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New study challenges dopamine's role in placebo effects and pain relief

New findings argue against a direct causal role for dopamine during the experience of a treatment effect in the establishment of positive treatment expectations and placebo analgesia in healthy volunteers, according to a study published September 24th in the open-access journal PLOS Biology by Ulrike Bingel from University Hospital Essen, Germany, and colleagues.

24 Sep 2024

Innovative HiTIP-seq method advances epigenetic research in pediatric brain tumors

Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical regions of the central nervous system, such as the pons, thalamus, and spinal cord.

24 Sep 2024

Brain connectivity changes after psilocybin treatment in body dysmorphic disorder patients

Body dysmorphic disorder (BDD) is a debilitating mental illness characterized by an obsessive preoccupation with perceived flaws in one's physical appearance.

24 Sep 2024

Johnson & Johnson seeks first approval of nipocalimab to treat broadest population living with antibody positive generalized myasthenia gravis

The BLA submission for nipocalimab marks a significant advancement in treating generalized myasthenia gravis, showing improved MG-ADL scores in clinical trials.

From Johnson & Johnson 24 Sep 2024

Neuroactive drugs show promising anti-glioblastoma effects in preclinical trials

Study explores the potential to repurpose neuroactive drugs, originally approved for neurological disorders, for the treatment of glioblastoma. Vortioxetine, an antidepressant, showed promising anti-glioblastoma activity, significantly reducing tumor size in preclinical trials.

24 Sep 2024

Research reveals disparities in diabetes drug efficacy for Black populations

New research analyzing the effects of two drugs used to treat type 2 diabetes indicates a consistent lack of cardiovascular and renal benefits in Black populations.

23 Sep 2024

Florida’s new covid booster guidance is straight-up misinformation

In what has become a pattern of spreading vaccine misinformation, the Florida health department is telling older Floridians and others at highest risk from covid-19 to avoid most booster shots, saying they are potentially dangerous.

23 Sep 2024

Triptans better at relieving migraine pain than recently marketed and more expensive drugs

A meta-analysis reveals triptans as the most effective acute migraine treatments, highlighting the need for their inclusion in the WHO Essential Medicines List.

23 Sep 2024

Dietary antigens reduce small intestine cancer by boosting immune T-cells

Study shows that dietary antigens can suppress small intestine carcinogenesis by activating T-cells through Peyer's patches. Adding bovine serum albumin (BSA) or ovalbumin (OVA) to antigen-free diets restored immune function and reduced tumor growth in mice.

22 Sep 2024

AI-driven urban planning models mislead public health interventions, study shows

AI models using Google Street View (GSV) for urban planning can lead to incorrect conclusions about public health, especially regarding obesity and diabetes. The study reveals that physical activity levels, not environmental features like sidewalks, are more impactful on health outcomes.

22 Sep 2024

Promising antidepressant offers hope for glioblastoma treatment

Glioblastoma is a particularly aggressive brain tumor that at present is incurable. Cancer doctors can extend patients' life expectancy through operations, radiation, chemotherapy or surgical interventions. Nevertheless, half of patients die within twelve months of diagnosis.

20 Sep 2024

Enhancing patient outcomes with AI-driven intratumoral immunotherapy

A new editorial was published in Oncotarget's Volume 15 on September 17, 2024, entitled, "The emerging role of AI in enhancing intratumoral immunotherapy care."

19 Sep 2024

Study reveals biomarkers that predict disability worsening in multiple sclerosis

A pioneering study presented today at ECTRIMS 2024 has identified critical biomarkers that can predict disability worsening in multiple sclerosis (MS).

19 Sep 2024

Researchers make strides in enhancing early diagnosis of bipolar disorder in adolescents

In a groundbreaking study in Biological Psychiatry, published by Elsevier, researchers report significant strides in enhancing early diagnosis of bipolar disorder in adolescents.

19 Sep 2024

Phase 1 trial shows safety and efficacy of personalized vaccine for lymphoplasmacytic lymphoma

A team of researchers from City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S., and The University of Texas M.D. Anderson Cancer Center, have reported safety and efficacy results from a Phase 1 trial that featured a personalized vaccine to treat lymphoplasmacytic lymphoma, a rare and slow-growing type of blood cancer, according to a study published recently in Nature Communications.

19 Sep 2024

Multiple myeloma drug shows efficacy in treating rare bleeding disorder

A drug approved for treating the blood cancer multiple myeloma may offer a safe and effective way to reduce the risk of severe nosebleeds from a rare but devastating bleeding disorder.

19 Sep 2024

Asimov launches AAV Edge, a suite of AI models, host cells, and genetic tools for end-to-end gene therapy development

Asimov, the synthetic biology company advancing the design and production of therapeutics, today announced the launch of the AAV Edge System, a comprehensive suite of tools for adeno-associated viral (AAV) gene therapy design and manufacturing.

18 Sep 2024

Therapeutic inertia in the treatment of women with multiple sclerosis revealed

A study has revealed significant therapeutic inertia in the treatment of women with multiple sclerosis (MS), highlighting gender disparities that could impact long-term health outcomes for women of childbearing age.

18 Sep 2024

Drug-resistant SARS-CoV-2 variants found in immunocompromised patients

Individuals with compromised immunity and persistent COVID-19 infections can harbor drug-resistant variants of the SARS-CoV-2 virus, which have the potential to spread to the general population found researchers at Weill Cornell Medicine, the College of Veterinary Medicine at Cornell University and the National Institutes of Health's (NIH) National Institute of Allergy and Infectious Diseases (NIAID).

18 Sep 2024

Clinical trial finds pomalidomide effective for treating rare bleeding disorder

A clinical trial supported by the National Institutes of Health (NIH) was stopped early after researchers found sufficient evidence that a drug used to treat bone marrow cancer and Kaposi sarcoma is safe and effective in treating hereditary hemorrhagic telangiectasia (HHT), a rare bleeding disorder that affects 1 in 5,000 people worldwide.

18 Sep 2024

Efficacy News and Research

New study challenges dopamine's role in placebo effects and pain relief

Innovative HiTIP-seq method advances epigenetic research in pediatric brain tumors

Brain connectivity changes after psilocybin treatment in body dysmorphic disorder patients

Johnson & Johnson seeks first approval of nipocalimab to treat broadest population living with antibody positive generalized myasthenia gravis

Neuroactive drugs show promising anti-glioblastoma effects in preclinical trials

Research reveals disparities in diabetes drug efficacy for Black populations

Florida’s new covid booster guidance is straight-up misinformation

Triptans better at relieving migraine pain than recently marketed and more expensive drugs

Dietary antigens reduce small intestine cancer by boosting immune T-cells

AI-driven urban planning models mislead public health interventions, study shows

Promising antidepressant offers hope for glioblastoma treatment

Enhancing patient outcomes with AI-driven intratumoral immunotherapy

Study reveals biomarkers that predict disability worsening in multiple sclerosis

Researchers make strides in enhancing early diagnosis of bipolar disorder in adolescents

Phase 1 trial shows safety and efficacy of personalized vaccine for lymphoplasmacytic lymphoma

Multiple myeloma drug shows efficacy in treating rare bleeding disorder

Asimov launches AAV Edge, a suite of AI models, host cells, and genetic tools for end-to-end gene therapy development

Therapeutic inertia in the treatment of women with multiple sclerosis revealed

Drug-resistant SARS-CoV-2 variants found in immunocompromised patients

Clinical trial finds pomalidomide effective for treating rare bleeding disorder

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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