Clinical Trial News and Research

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HeartMate XVE left ventricular assist device

Nine years ago this week, a team of University of Michigan doctors gave a dying heart patient a second chance at life by implanting a high-tech pump in his chest. The high-risk procedure was the first in Michigan performed using a new blood-pumping device called a HeartMate XVE left ventricular assist device, which helped the patient live until he received a heart transplant five weeks later.

28 Sep 2005

Possible new therapy for lymphoma and leukemia patients

Marty Holmes, a landscaper from Stockton, Calif., had never heard of a regulatory T cell before his doctor suggested that it could be the key to helping him survive his cancer.

28 Sep 2005

Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in children

The Nonalcoholic Steatohepatitis (NASH) Clinical Research Network has launched its second clinical trial to study NASH, a liver disease that resembles alcoholic liver disease but occurs in patients who drink little or no alcohol. The first trial, launched in January of this year, focuses on adults, while the second trial studies the disease in children.

27 Sep 2005

Benefits of statin therapy identified

The greater the reduction in LDL (lower-density lipoprotein) cholesterol achieved by statin therapy the greater the reduction in incidence of major coronary events, coronary revascularisation and stroke, concludes a meta-analysis published online today by The Lancet.

27 Sep 2005

Cancer vaccine based on the bacterium Listeria monocytogenes, can cure mice with breast tumors

A team from the University of Pennsylvania School of Medicine has shown that by using a cancer vaccine based on the bacterium Listeria monocytogenes, they can cure mice with established breast tumors. Cancer vaccines, which are more properly described as immunotherapy, work by boosting an immune response against tumor-associated antigens.

27 Sep 2005

Artificial Cervical (neck) Disc for treatment of degenerative disc disease

Rush University Medical Center is one of the few sites in the country selected to participate in a clinical trial for the Artificial Cervical (neck) Disc, the latest technology in the field.

27 Sep 2005

Increlex - first major innovation in 20 years for the treatment of growth failure

Rush University Medical Center is participating in a clinical trial to evaluate the potential benefit of the first major innovation in 20 years for the treatment of growth failure.

26 Sep 2005

Women with postmenopausal osteoporosis prefer once monthly to weekly treatment

Over 70% of postmenopausal women with Osteoporosis who expressed a preference, preferred once-monthly Bonviva, finding it more convenient than a once-weekly treatment. This is according to new data presented at the 27th Annual Meeting of the American Society for Bone Mineral Research (ASBMR).

26 Sep 2005

CytRx granted "Fast Track" designation for ALS drug

CytRx Corporation today announced that the U.S. Food and Drug Administration (FDA) has granted "Fast Track" designation for the company's leading drug candidate arimoclomol for the treatment of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease).

26 Sep 2005

Clinical trial participants may not be as unrepresentative of general clinical populations as often reported

It is often suggested that the results of clinical trials are affected by the fact that the patients who volunteer for a trial are more likely to take their medication effectively than those in standard care. This supposition is, however, strongly refuted in the results of a new study revealed at the British Pharmaceutical Conference in Manchester.

26 Sep 2005

Neurologix announces positive interim results of gene therapy clinical trial for patients with Parkinson's disease

Neurologix has announced positive interim results of its landmark gene therapy clinical trial for patients with Parkinson's disease. Neurologix's 12-patient, dose-escalating Phase I trial is the world's first study to use a viral vector (the non-pathogenic adeno-associated virus, or AAV) for the treatment of an adult neurological disease.

26 Sep 2005

Abatacept, marketed as Orencia appears to offer pain relief and increased mobility to rheumatoid arthritis patients

A new drug appears to offer pain relief and increased mobility to rheumatoid arthritis patients who have exhausted their other medical treatment options.

21 Sep 2005

Important new lessons learned from aspirin

No other medicine is as common, inexpensive, and yet powerful in so many ways as aspirin; yet despite a century of experience with the drug, researchers are still learning important new lessons, while raising new questions, according to seven special articles in the Sept. 20, 2005, issue of the Journal of the American College of Cardiology.

20 Sep 2005

Periodontal disease develops much earlier than dentists and other health professionals thought

Periodontal disease -- a progressive, eventually painful and disruptive condition in which bacteria attack gums and the hidden roots of teeth -- develops much earlier than dentists and other health professionals thought, a major new study concludes.

20 Sep 2005

Compounds found in broccoli, cauliflower, and watercress block lung cancer progression

A family of compounds found in cruciferous vegetables, such as broccoli, cauliflower, and watercress, blocked lung cancer progression in both animal studies and in tests with human lung cancer cells, report researchers from Georgetown University Medical Center and the Institute for Cancer Prevention.

19 Sep 2005

Drug AMD-3100 may help cancer patients who need stem cell transplants

A new drug may help cancer patients mobilize the cells necessary to restore their blood-forming system after high-dose chemotherapy, according to results from a clinical trial at the Kimmel Cancer Center at Thomas Jefferson University Hospital in Philadelphia and at other centers across the nation.

19 Sep 2005

Helix receives approval to conduct a clinical trial of Topical Interferon Alpha-2b in Sweden

Helix BioPharma today announced that it has received approval from Sweden's drug regulatory authority, the Medical Products Agency (MPA), to conduct a Phase II clinical trial of Topical Interferon Alpha-2b in patients with ano-genital warts (condylomata acuminata), who are positive for infection with the human papilloma virus (HPV).

12 Sep 2005

A breakthrough in R&D for neglected diseases

A dramatic sea-change in research into ten so-called "neglected diseases," such as malaria, leprosy and sleeping sickness, could result in at least eight new drugs being developed by 2010.

12 Sep 2005

Innovative new technique of partial breast irradiation for early stage breast cancer

An innovative new technique of partial breast irradiation for early stage breast cancer has been developed in Canada. This technique, a world first, was presented at the annual scientific meeting of the Canadian Association of Radiation Oncologists this week.

10 Sep 2005

Letrozole following tamoxifen may benefit women with breast cancer

Switching to the drug letrozole following 5 years of treatment with tamoxifen reduces the risk of hormone-dependent breast cancer recurrence, but not overall survival, among postmenopausal women, according to a new study in the September 7 issue of the Journal of the National Cancer Institute.

7 Sep 2005

Clinical Trial News and Research

HeartMate XVE left ventricular assist device

Possible new therapy for lymphoma and leukemia patients

Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in children

Benefits of statin therapy identified

Cancer vaccine based on the bacterium Listeria monocytogenes, can cure mice with breast tumors

Artificial Cervical (neck) Disc for treatment of degenerative disc disease

Increlex - first major innovation in 20 years for the treatment of growth failure

Women with postmenopausal osteoporosis prefer once monthly to weekly treatment

CytRx granted "Fast Track" designation for ALS drug

Clinical trial participants may not be as unrepresentative of general clinical populations as often reported

Neurologix announces positive interim results of gene therapy clinical trial for patients with Parkinson's disease

Abatacept, marketed as Orencia appears to offer pain relief and increased mobility to rheumatoid arthritis patients

Important new lessons learned from aspirin

Periodontal disease develops much earlier than dentists and other health professionals thought

Compounds found in broccoli, cauliflower, and watercress block lung cancer progression

Drug AMD-3100 may help cancer patients who need stem cell transplants

Helix receives approval to conduct a clinical trial of Topical Interferon Alpha-2b in Sweden

A breakthrough in R&D for neglected diseases

Innovative new technique of partial breast irradiation for early stage breast cancer

Letrozole following tamoxifen may benefit women with breast cancer

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