Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Evaluating serum levels of S100A9 as an inflammatory marker of unfavorable outcomes in patients with COVID-19

Investigators demonstrated S100A9 as an inflammatory biomarker among hospitalized SARS-CoV-2 patients.

20 May 2022

Molecular profiling of diseased joints could transform treatment for rheumatoid arthritis patients

New research from Queen Mary University of London, published in Nature Medicine, has shown that molecular profiling of the diseased joint tissue can significantly impact whether specific drug treatments will work to treat rheumatoid arthritis (RA) patients.

19 May 2022

Using 'off-the-shelf' engineered stem cell based therapy for treating glioblastomas post-surgery

Glioblastomas (GBMs) are highly aggressive cancerous tumors of the brain and spinal cord. Brain cancers like GBM are challenging to treat because many cancer therapeutics cannot pass through the blood-brain barrier, and more than 90 percent of GBM tumors return after being surgically removed, despite surgery and subsequent chemo- and radiation therapy being the most successful way to treat the disease.

19 May 2022

New, minimally invasive biomarker-based strategy 90% successful in detecting esophageal cancer

In a small but rigorous pilot study, Johns Hopkins Medicine researchers have shown that a novel, minimally invasive biomarker-based strategy they developed was 90% successful in detecting esophageal squamous cell carcinoma (ESCC), the predominant subtype of esophageal cancer worldwide.

18 May 2022

Study identifies cancer biomarkers based on a type of genetic modification

Biomarkers are often used during the management of cancer to guide treatment decisions and predict patient outcomes. However, it is often difficult to identify appropriate biomarkers that can be consistently reproduced and are easily analyzed with limited patient specimens.

18 May 2022

Excessive gestational weight gain linked with higher cardiovascular risk profile in midlife

Pregnant women with excessive gestational weight gain had a higher cardiovascular risk profile in midlife, according to a new study published in the peer-reviewed Journal of Women's Health.

16 May 2022

Novel technique to measure sperm age may help predict pregnancy success

A novel technique to measure the age of male sperm has the potential to predict the success and time it takes to become pregnant, according to a newly published study by researchers at the Wayne State University School of Medicine.

13 May 2022

The potential role of the gut microbiome in modifying patient responses to statin therapy

Researchers discovered strong links between human gut microbiome makeup and statin on- and off-target effects, probably beneficial in medication tailoring.

13 May 2022

Blood adenosine levels positively correlate to the white matter lesions in very low birth weight premature infants

Prematurity affects about 10% of pregnancies worldwide each year. In about 20% of very low birth weight (VLBW) premature infants, punctate white matter lesions (PWML) can be diagnosed at MRI at term equivalent age.

13 May 2022

Penn study finds low uptake of first mutation-targeted bladder cancer drug

The first bladder cancer drug targeting a cancer-driving gene mutation has been used relatively little despite its clear efficacy in a clinical trial, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

12 May 2022

Children exposed to maltreatment present a response-to-stress pattern like that of adolescents

The acute psychosocial stress states stimulate the secretion of an antibody type protein which is decisive in the first immune defence against infection, but only after puberty. However, children with a history of maltreatment present a similar response to that of adolescents, which suggests there is an early maturation of the immune system in these cases.

11 May 2022

New classification by ESMO to guide research on treatment de-escalation in oncology

ESMO, the leading professional organization for medical oncology, has developed a new evidence-based classification to guide research and interpretation of data on treatment de-escalation in oncology.

11 May 2022

Cancer cells in an acidic environment undergo lipid synthesis and accumulation, study shows

Alterations in metabolic processes are a hallmark of cancer and can lead to a tumor environment that is acidic. As a result, cancer cells must adapt to survive in this inhospitable environment.

10 May 2022

Telltale signs of concussions may be found in the gut, study suggests

A recently published study by Houston Methodist scientists suggests telltale signs of concussions might be found in the gut.

10 May 2022

Study uncovers new regulator of prostate cancer metastasis

A transcription factor normally associated with androgen receptor activity in prostate cancer has a newly discovered role in controlling lipid biosynthesis, according to a Northwestern Medicine study published in Nature Genetics.

10 May 2022

New wearable can continuously monitor several health stats simultaneously in real-time

Imagine being able to measure your blood sugar levels, know if you've had too much to drink, and track your muscle fatigue during a workout, all in one small device worn on your skin.

9 May 2022

Study confirms accuracy of new generation GastroPanel® test

A clinical validation study conducted at Oulu University Hospital (OUH) has confirmed the high accuracy of BIOHIT Oyj’s new generation GastroPanel® test for the diagnosis of atrophic gastritis (AG) and Helicobacter pylori (Hp) infection in patients referred for gastroscopy.

From BIOHIT HealthCare Ltd 6 May 2022

Endocrine-disrupting chemicals may be linked with lower bone mineral density in male teens

Per- and polyfluoroalkyl substances (PFAS) and phthalates (two types of endocrine-disrupting chemicals) may be associated with lower bone mineral density in male teens, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism.

4 May 2022

Elevated levels of PHGDH enzyme associated with Alzheimer’s disease pathology

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer's disease, and a study led by the University of California San Diego provides new evidence to support this claim.

4 May 2022

Multi-omics identify COVID-19 severity predictors and prothrombotic signatures in patients with end-stage kidney disease

Researchers demonstrated that plasma levels of leucine-rich repeat-containing 15 are a strong indicator of the severity of COVID-19 in patients with end-stage kidney disease.

3 May 2022

Biomarker News and Research

Further Reading

Evaluating serum levels of S100A9 as an inflammatory marker of unfavorable outcomes in patients with COVID-19

Molecular profiling of diseased joints could transform treatment for rheumatoid arthritis patients

Using 'off-the-shelf' engineered stem cell based therapy for treating glioblastomas post-surgery

New, minimally invasive biomarker-based strategy 90% successful in detecting esophageal cancer

Study identifies cancer biomarkers based on a type of genetic modification

Excessive gestational weight gain linked with higher cardiovascular risk profile in midlife

Novel technique to measure sperm age may help predict pregnancy success

The potential role of the gut microbiome in modifying patient responses to statin therapy

Blood adenosine levels positively correlate to the white matter lesions in very low birth weight premature infants

Penn study finds low uptake of first mutation-targeted bladder cancer drug

Children exposed to maltreatment present a response-to-stress pattern like that of adolescents

New classification by ESMO to guide research on treatment de-escalation in oncology

Cancer cells in an acidic environment undergo lipid synthesis and accumulation, study shows

Telltale signs of concussions may be found in the gut, study suggests

Study uncovers new regulator of prostate cancer metastasis

New wearable can continuously monitor several health stats simultaneously in real-time

Study confirms accuracy of new generation GastroPanel® test

Endocrine-disrupting chemicals may be linked with lower bone mineral density in male teens

Elevated levels of PHGDH enzyme associated with Alzheimer’s disease pathology

Multi-omics identify COVID-19 severity predictors and prothrombotic signatures in patients with end-stage kidney disease

Event guide: World Clinical Biomarkers & CDx Summit Japan eBook

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