Clinical Trial News and Research

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Smartphone-based behavioral therapy leads to improvements for patients with fibromyalgia

New research led by the University of Cincinnati and Swing Therapeutics found that a self-guided smartphone-based behavioral therapy led to significant improvements for patients with fibromyalgia.

8 Jul 2024

Real-world data confirms safety of RSV vaccination in late pregnancy

Vaccinating mothers against respiratory syncytial virus (RSV) during late pregnancy to protect their newborns is not associated with an increased risk of preterm birth or other poor outcomes, according to a study by Weill Cornell Medicine and NewYork-Presbyterian investigators.

8 Jul 2024

First-in-class oral drug improves embryo implantation and pregnancy outcomes in IVF

New research has demonstrated the effectiveness of a first-in-class oral, non-hormonal drug in increasing embryo implantation, pregnancy and live birth rates among infertile women who are undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

8 Jul 2024

Small molecule discovery offers hope for treatment of Angelman syndrome

Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities.

8 Jul 2024

Innovative hospice transition program boosts timely care for terminal patients

For patients who are in the final stages of both gradual and sudden terminal illnesses, hospice care can provide safe, comfortable, and dignified care at the end of life.

8 Jul 2024

Neuromuscular training reduces chemotherapy-induced neuropathy and improves patient outcomes

Researchers found that neuromuscular training significantly reduces the incidence and severity of chemotherapy-induced peripheral neuropathy, improving patient quality of life and treatment outcomes.

7 Jul 2024

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors.

5 Jul 2024

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

A major challenge in developing a vaccine for HIV is that the virus mutates fast - very fast. Although a person initially becomes infected with one or a few HIV strains, the virus replicates and mutates quickly, resulting in a "swarm" of viral strains existing in a single body.

2 Jul 2024

Financial incentives can improve smoking cessation among socioeconomically disadvantaged adults

A study published today by a University of Oklahoma researcher shows that financial incentives can make a big difference in helping smokers quit.

2 Jul 2024

Children consuming more isoflavones from soy foods exhibit better thinking abilities and attention

A new study found that school-aged children who consumed more isoflavones from soy foods exhibited better thinking abilities and attention.

2 Jul 2024

NIH launches Phase 1 trial for innovative nasal COVID-19 vaccine

A Phase 1 trial testing the safety of an experimental nasal vaccine that may provide enhanced breadth of protection against emerging variants of SARS-CoV-2, the virus that causes COVID-19, is now enrolling healthy adults at three sites in the United States.

1 Jul 2024

Strawberry fruit intake may improve glucose control and reduce CVD risk

Strawberries, America's favorite fruit, are top for consumers in taste, and research shows that they may be a good choice in promoting heart health as well.

1 Jul 2024

Simple exercises can prevent nerve damage during cancer treatments

Cancer treatments often cause nerve damage that can lead to long-lasting symptoms. Medication has proven ineffective in these cases.

1 Jul 2024

Efficacy of acupuncture in improving sleep quality for Parkinson's patients

Whether acupuncture improves sleep quality in Parkinson's patients.

1 Jul 2024

Innovative dementia cost model to aid families and shape health policy

An A-list of researchers from across USC is building a dementia cost model that will generate comprehensive national, annual estimates of the cost of dementia that could benefit patients and their families, thanks to a five-year, $8.2 million federal grant from the National Institute on Aging.

28 Jun 2024

Live biotherapeutic product can improve clinical outcomes for patients with kidney cancer

Physician scientists from City of Hope, one of the largest cancer research and treatment organizations in the United States, found that people with metastatic kidney cancer who orally took a live biotherapeutic product called CBM588 while in treatment with immunotherapy and enzymatic tyrosine kinase inhibitors experienced improved health outcomes.

28 Jun 2024

Gene therapy milestone at SickKids offers hope for children with SPG50 neurodegenerative disorder

When Michael Pirovolakis received an individualized gene therapy in a single-patient clinical trial at The Hospital for Sick Children (SickKids) in March 2022, the course of his condition was dramatically altered.

28 Jun 2024

Clinical trial seeks to evaluate safety of new EV-D68 treatment

The National Institutes of Health (NIH) is sponsoring a clinical trial to evaluate the safety of an investigational monoclonal antibody to treat enterovirus D68 (EV-D68), which can cause severe respiratory and neurological diseases such as acute flaccid myelitis (AFM) – similar to polio. Scientists are striving to better understand AFM, which has emerged in the United States with spikes in cases every other year, primarily in the late-summer months over the last decade.

28 Jun 2024

Antibody-drug conjugate effective, less toxic for stage 1 HER2+ breast cancer

A year of treatment with a medicine made of an antibody and chemotherapy drug has proven highly effective in preventing stage 1 HER2-positive breast cancer from recurring in patients, a team led by Dana-Farber Cancer Institute researchers has found.

28 Jun 2024

New study reveals how GLP-1 receptor agonists enhance preingestive fullness

GLP-1 receptor agonists promote the feeling of fullness before eating via neurons in the dorsomedial hypothalamus, according to a new study. The findings offer new insights into the neural pathways by which GLP-1 receptor agonists increase the feeling of fullness to prevent overconsumption of food, which is key in mitigating obesity. Glucagon-like-peptide-1 (GLP-1) plays an important role in signaling the feeling of fullness after eating.

27 Jun 2024

Clinical Trial News and Research

Smartphone-based behavioral therapy leads to improvements for patients with fibromyalgia

Real-world data confirms safety of RSV vaccination in late pregnancy

First-in-class oral drug improves embryo implantation and pregnancy outcomes in IVF

Small molecule discovery offers hope for treatment of Angelman syndrome

Innovative hospice transition program boosts timely care for terminal patients

Neuromuscular training reduces chemotherapy-induced neuropathy and improves patient outcomes

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

Financial incentives can improve smoking cessation among socioeconomically disadvantaged adults

Children consuming more isoflavones from soy foods exhibit better thinking abilities and attention

NIH launches Phase 1 trial for innovative nasal COVID-19 vaccine

Strawberry fruit intake may improve glucose control and reduce CVD risk

Simple exercises can prevent nerve damage during cancer treatments

Efficacy of acupuncture in improving sleep quality for Parkinson's patients

Innovative dementia cost model to aid families and shape health policy

Live biotherapeutic product can improve clinical outcomes for patients with kidney cancer

Gene therapy milestone at SickKids offers hope for children with SPG50 neurodegenerative disorder

Clinical trial seeks to evaluate safety of new EV-D68 treatment

Antibody-drug conjugate effective, less toxic for stage 1 HER2+ breast cancer

New study reveals how GLP-1 receptor agonists enhance preingestive fullness

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