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A protein found to be effective at reversing aging in skeletal muscle cells

A University at Buffalo-led research team has shown that a protein named for the mythical land of youth in Irish folklore is effective at reversing aging in skeletal muscle cells.

15 Sep 2021

Scientists develop a novel and potent SARS-CoV-2 RBD-homodimer vaccine

A recent report published in the journal Cell Discovery has described the immunogenicity and protective efficacy of a novel coronavirus disease 2019 (COVID-19) subunit vaccine candidate. The vaccine induces robust immune responses in rodents and non-human primates and protects the animals against severe disease.

12 Sep 2021

UGA research offers hope for a viable therapeutic to combat COVID-19

As COVID-19 cases continue to skyrocket across the U.S. and the world, few options are available for treating patients infected with the SARS-CoV-2.

11 Sep 2021

Nanoparticles-assisted delivery of antiviral-siRNA for treatment of COVID-19

A review aimed to determine the potential of siRNA as a potential COVID-19 treatment by reviewing the currently available literature.

10 Sep 2021

New gene-delivering workhorse could make gene therapy safer, more effective for muscle diseases

Genetic muscle diseases lead to progressive muscle wasting and often early death, with few treatment options and no cure.

9 Sep 2021

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

A new study successfully identifies a series of inhibitors that possesses pancoronavirus activity against SARS-CoV, SARS-CoV-2, and MERS-CoV.

7 Sep 2021

Study sheds light on neurologic symptoms caused by SARS-CoV-2 infection

Researchers in Australia and Finland have provided important insights into how infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – might affect nervous system circuitries and cause neurologic symptoms.

6 Sep 2021

Researchers develop the smallest CRISPR to date for genome editing

A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study publishing September 3 in the journal Molecular Cell.

4 Sep 2021

Antibody cocktail neutralizes SARS-CoV-2 and has projected protection up to 12 months

A new study reports long-lasting, effective protection against severe disease with the AZD7442 antibody cocktail.

3 Sep 2021

First-in-human trial proves feasibility of Temporally Feathered Radiation Therapy

Researchers from Cleveland Clinic and OhioHealth have published results from a first-in-human trial evaluating feasibility of Temporally Feathered Radiation Therapy (TFRT), which is designed to reduce the toxicity of radiation treatment.

1 Sep 2021

Impact of neoadjuvant concurrent chemoradiation on exosomal markers expression in colorectal cancer

Oncotarget published "The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma" which reported that the impact of neoadjuvant concurrent chemoradiation on exosomal markers expression and their prognostic significance in patients with rectal adenocarcinoma are yet to be explored.

1 Sep 2021

Defined & Controllable Extracellular Matrix for Cell Culture

Biochemically defined and animal-free - Mussel Adhesive Protein based matrix (MAPtrix™) from AMSBIO provides a highly defined and controllable recombinant extracellular matrix (ECM) for cell culture, which can be tailored to the specific needs of particular cell types.

From AMS Biotechnology 1 Sep 2021

New model shows how dysfunction in the air sacs initiates fibrotic cascade

Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of lung disease characterized by relentless scarring leading to death within an average of four years from the time of diagnosis.

31 Aug 2021

Attenuated virulence and protective immunity in SARS-CoV-2 with a mutation in the S1/S2 cleavage site

A new study published in mBio investigates the impact of the furin cleavage site on viral growth and pathogenesis.

31 Aug 2021

Research highlights the importance of meninges for brain development and pathology

A new study, led by researchers at the University of Gothenburg, have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes, under normal conditions and after perinatal brain injury.

31 Aug 2021

Novel coating technology increases lifespan and stability of implantable devices

Various human implantable medical devices have been developed in recent years, and they are being used in clinical filed. These devices include brain–machine interfaces, in which a chip is implanted into the brain to enable humans to move machines using only their thoughts, and deep brain stimulators for treating Parkinson's disease and other brain diseases.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Self-amplifying RNA (saRNA) is an advanced platform for nucleic acid vaccine development. The backbone is typically derived from an alphaviral genome and encodes a gene of interest (GOI) and a viral replicase that can amplify the genomic and subgenomic RNA.

30 Aug 2021

Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

Oncotarget published "Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis" which reported that microscopic imaging, immunocytochemistry, wound healing assay, caspase-cleaved cytokeratin 18 CytoDeath ELISA assay, immunofluorescence labeling assays for apoptosis, hypoxia, Western Blotting, Tunnel assay, measurement of 5-HT secretion by carbon fiber amperometry assay, quantitative methylation-specific PCR, morphologic changes, cell viability, apoptosis activity and the expression levels of phospho-Akt1, Akt1, HIF-1α, PI3K, p21, CAIX, 5-HT, phospho-mTOR, and mTOR in xenografts derived from typical H727 and atypical H720 BC cell lines.

28 Aug 2021

Ultrasound-based technology for measuring brain pressure could replace surgery

A new invention may be on the verge of replacing a costly cranial surgical procedure currently being performed on some traffic accident victims and other patient groups. The ultrasound-based technology has now been granted CE approval for the European market.

28 Aug 2021

in vivo News and Research

A protein found to be effective at reversing aging in skeletal muscle cells

Scientists develop a novel and potent SARS-CoV-2 RBD-homodimer vaccine

UGA research offers hope for a viable therapeutic to combat COVID-19

Nanoparticles-assisted delivery of antiviral-siRNA for treatment of COVID-19

New gene-delivering workhorse could make gene therapy safer, more effective for muscle diseases

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

Study sheds light on neurologic symptoms caused by SARS-CoV-2 infection

Researchers develop the smallest CRISPR to date for genome editing

Antibody cocktail neutralizes SARS-CoV-2 and has projected protection up to 12 months

First-in-human trial proves feasibility of Temporally Feathered Radiation Therapy

Impact of neoadjuvant concurrent chemoradiation on exosomal markers expression in colorectal cancer

Defined & Controllable Extracellular Matrix for Cell Culture

New model shows how dysfunction in the air sacs initiates fibrotic cascade

Attenuated virulence and protective immunity in SARS-CoV-2 with a mutation in the S1/S2 cleavage site

Research highlights the importance of meninges for brain development and pathology

Novel coating technology increases lifespan and stability of implantable devices

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

Ultrasound-based technology for measuring brain pressure could replace surgery

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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