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Functionality testing in the pharmaceutical and medical sectors

In this interview, News-Medical talks to ZwickRoell UK about materials testing in the pharmaceutical and medical industry.

7 Oct 2021

Massage can enhance healing and strength of muscles, study finds

Massage has been used to treat sore, injured muscles for more than 3,000 years, and today many athletes swear by massage guns to rehabilitate their bodies. But other than making people feel good, do these "mechanotherapies" actually improve healing after a severe injury? According to a new study from researchers at Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences (SEAS), the answer is "yes."

7 Oct 2021

First of its kind ‘living medicine’ designed to treat antibiotic-resistant bacteria on medical implants

Researchers at the Centre for Genomic Regulation and Pulmobiotics S.L have created the first 'living medicine' to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. The researchers created the treatment by removing a common bacteria's ability to cause disease and repurposing it to attack harmful microbes instead.

6 Oct 2021

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

In a recent study published in CANCER RESEARCH , a team led by researchers at Tokyo Medical and Dental University (TMDU) identified a specific small RNA molecule, called a microRNA (miRNA or miR), that has the potential to be used as an anti-cancer therapeutic.

5 Oct 2021

Researchers develop new method to predict biomaterial's capacity to induce tissue regeneration

Researchers from the Polymer and Advanced Materials Group at the Universitat Jaume I in Castellón have developed an in vitro method to predict the capacity of a biomaterial to induce bone and soft tissue regeneration.

5 Oct 2021

REGEN-COV shown to reduce risk of COVID-19–related hospitalization or death from any cause

The phase 1-2 clinical trials conducted using REGEN-COV had shown promising therapeutic benefits in COVID-19 outpatients. Its effect was further investigated in the present phase 3 clinical trial, the findings of which have been published in the "The New England Journal of Medicine".

3 Oct 2021

Early-stage interaction of monocytes with SARS-CoV-2-infected epithelial cell decides COVID-19 severity

A team of scientists from the USA and France has recently unveiled the mechanism of immune dysregulation in coronavirus disease 2019 (COVID-19) patients by analyzing the early-stage interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected epithelial cells and immune cells. The study is currently available on the bioRxiv* preprint server.

30 Sep 2021

New drug combination effectively suppresses SARS-CoV-2 infection

More countries with greater resources are opening up for a more normal life. But COVID-19 and the SARS-CoV-2 virus are still a significant threat in large parts of the world.

30 Sep 2021

New system synthetically reconnects neural circuits using neuropeptides from Hydra

For two people to communicate in a loud, crowded room, they need to be standing side by side. The same is often true for neurons in the brain. But the same way a cell phone allows two people to communicate clearly across the room, new research at the Marine Biological Laboratory (MBL) opened up a new channel of communication in the worm C. elegans brain.

30 Sep 2021

Scientists describe SARS-CoV-2 uptake in tissue-resident human macrophages enhanced by virus-specific antibodies

Now, in a new news study posted to the bioRxiv* preprint server, researchers have successfully induced similar chronicity associated with SARS-CoV-2 infection in MISTRG6-hACE2 humanized mice.

29 Sep 2021

Novel small-molecule therapy shows promise against deadly pediatric leukemia

Mount Sinai researchers have developed a therapy that shows promise against a deadly pediatric leukemia. The small-molecule therapy was highly effective in fighting a type of acute myeloid leukemia in both in vitro and in vivo experiments, according to research published in Science Translational Medicine in September.

29 Sep 2021

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with SARS-CoV-2 infection.

28 Sep 2021

Scientists identify potential antibody candidate with broad-spectrum neutralizing efficacy against SARS-CoV-2 variants

A team of scientists from China and the USA has recently described the antiviral efficacy of a monoclonal antibody candidate targeting the spike receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Importantly, they have observed that emerging spike mutations could not affect the potency of this antibody. The study is currently available on the bioRxiv* preprint server.

27 Sep 2021

Scientists discover novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

A new type of targeting chaperon protein HSP70 inhibitor QL47 was recently discovered by a team led by Prof. LIU Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences to treat FLT3-ITD-positive acute myeloid leukemia (AML).

27 Sep 2021

Study reveals surfaces of SARS-CoV-2 spike most resistant to antibody escape

A team of international scientists has formed a consortium to map the epitope landscape of a range of therapeutic monoclonal antibodies on the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, the scientists characterized the neutralization potency of these antibodies and have investigated how emerging viral variants with spike mutations can impact antibody-mediated neutralization. They have recently published the consortium findings in the journal Science.

27 Sep 2021

New simple plasmonic optical fiber biosensing platform for detecting estrogenic endocrine disruptors

Developing the advanced and powerful detection techniques to characterize as many endocrine disruptors as possible with ultra-sensitivity in the environment is still challenging, however highly demanded.

25 Sep 2021

New 3D pancreatic cancer model could be used to develop and test targeted treatments

An international team of scientists have created a three-dimensional (3D) pancreatic cancer tumour model in the laboratory, combining a bioengineered matrix and patient-derived cells that could be used to develop and test targeted treatments.

24 Sep 2021

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress response pathway that promotes survival of cancer cells, which become sensitive to pharmacological inhibition of this pathway. These findings were published online in Cancer Research, a journal of the American Association for Cancer Research, and point to a new therapeutic opportunity for this type of ovarian cancer for which new solutions are urgently needed.

22 Sep 2021

Researchers uncover a molecular mechanism to inhibit aggravation of colitis

The intestinal microbial ecosystem includes diverse species of bacteria. These bacteria can produce bioactive metabolites that directly affect the host's immune system.

21 Sep 2021

Role of extracellular vesicles embedded with engineered ACE2 in the neutralization of the SARS-CoV-2 pseudovirus

Researchers discuss the preparation and characterization of EVs-ACE2, along with the production and characterization of SARS-CoV-2 S-pseudovirus.

20 Sep 2021

in vivo News and Research

Functionality testing in the pharmaceutical and medical sectors

Massage can enhance healing and strength of muscles, study finds

First of its kind ‘living medicine’ designed to treat antibiotic-resistant bacteria on medical implants

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

Researchers develop new method to predict biomaterial's capacity to induce tissue regeneration

REGEN-COV shown to reduce risk of COVID-19–related hospitalization or death from any cause

Early-stage interaction of monocytes with SARS-CoV-2-infected epithelial cell decides COVID-19 severity

New drug combination effectively suppresses SARS-CoV-2 infection

New system synthetically reconnects neural circuits using neuropeptides from Hydra

Scientists describe SARS-CoV-2 uptake in tissue-resident human macrophages enhanced by virus-specific antibodies

Novel small-molecule therapy shows promise against deadly pediatric leukemia

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

Scientists identify potential antibody candidate with broad-spectrum neutralizing efficacy against SARS-CoV-2 variants

Scientists discover novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

Study reveals surfaces of SARS-CoV-2 spike most resistant to antibody escape

New simple plasmonic optical fiber biosensing platform for detecting estrogenic endocrine disruptors

New 3D pancreatic cancer model could be used to develop and test targeted treatments

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Researchers uncover a molecular mechanism to inhibit aggravation of colitis

Role of extracellular vesicles embedded with engineered ACE2 in the neutralization of the SARS-CoV-2 pseudovirus

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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