Clinical Trial News and Research

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Drug combination of amodiaquine and sulfadoxinepyrimethamine might offer the optimal treatment for malaria

Results of a randomised trial from Uganda in this week’s issue of THE LANCET suggest that the drug combination of amodiaquine and sulfadoxinepyrimethamine might offer the optimal treatment for malaria in terms of efficacy and cost-effectiveness in this region.

29 Nov 2004

FDA approval of Tysabri, for the treatment of multiple sclerosis

Biogen and Elan Corporation have announced that the U.S. Food and Drug Administration (FDA) has approved Tysabri (natalizumab), as treatment for relapsing forms of multiple sclerosis (MS) to reduce the frequency of clinical relapses.

24 Nov 2004

FDA approves Tarceva (erlotinib)

OSI Pharmaceuticals and Genentech have announced that the U.S. Food and Drug Administration (FDA) has approved, after priority review, Tarceva (erlotinib) for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) after failure of at least one prior chemotherapy regimen.

20 Nov 2004

Premature infants with lung disease may continue to require replacement substance to ease breathing

Physicians have known for decades that many premature babies suffer respiratory problems stemming from insufficiency of a lung substance called surfactant during their first few weeks of life.

20 Nov 2004

Transcranial Magnetic Stimulation to treat major depression

Psychiatrists at Rush University Medical Center are testing a noninvasive technique that uses repeated short bursts of magnetic energy to stimulate nerve cells in the brain to treat major depression.

20 Nov 2004

Prolonged abstinence, no visual problems in patients taking GVG for meth/cocaine abuse

A second, small clinical trial of a proposed addiction treatment led by investigators at NYU School of Medicine and the U.S. Department of Energy's Brookhaven National Laboratory has produced favorable results in the treatment of long-term addiction to methamphetamine and/or cocaine, with no visual side effects in any of the 30 patients enrolled.

18 Nov 2004

Biotoxin from puffer fish may provide treatment for opioid withdrawal

On November 10, 2004 investigators involved in a Phase IIa clinical trial of the novel biotoxin Tetrodotoxin (TTX) for the treatment of opioid withdrawal enrolled their first participants.

18 Nov 2004

70% of cases of spina bifida are preventable by folic-acid supplementation

A seminar in this week’s issue of THE LANCET discusses the causes, symptoms, and treatments relating to spina bifida, and reinforces an important public-health message for women about to become pregnant

18 Nov 2004

Researchers find effective treatment for Unusual Fever Syndrome caused by cold exposure

Remember when Grandma used to say, "don’t go out in the cold; you’ll get sick”? It turns out that she was right for a small number of people who have a condition called familial cold autoinflammatory syndrome (FCAS)

16 Nov 2004

Vegetables such as cabbage, broccoli, sprouts or cauliflower could help in the fight against cancer

Researchers from the Wales College Of Medicine, Cardiff University in the UK have discovered what may be a clue to the prevention and treatment of cancer. They have found that when vegetables such as cabbage, broccoli, sprouts or cauliflower are eaten, they could help in the fight against cancer.

16 Nov 2004

Vasogen announces full patient enrollment in its trial of Celacade in peripheral arterial disease

Vasogen today announced that it has reached full enrollment in its 500-patient pivotal phase III SIMPADICO trial of Celacade (immune modulation therapy) for the treatment of peripheral arterial disease (PAD).

16 Nov 2004

36% of cancer patients ages 65 and older participate in clinical trials

A new study finds that only 36% of cancer patients ages 65 and older participate in clinical trials, despite making up 60% of the U.S. cancer population. The study will be published November 15 in the Journal of Clinical Oncology (JCO).

14 Nov 2004

All patients in study clear parasite that causes African sleeping sickness

Immtech International has announced that all 30 patients participating in the concluded Phase IIb extended dose regimen arm of its clinical trial of DB289 for treating African sleeping sickness cleared the parasite that causes African sleeping sickness within the treatment period, with no significant adverse results reported.

11 Nov 2004

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

Lorus Therapeutics today announced that its wholly owned subsidiary, GeneSense Technologies Inc., has been allowed a patent by the Canadian Patent Office entitled "Antitumor Antisense Sequences Directed Against R1 and R2 Components of Ribonucleotide Reductase."

10 Nov 2004

Dementia patients receiving long-term treatment with Reminyl may be able to stay at home for longer compared

Shire Pharmaceuticals Group has announced that Dementia patients receiving long-term treatment with Reminyl (more than 36 months) may be able to stay at home for longer compared to those receiving treatment for shorter periods of time.

10 Nov 2004

Heart jacket effective treatment for heart failure

The concept is simple: to halt deterioration of the heart muscle, wrap it in a mesh-like net to prevent further enlargement in patients with heart failure. It's like a jacket for the heart.

10 Nov 2004

A new medication has dramatically reduced mortality among African-American patients suffering from heart disease

A new medication has dramatically reduced mortality among African-American patients suffering from heart disease, according to results of a study including UT Southwestern Medical Center at Dallas researchers.

9 Nov 2004

BiDil demonstrates significant improvement in survival rates in African American heart failure patients

"African Americans suffer disproportionately from heart failure and until A-HeFT have been underrepresented in heart failure trials," said Malcolm Taylor, M.D., Chair of the Association of Black Cardiologists Committee on Heart Failure. "A-HeFT represents a significant step forward in addressing these disparities."

9 Nov 2004

Women who have diets rich in oils containing alpha-linolenic appear to have a lower risk of dying from heart disease

Women who reported eating diets rich in oils containing alpha-linolenic acid (ALA) seemed to have a lower risk of dying from heart disease and sudden cardiac death than women whose diets are low in the plant-derived fatty acid, researchers reported at the American Heart Association’s Scientific Sessions 2004.

9 Nov 2004

New valve repair device that could replace major heart surgery

The Hospital of the University of Pennsylvania (HUP) is participating in a nationwide clinical trial of a new valve repair device that could replace major heart surgery in some patients.

8 Nov 2004

Clinical Trial News and Research

Drug combination of amodiaquine and sulfadoxinepyrimethamine might offer the optimal treatment for malaria

FDA approval of Tysabri, for the treatment of multiple sclerosis

FDA approves Tarceva (erlotinib)

Premature infants with lung disease may continue to require replacement substance to ease breathing

Transcranial Magnetic Stimulation to treat major depression

Prolonged abstinence, no visual problems in patients taking GVG for meth/cocaine abuse

Biotoxin from puffer fish may provide treatment for opioid withdrawal

70% of cases of spina bifida are preventable by folic-acid supplementation

Researchers find effective treatment for Unusual Fever Syndrome caused by cold exposure

Vegetables such as cabbage, broccoli, sprouts or cauliflower could help in the fight against cancer

Vasogen announces full patient enrollment in its trial of Celacade in peripheral arterial disease

36% of cancer patients ages 65 and older participate in clinical trials

All patients in study clear parasite that causes African sleeping sickness

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

Dementia patients receiving long-term treatment with Reminyl may be able to stay at home for longer compared

Heart jacket effective treatment for heart failure

A new medication has dramatically reduced mortality among African-American patients suffering from heart disease

BiDil demonstrates significant improvement in survival rates in African American heart failure patients

Women who have diets rich in oils containing alpha-linolenic appear to have a lower risk of dying from heart disease

New valve repair device that could replace major heart surgery

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