Immune Response News and Research

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Researchers develop potent yet low-inflammatory mRNA cancer vaccine vectors

Lipid nanoparticle (LNP)-based messenger ribonucleic acid (mRNA) vaccines have recently emerged as a promising strategy for the prevention and treatment of cancers, as well as infectious diseases.

4 Dec 2022

New Collaborative Research Center investigates how Treg cells influence immunological and tissue-specific diseases

The German Research Foundation (DFG) has approved the establishment and funding of the Collaborative Research Center/Transregio (CRC/TRR) 355 "Heterogeneity and functional specialization of regulatory T cells in distinct microenvironments".

2 Dec 2022

Vaccination against pertussis in pregnancy and outstanding scientific questions

A recent paper published in Vaccines summarized the data presented and the discussions in the meeting regarding pertussis vaccination in pregnancy (ViP).

2 Dec 2022

The effect of ubiquitination on SARS-CoV-2 infection and patient prognosis

A recent Clinical and Translational Medicine study utilized several published public datasets to evaluate the biological characteristics associated with the ubiquitination of patients infected with SARS-CoV-2.

2 Dec 2022

Scaling up the production of customized immune cells for drug development and testing

To prevent testing on animals and create even more precise ways of testing therapeutics, the pharmaceutical industry is increasingly turning to human immune cells.

1 Dec 2022

Two experimental mRNA vaccines highly effective in reducing malaria infection and transmission

Malaria is found in more than 90 countries around the world, causing 241 million cases and an estimated 627,000 deaths every year.

1 Dec 2022

Novel prefusion S antigen designed by the mutation of the SARS-CoV-2 Spike protein’s trimeric structure

Researchers mutated the SARS-CoV-2 spike protein's trimeric structure to design a novel prefusion S antigen, S2D14.

1 Dec 2022

The requirement for Fc effector functions to protect against SARS-CoV-2 infection

Researchers determined which specific fragment crystallizable effector functions protect against SARS-CoV-2 infection, especially its emerging variants.

1 Dec 2022

Detection of filoviruses by the innate immune system

In a new study, researchers examined how the innate immune system detects filoviruses.

1 Dec 2022

INPP5D gene plays key role in enabling microglial cells to prevent plaque buildup

A change in the DNA code (mutation) of a gene that plays a key role in the brain's immune defenses may prevent related cells from clearing away protein-filled clumps, a new study in mice shows.

30 Nov 2022

Study provides novel therapeutic targets for enhancing the antitumor immunity of γδ-T cells in diabetes

A research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) discovered that high glucose impairs the antitumor activity of immune effector γδ-T cells, which contributes to the increased cancer risk in diabetes and that metabolic reprogramming by glucose control may improve the antitumor activity of γδ-T cells.

30 Nov 2022

Detection of early-formed, antigen-specific clones in SARS-CoV-2-reactive B cells after longitudinal analysis

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, has globally infected more than 639 million individuals and claimed over 6.6 million lives. Despite the rapid commencement of COVID-19 vaccination programs in most countries across the world, the virus has remained in circulation.

30 Nov 2022

More than half of U.S. adults weren’t concerned about the flu season, survey shows

As flu-related hospitalizations soar to record early season levels, the American Heart Association, a global force for longer, healthier lives for all, is concerned many people will be caught off-guard by this health threat and urges prompt vaccination against the virus.

30 Nov 2022

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Researchers investigate the genetic, immunological, and evolutionary factors that determine the vast variability observed in clinical manifestations of COVID-19.

28 Nov 2022

Simultaneous radiation and immunotherapy can benefit mNSCLC patients with high tumor aneuploidy

In many cancer types, cancer cells try to survive by escaping attack from the immune system. These cancer cells hijack mechanisms called immune checkpoints to trick the immune system into thinking they are healthy cells.

28 Nov 2022

Scientists unravel how bats harbor many viruses without developing symptoms

Bats are asymptomatic carriers of a multitude of viruses that are pathogenic to most other mammals. How has their immune system evolved to shield them from these pathogens?

28 Nov 2022

The frequency, magnitude, and longevity of natural antibody responses against nine P. vivax vaccine candidate proteins

A new study aimed to evaluate the magnitude, longevity, and prevalence of naturally acquired IgG antibody responses against 9 P. vivax vaccine candidate antigens in patients with acute vivax malaria and were followed up for 180 days.

28 Nov 2022

Glycan signatures in rheumatic diseases and their associated functional implications

A new paper examines the understanding of glycosylation in an array of rheumatic diseases and indicates the potential for therapeutic interventions using the same mechanism.

28 Nov 2022

New technologies and recent advances in the study of T cells and T-cell epitope discovery in food allergy research

In a recent study, scientists reviewed the latest technological advancements and T cell epitope discovery associated with food allergy.

28 Nov 2022

Scientists develop preclinical model of scrub typhus disease

Scientists have developed an animal model of scrub typhus using outbred CD-1 mice. Using the model, they have characterized host susceptibility to the causative pathogen, disease pathogenesis, and immune responses. The study has been published in the journal PLOS Neglected Tropical Diseases.

27 Nov 2022

Immune Response News and Research

Researchers develop potent yet low-inflammatory mRNA cancer vaccine vectors

New Collaborative Research Center investigates how Treg cells influence immunological and tissue-specific diseases

Vaccination against pertussis in pregnancy and outstanding scientific questions

The effect of ubiquitination on SARS-CoV-2 infection and patient prognosis

Scaling up the production of customized immune cells for drug development and testing

Two experimental mRNA vaccines highly effective in reducing malaria infection and transmission

Novel prefusion S antigen designed by the mutation of the SARS-CoV-2 Spike protein’s trimeric structure

The requirement for Fc effector functions to protect against SARS-CoV-2 infection

Detection of filoviruses by the innate immune system

INPP5D gene plays key role in enabling microglial cells to prevent plaque buildup

Study provides novel therapeutic targets for enhancing the antitumor immunity of γδ-T cells in diabetes

Detection of early-formed, antigen-specific clones in SARS-CoV-2-reactive B cells after longitudinal analysis

More than half of U.S. adults weren’t concerned about the flu season, survey shows

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Simultaneous radiation and immunotherapy can benefit mNSCLC patients with high tumor aneuploidy

Scientists unravel how bats harbor many viruses without developing symptoms

The frequency, magnitude, and longevity of natural antibody responses against nine P. vivax vaccine candidate proteins

Glycan signatures in rheumatic diseases and their associated functional implications

New technologies and recent advances in the study of T cells and T-cell epitope discovery in food allergy research

Scientists develop preclinical model of scrub typhus disease

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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