Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Study shines new light on the role of key Parkinson’s disease protein

One of the hallmarks of Parkinson's disease (PD) is the accumulation in the brain of a protein known as alpha-synuclein. For more than two decades, alpha-synuclein has been a focal point of attention for researchers, clinicians and drug makers interested in PD.

9 Jun 2022

Most synonymous genetic mutations are strongly harmful, study shows

In the early 1960s, University of Michigan alumnus Marshall Nirenberg and a few other scientists deciphered the genetic code of life, determining the rules by which information in DNA molecules is translated into proteins, the working parts of living cells.

8 Jun 2022

Research suggests two protein coding genes can predict severe COVID-19

In a recent study posted to the medRxiv* pre-print server, researchers demonstrated that two genes, GTPase, IMAP Family Member 7 (GIMAP7), and sphingosine-1-phosphate receptor 2 (S1PR2), have the potential to predict severe coronavirus disease 2019 (COVID-19) with ~90% accuracy.

8 Jun 2022

Immune protein could be a target of future treatments for alcohol use disorder

The anxiety that occurs during withdrawal from excessive alcohol use, and contributes to relapse, may be driven in part by the release of an immune protein in the brain, according to a new study from scientists at Scripps Research.

8 Jun 2022

Study identifies an epigenetic regulator that suppresses pathogenic events in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterized by chronic inflammation of synovium, eventually leading to joint destruction. Epigenetic alteration (the mechanism of gene expression regulation without DNA sequence changes), such as low levels of DNA methylation, is one of the factors which worsens the RA state.

8 Jun 2022

Novel approach to drug repurposing incorporates two-stage prediction and machine learning

A new study presents a novel approach to drug repurposing that incorporates two-stage prediction and machine learning.

7 Jun 2022

Sarbecovirus pathogenesis regulated by a multitrait locus

In a recent study posted to the bioRxiv* preprint server, the authors demonstrated that the sarbecovirus pathogenesis was regulated by a multitrait locus.

7 Jun 2022

MIT researchers identify components of mucus that can inhibit fungal infections

Candida albicans is a yeast that often lives in the human digestive tract and mouth, as well as urinary and reproductive organs.

6 Jun 2022

New analytical method sheds light on enduring mystery about type 2 diabetes

Researchers at Oregon State University have invented a new analytical method that sheds light on an enduring mystery regarding type 2 diabetes: Why some obese patients develop the disease and others don't.

6 Jun 2022

Combinations of multiple genetic factors play a role in the broad spectrum of autism

Autism Spectrum Disorder (ASD) is referred to as a "spectrum" because clinical features of ASD range from mild social impairments in some people to severe intellectual disability or epilepsy in others.

3 Jun 2022

Brain motor and fear circuits orchestrate the immune response to acute stress

A new study explores how acute stressors affected mice in terms of their immune responses in specific regions of the brain.

2 Jun 2022

A non-coding RNA molecule regulates mitochondrial gene expression in human cells, study shows

A new study published in the journal Cell shows that a non-coding RNA molecule regulates mitochondrial gene expression in human cells.

2 Jun 2022

Cellular changes in astrocytes play a crucial role in regulating outcomes for CNS disorders

Investigators at Cedars-Sinai have comprehensively mapped molecular activity in the brain and spinal cord that is responsible for regulating the body's response to central nervous system (CNS) disorders such as Alzheimer's, Huntington's disease and spinal cord injuries.

2 Jun 2022

New findings by HBP researchers provide a better understanding of human brain organization

Specific cellular, molecular and gene expression patterns in brain areas are linked to function, but their precise relationships remain largely unknown.

2 Jun 2022

Stem cell model could provide insights into biological mechanisms that underlie neuropsychiatric disorders

Researchers from the Icahn School of Medicine at Mount Sinai have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia.

1 Jun 2022

Microgravity culture during spaceflight enhances microbial infection process in 3D intestinal models

Infectious microbes have evolved sophisticated means to invade host cells, outwit the body's defenses and cause disease.

1 Jun 2022

People with food allergies less likely to become infected with SARS-CoV-2, study finds

A National Institutes of Health-funded study has found that people with food allergies are less likely to become infected with SARS-CoV-2, the virus that causes COVID-19, than people without them. In addition, while previous research identified obesity as a risk factor for severe COVID-19, the new study has identified obesity and high body mass index (BMI) as associated with increased risk for SARS-CoV-2 infection.

1 Jun 2022

Researchers identify molecular characteristics linked to increased likelihood of post-vaccination fatigue

Despite their strong effectiveness against SARS-CoV-2, mRNA-based COVID-19 vaccines are associated with adverse post-vaccination effects, such as fatigue; how can this be avoided? In a new study publishing May 31st in the open-access journal PLOS Biology, Ayesa Syenina of the Duke–NUS Medical School in Singapore and colleagues report that a new analysis of blood samples from people vaccinated for COVID-19 has identified distinct molecular characteristics linked to an increased likelihood of post-vaccination fatigue.

31 May 2022

IOB's new scRNA-seq protocol provides a snapshot of the cell transcriptome at unprecedented resolution

Single-cell RNA-sequencing (scRNA-seq) shows which genes are turned on in a cell and what their level of transcription is. This allows in-depth assessment of the biology of individual cells, and detection of changes that may indicate disease.

31 May 2022

UCLA researchers discover key molecular mechanism behind memory linking

Our brains rarely record single memories - instead, they store memories into groups so that the recollection of one significant memory triggers the recall of others connected by time.

25 May 2022

Gene Expression News and Research

Further Reading

Study shines new light on the role of key Parkinson’s disease protein

Most synonymous genetic mutations are strongly harmful, study shows

Research suggests two protein coding genes can predict severe COVID-19

Immune protein could be a target of future treatments for alcohol use disorder

Study identifies an epigenetic regulator that suppresses pathogenic events in rheumatoid arthritis

Novel approach to drug repurposing incorporates two-stage prediction and machine learning

Sarbecovirus pathogenesis regulated by a multitrait locus

MIT researchers identify components of mucus that can inhibit fungal infections

New analytical method sheds light on enduring mystery about type 2 diabetes

Combinations of multiple genetic factors play a role in the broad spectrum of autism

Brain motor and fear circuits orchestrate the immune response to acute stress

A non-coding RNA molecule regulates mitochondrial gene expression in human cells, study shows

Cellular changes in astrocytes play a crucial role in regulating outcomes for CNS disorders

New findings by HBP researchers provide a better understanding of human brain organization

Stem cell model could provide insights into biological mechanisms that underlie neuropsychiatric disorders

Microgravity culture during spaceflight enhances microbial infection process in 3D intestinal models

People with food allergies less likely to become infected with SARS-CoV-2, study finds

Researchers identify molecular characteristics linked to increased likelihood of post-vaccination fatigue

IOB's new scRNA-seq protocol provides a snapshot of the cell transcriptome at unprecedented resolution

UCLA researchers discover key molecular mechanism behind memory linking

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