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Study may provide insight into the evolution of D-amino acid function in marine invertebrates

Amino acids are the basic building blocks of living organisms and typically occur in a configuration known as the L-form. However, there are a few exceptional examples of the structural mirror image of the L-form (known as the D-form) being present in animals.

11 Mar 2022

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

Researchers investigated the effects of SARS-CoV-2 spike mutations on antiviral restriction mediated by interferon-induced transmembrane proteins and guanylate binding proteins.

11 Mar 2022

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

Study shows competitive fitness of emerging SARS-CoV-2 variants linked to their distinctiveness relative to identified lineages

Researchers defined a novel polynucleotide-based Distinctiveness metric to capture the proteome-level differences of emerging SARS-CoV-2 variants and lineages against all previously identified ones.

11 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation - the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

Researchers identify motor neuron toxin associated with ALS

An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) contributes to the motor neuron death that is the signature of these diseases.

10 Mar 2022

Origins and evolutions of SARS-CoV-2 Alpha variant in the UK

In a new study, researchers presented the origins and evolution of the SARS-CoV-2 lineage B.1.1.7 in the United Kingdom.

10 Mar 2022

Cross-species infectivity of SARS-CoV-2 variants correlated with prevalence

New research discusses the role of mutations in the receptor-binding domain of the spike protein in the generation of antibody resistance and loss of vaccine efficacy.

10 Mar 2022

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Researchers explored strategies to develop an mRNA-based COVID-19 vaccine that could elicit safer and wider protection against SARS-CoV-2 variants of concern.

10 Mar 2022

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

New research describes a novel approach whereby SARS-2 antigens were analyzed for conserved sites that may be targeted by broadly neutralizing antibodies that will confer immunity to other Sarbecoviruses.

10 Mar 2022

Researchers exploit cancer cells' appetite for iron to treat tough tumors

Researchers at the University of California, San Francisco, have successfully leveraged an FDA-approved drug to halt growth of tumors driven by mutations in the RAS gene, which are famously difficult to treat and account for about one in four cancer deaths.

9 Mar 2022

Assessment of oligonucleotides as COVID-19 treatment

A recent study posted to the bioRxiv* pre-print server assessed the ability of oligonucleotides in preventing the development of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions.

8 Mar 2022

A new view of SARS-CoV-2 genome structure

Researchers performed DMS mutational profiling with sequencing and DREEM clustering to determine the SARS-CoV-2 RNA secondary structure.

8 Mar 2022

How will mutations change the SARS-CoV-2 spike protein in the future?

A new Cells review discusses the factors that affect the function of the SARS-CoV-2 S protein and provides theoretical limits of this viral protein.

8 Mar 2022

Study reveals new insights on how immune system cells respond to disease-causing pathogens

In laboratory experiments involving a class of mutations in people with a rare collection of immune system disorders, Johns Hopkins Medicine researchers say they have uncovered new details about how immune system cells respond to disease-causing bacteria, fungi and viruses such as SARS-CoV-2.

8 Mar 2022

Mutation News and Research

Study may provide insight into the evolution of D-amino acid function in marine invertebrates

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Study shows competitive fitness of emerging SARS-CoV-2 variants linked to their distinctiveness relative to identified lineages

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers identify motor neuron toxin associated with ALS

Origins and evolutions of SARS-CoV-2 Alpha variant in the UK

Cross-species infectivity of SARS-CoV-2 variants correlated with prevalence

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

Researchers exploit cancer cells' appetite for iron to treat tough tumors

Assessment of oligonucleotides as COVID-19 treatment

A new view of SARS-CoV-2 genome structure

How will mutations change the SARS-CoV-2 spike protein in the future?

Study reveals new insights on how immune system cells respond to disease-causing pathogens

Study explores immune escape mutations caused by prolonged viral shedding in immunocompromised COVID-19 patient

Thermostable next-generation vaccine candidate against SARS-CoV-2 variants of concern studied in mice

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Recurrent mutations across the SARS-CoV-2 genome associated with long-term infections in immunodeficient patients

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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