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First molecular movie captures DNA unzipping at atomic level

Scientists at the University of Leicester have captured the first detailed "molecular movie" showing DNA being unzipped at the atomic level – revealing how cells begin the crucial process of copying their genetic material.

21 Mar 2025

Study reveals the structural underpinnings of memory formation in the mouse brain

In a study supported by the National Institutes of Health (NIH), researchers revealed the structural underpinnings of memory formation across a broad network of neurons in the mouse brain.

20 Mar 2025

Breakthrough study unveils mechanics of DNA unwinding

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life.

19 Mar 2025

Researchers challenge the genetic paradigm of cancer

It's time for researchers to reconsider the current paradigm of cancer as a genetic disease, argued Sui Huang from the Institute for Systems Biology, USA, and colleagues in a new essay published March 18th in the open-access journal PLOS Biology.

19 Mar 2025

Breakthrough peptide inhibitor effective against multiple SARS-CoV-2 variants

SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 (ACE2) receptors.

14 Mar 2025

Scientists uncover structure of key enzyme to block cancer cell energy supply

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells hijack various cellular functions to find and exploit energy and other resources, including a group of enzymes that help normal cells maintain a balance of energy.

6 Mar 2025

Breakthrough study sheds light on Pol-theta’s role in DNA repair and cancer

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these proteins-called polymerase theta (Pol-theta)-for their own survival.

4 Mar 2025

Scientists develop fenugreek-based nanoparticles to enhance diabetes drug effectiveness

Researchers explored L-arginine-loaded lipid nanoparticles from fenugreek seed oil, finding they enhance drug stability and bioavailability, showing promise for diabetes treatment.

2 Mar 2025

Scientists uncover how a sugar shield in brain blood vessels protects against aging and disease

Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain barrier, leading to increased permeability, neuroinflammation, and cognitive decline in aging and neurodegenerative diseases.

27 Feb 2025

New AI model revolutionizes cell structure segmentation in microscopy

Identifying and delineating cell structures in microscopy images is crucial for understanding the complex processes of life.

26 Feb 2025

Breakthrough computational tool enhances design of targeted antiviral therapies

Viruses, like those that cause COVID-19 or HIV, are formidable opponents once they invade our bodies. Antiviral treatments strive to block a virus or halt its replication.

17 Feb 2025

Harvard researchers map 70,000 synaptic connections in rat brain

Harvard researchers have mapped and catalogued more than 70,000 synaptic connections from about 2,000 rat neurons, using a silicon chip capable of recording small yet telltale synaptic signals from a large number of neurons.

14 Feb 2025

EMBL researchers reveal new structural insights into minor spliceosome function

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome continuously separates the coding and non-coding regions of our genes – and it's doing this even as you read these lines.

12 Feb 2025

Novel biomarker for early prevention of Alzheimer’s disease

New serine biomarkers show promise for early Alzheimer's detection, linking tau assemblies to cognitive decline and offering potential for timely intervention.

11 Feb 2025

New discovery links brain and muscle cells in signal transmission

Our biceps and our brain cells may have more in common than previously thought.

8 Feb 2025

Collagen's structural diversity may be greater than previously believed, study suggests

Collagen, the body's most abundant protein, has long been viewed as a predictable structural component of tissues.

7 Feb 2025

Research disproves persister bacteria as main cause of antibiotic resistance

Antibiotics are indispensable for treating bacterial infections. But why are they sometimes ineffective, even when the bacteria are not resistant? In their latest study published in the journal Nature, researchers from the University of Basel challenge the conventional view that a small subset of particularly resilient bacteria are responsible for the failure of antibiotic therapies.

5 Feb 2025