Preclinical News and Research

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Discovery could lead to new mantle cell lymphoma drugs

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.

22 Nov 2022

Microniches of intratumoral microbiota impact spatial and cellular heterogeneity in cancer

Researchers mapped spatial, cellular, and molecular interactions of host and tumor-associated bacteria within the tumor microenvironment.

22 Nov 2022

Creating New Targeted Antibacterial Products to Help Tackle Antimicrobial Resistance

We speak to Matthew Dunne, Director for Drug Discovery at Micreos Pharmaceuticals, about the importance of creating new targeted antibacterial products.

22 Nov 2022

NIAID awards more than $12 million for the development of antiviral therapies

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, recently awarded more than $12 million to three institutions for the development of antiviral therapies to treat diseases caused by viruses with pandemic potential.

21 Nov 2022

CAR T-cell therapy in colorectal cancer

Researchers assessed the efficacy of CAR T-cells in the immunotherapy of colorectal cancer.

21 Nov 2022

Unusual Zika virus-specific antibody exhibits ultrapotent neutralization

An unusual type of antibody that even at miniscule levels neutralizes the Zika virus and renders the virus infection undetectable in preclinical models has been identified by a team led by Weill Cornell Medicine, NewYork-Presbyterian and National Institutes of Health (NIH) investigators.

20 Nov 2022

IESC transplant could repair the intestinal barrier after stroke and improve outcomes

Stroke is a leading cause of death, dementia and serious long-term disability. According to the American Heart Association, stroke patients also have a greater risk of depression, which negatively affects functional and cognitive recovery.

20 Nov 2022

Researchers uncover new therapeutic vulnerability in endocrine therapy-resistant breast cancers

For patients with estrogen receptor (ER)-positive breast cancer, development of the so-called Y537S mutation signals that their disease has taken an aggressive course and may become resistant to endocrine therapy.

20 Nov 2022

Pt(IV)-conjugated drug-delivery system shows efficacy in glioblastoma therapy

A recent study demonstrated a novel method for delivering anti-cancer drugs, conjugated to modified cell-penetrating peptides across the blood-brain barrier, in mice to treat glioblastoma.

18 Nov 2022

Bruker announces acquisition of Inscopix for neuroscience research

Bruker Corporation today announced the acquisition of Inscopix, Inc., a neuroscience pioneer and market leader of miniaturized microscopes, known as miniscopes, for freely moving animal brain imaging.

From Bruker Nano Surfaces and Metrology 16 Nov 2022

Research findings could bolster the effectiveness of immune-checkpoint therapy

Immune checkpoint inhibitors such as Keytruda and Opdivo work by unleashing the immune system's T cells to attack tumor cells.

16 Nov 2022

Researchers identify potential lead compounds for the treatment of neuropsychiatric disorders

Currently, various classes of drugs are available for the treatment of mental illnesses - such as depression and anxiety disorders. However, although these drugs confer benefits, they are also associated with adverse side-effects.

15 Nov 2022

Polyphenols in Mediterranean diet may modulate COVID-19 inflammation

Researchers discuss the beneficial role of polyphenolic plant compounds in the Mediterranean diet in the prevention and treatment of COVID-19.

15 Nov 2022

Behind the Scenes of the Oncology & Precision Medicine Conferences 2022

During the conference, we caught up with some of the speakers to learn more about their work, what they were presenting, and their thoughts about the future of Oncology and Precision Medicine.

15 Nov 2022

Hemagglutinin stem immunogens may hold the key for broad protection against influenza A viruses

Researchers proposed that vaccines targeting the immunosubdominant yet conserved hemagglutinin (HA) stem could trigger broadly neutralizing antibodies (bnAbs) against influenza A viruses.

15 Nov 2022

Cancer Research Horizons: The Innovation Engine of Cancer Research UK

Following ELRIG 2022, News-Medical speaks with Cancer Research Horizons, the innovation engine of Cancer Research UK about their efforts to advance the drug discovery sector.

From Cancer Research UK 14 Nov 2022

Researchers receive NIH grant to develop mRNA vaccines to deter cancer development

A multidisciplinary team of Weill Cornell Medicine researchers have received a five-year $5.7 million grant from the National Cancer Institute at the National Institutes of Health to fund a center aimed at developing messenger RNA (mRNA) vaccines to deter cancer development in at-risk groups.

11 Nov 2022

Research team identifies previously unknown ability of the autonomic nervous system

The autonomic nervous system is known as the control center for involuntary bodily processes such as the beating of our hearts and our breathing.

11 Nov 2022

Nanotechnology platform can make solid tumor cells more receptive to immunotherapy

A team of researchers at The University of Texas MD Anderson Cancer Center has developed a nanotechnology platform that can change the way the immune system sees solid tumor cells, making them more receptive to immunotherapy.

10 Nov 2022

Protein complex may present strong therapeutic target for lethal breast cancer

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that a protein complex that governs gene expression (called CoREST) sometimes gets rewired during breast cancer to help estrogen receptor positive (ER+) tumors resist endocrine therapies and become more aggressive.

8 Nov 2022

Preclinical News and Research

Discovery could lead to new mantle cell lymphoma drugs

Microniches of intratumoral microbiota impact spatial and cellular heterogeneity in cancer

Creating New Targeted Antibacterial Products to Help Tackle Antimicrobial Resistance

NIAID awards more than $12 million for the development of antiviral therapies

CAR T-cell therapy in colorectal cancer

Unusual Zika virus-specific antibody exhibits ultrapotent neutralization

IESC transplant could repair the intestinal barrier after stroke and improve outcomes

Researchers uncover new therapeutic vulnerability in endocrine therapy-resistant breast cancers

Pt(IV)-conjugated drug-delivery system shows efficacy in glioblastoma therapy

Bruker announces acquisition of Inscopix for neuroscience research

Research findings could bolster the effectiveness of immune-checkpoint therapy

Researchers identify potential lead compounds for the treatment of neuropsychiatric disorders

Polyphenols in Mediterranean diet may modulate COVID-19 inflammation

Behind the Scenes of the Oncology & Precision Medicine Conferences 2022

Hemagglutinin stem immunogens may hold the key for broad protection against influenza A viruses

Cancer Research Horizons: The Innovation Engine of Cancer Research UK

Researchers receive NIH grant to develop mRNA vaccines to deter cancer development

Research team identifies previously unknown ability of the autonomic nervous system

Nanotechnology platform can make solid tumor cells more receptive to immunotherapy

Protein complex may present strong therapeutic target for lethal breast cancer

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