccine

Actos reduces the combined risk of non-fatal heart attacks, strokes in patients with type-2 diabetes

Gut antibody could prove to be a promising drug target for Crohn's disease

Tissue engineering used to reconstruct defective tracheas (windpipes) in fetal lambs

Cost-effectiveness of potentially life-saving implantable cardioverter defibrillators (ICD) is an important public health issue

PACs should not be used routinely in patients in intensive care units with severe heart failure

Johns Hopkins awarded $12 million to study how stem cell therapies can be used to treat hearts damaged by heart attack

Lack of oxygen in body tissues creates a defect of red blood cells that further exacerbates the condition by constricting blood vessels in the lung

Potential beneficial effect of copper orotate

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