Clinical Trial News and Research

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Phase II clinical study of ularitide

The European Society of Cardiology (ESC) today highlighted results of a Phase II clinical study of ularitide, a synthetic form of a natriuretic peptide synthesized in the kidney for patients with acute decompensated congestive heart failure (ADHF).

5 Sep 2005

Use of the antiplatelet drug clopidogrel before a coronary angioplasty reduces risk of cardiovascular death

Use of the antiplatelet drug clopidogrel before a coronary angioplasty reduced the risk of cardiovascular death, heart attack or stroke within 30 days following the procedure, according to an article in the September 14 issue of JAMA: The Journal of the American Medical Association.

5 Sep 2005

Can a new combination treatment prevent a secondary stroke in children with sickle cell anemia?

St. Jude Children’s Research Hospital will lead a national Phase III clinical trial to investigate whether a new combination treatment can prevent a secondary stroke in children with sickle cell anemia (SCA) and eliminate the need for nightly injections with a drug that reduces iron overload in these patients.

1 Sep 2005

Rev/Dex combo looks like a breakthrough treatment for multiple myeloma

Mayo Clinic Cancer Center investigators report that combination therapy with lenalidomide (Revlimid) and dexamethasone (combination is called Rev/Dex) looks like a breakthrough treatment for multiple myeloma. Results of a Phase II clinical trial were published online Aug. 23 in Blood.

1 Sep 2005

Contraceptive pill controls severe premenstrual disorder

According to a new study, a low dose oral contraceptive works as a treatment for the most severe form of premenstrual syndrome, premenstrual dysphoric disorder (PMDD).

1 Sep 2005

Low dose oral contraceptive effective in controlling premenstrual disorder

A new study led by researchers at Yale School of Medicine shows for the first time that a low dose oral contraceptive with a unique progestin and dosing regimen is effective in treating symptoms of premenstrual dysphoric disorder (PMDD), the most severe form of premenstrual syndrome.

31 Aug 2005

Blocking Hutchinson-Gilford progeria syndrome (HGPS) with anticancer drugs

A class of anticancer drugs currently being evaluated in phase 3 clinical trials may also be an effective treatment for Hutchinson-Gilford progeria syndrome (HGPS), a fatal genetic disorder that causes premature aging.

29 Aug 2005

Drugs known as farnesyltransferase inhibitors (FTIs) may hold promise for premature aging disorder

In a surprising development, a research team led by the National Human Genome Research Institute (NHGRI), has found that a class of experimental anti-cancer drugs also shows promise in laboratory studies for treating a fatal genetic disorder that causes premature aging.

29 Aug 2005

Early statin therapy may be essential for reducing mortality and other complications in heart attack victims

In the largest clinical study of its kind, UCLA researchers found that early treatment with a statin drug within 24 hours of having a heart attack reduced in-hospital mortality rates by over 50 percent.

29 Aug 2005

Compound might defeat African sleeping

One of the most devastating diseases in sub-Saharan Africa almost disappeared in the late 1950s.

26 Aug 2005

First clinical trial of a biologic nanoparticle designed to give back to cancer patients the tumor-busting gene they have lost

The phase I clinical study will enroll 20 patients with advanced solid cancers (including most common tumor types), and is the culmination of more than a decade of work by a team of researchers led by Professor Esther H. Chang, Ph.D. at the Lombardi Comprehensive Cancer Center.

25 Aug 2005

Stem cells with heart bypass surgery trial to begin

The University of Pittsburgh Medical Center (UPMC) has been granted approval by the U.S. Food and Drug Administration (FDA) to conduct a clinical trial to determine the safety and feasibility of injecting a patient's own bone marrow-derived stem cells directly into the heart during conventional heart bypass surgery.

25 Aug 2005

Experimental immunusuppressant drug preserves transplanted kidneys

An international team of transplant physicians has shown that the investigational drug belatacept (LEA29Y) preserves transplanted kidney function as effectively as cyclosporine, the drug most commonly used to prevent the immune system from rejecting transplanted organs.

24 Aug 2005

New drug that selectively blocks immune responses protects kidneys after transplant

In an international clinical trial, a new drug that selectively blocks immune responses has proved as effective in preventing acute kidney transplant rejection as cyclosporine, the standard anti-rejection treatment.

24 Aug 2005

No intervention is necessary for most children with fluid in their ears

A Children's Hospital of Pittsburgh study finds that prompt insertion of tympanostomy tubes (small ear tubes) does not improve developmental outcomes of children at 6 years of age as once thought.

24 Aug 2005

Women think very rationally about breast cancer surgery from their own perspectives

When a woman is diagnosed with breast cancer, her top priority is to get the cancer out and reduce the odds that it will ever return. But for some women just getting the cancer out doesn't feel like enough.

22 Aug 2005

Experimental vaccine can prime the immune system to help fight an aggressive form of lymphoma

Researchers at The University of Texas M. D. Anderson Cancer Center and the National Cancer Institute have found that an experimental vaccine can prime the immune system to help fight an aggressive form of lymphoma, even though prior therapy had eliminated virtually all of the B cells thought necessary to mount such a defense.

22 Aug 2005

Enzyme in the blood that could be a potential marker for heart failure

A team of scientists led by Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine in Jefferson Medical College of Thomas Jefferson University in Philadelphia, previously showed that an enzyme called GRK2 or beta-adrenergic kinase (ßARK1) is critically important in heart function.

22 Aug 2005

Many phase I trials for new cancer fighting drugs never get reported in peer-reviewed journals

A new study finds many phase I trials for new cancer fighting drugs never get reported in peer-reviewed journals, and says investigators should be committed not just to finding novel compounds, but also to make sure final results of their studies be disseminated to the medical community.

22 Aug 2005

Women whose breast cancer is detected by mammography have a significantly better prognosis

Women whose breast cancer was detected by screening mammography had a significantly better prognosis than those whose cancer was found another way - even if the cancer had already spread to their lymph nodes, say researchers at The University of Texas M. D. Anderson Cancer Center who looked at outcomes from randomized screening studies of more than 150,000 women.

17 Aug 2005

Clinical Trial News and Research

Phase II clinical study of ularitide

Use of the antiplatelet drug clopidogrel before a coronary angioplasty reduces risk of cardiovascular death

Can a new combination treatment prevent a secondary stroke in children with sickle cell anemia?

Rev/Dex combo looks like a breakthrough treatment for multiple myeloma

Contraceptive pill controls severe premenstrual disorder

Low dose oral contraceptive effective in controlling premenstrual disorder

Blocking Hutchinson-Gilford progeria syndrome (HGPS) with anticancer drugs

Drugs known as farnesyltransferase inhibitors (FTIs) may hold promise for premature aging disorder

Early statin therapy may be essential for reducing mortality and other complications in heart attack victims

Compound might defeat African sleeping

First clinical trial of a biologic nanoparticle designed to give back to cancer patients the tumor-busting gene they have lost

Stem cells with heart bypass surgery trial to begin

Experimental immunusuppressant drug preserves transplanted kidneys

New drug that selectively blocks immune responses protects kidneys after transplant

No intervention is necessary for most children with fluid in their ears

Women think very rationally about breast cancer surgery from their own perspectives

Experimental vaccine can prime the immune system to help fight an aggressive form of lymphoma

Enzyme in the blood that could be a potential marker for heart failure

Many phase I trials for new cancer fighting drugs never get reported in peer-reviewed journals

Women whose breast cancer is detected by mammography have a significantly better prognosis

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