Genomic Sequencing News and Research

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Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

It's not often that a failed clinical trial leads to a scientific breakthrough. When patients in the UK started showing adverse side effects during a cancer immunotherapy trial, researchers at La Jolla Institute for Immunology (LJI) Center for Cancer Immunotherapy and University of Liverpool went back through the data and worked with patient samples to see what went wrong.

5 May 2022

The war against COVID-19: reinfection, vaccines, and herd immunity

A communication published in the journal Epidemiologia aimed to answer several questions concerning neutralizing antibodies against SARS-CoV-2, herd immunity, and COVID-19 vaccines.

4 May 2022

Epidemiologic and genomic investigation of SARS-CoV-2 infections associated with two repatriation flights from India to Australia

Researchers conducted epidemiologic and genomic studies to investigate in-flight SARS-CoV-2 infection associated with repatriation flights from India to Australia in April 2021.

3 May 2022

Study evaluates hybridization probe capture for enriching coronavirus genomic material in bat oral and rectal swabs

Researchers surveilled coronaviruses found in bats via targeted genomic sequencing.

29 Apr 2022

Tech Titans want the richest Californians to pay for pandemic preparedness

Gabe Bankman-Fried, a former Wall Street trader, has raised $12 million from a cryptocurrency trading firm founded by his brother, Sam Bankman-Fried.

26 Apr 2022

Continual genomic surveillance in Africa provides insights into evolving SARS-CoV-2 pandemic

Researchers described how SARS-CoV-2 genomic sequencing efforts in Africa helped identify two of the five SARS-CoV-2 VOCs, and their early analysis.

22 Apr 2022

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

A variant of the CTLA-4 gene associated with autoimmune disease was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in a comparable cohort of lung cancer patients and healthy individuals, according to data presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

The dynamics of the Omicron wave in England

Researchers investigated the transmission dynamics of SARS-CoV-2 VOC Omicron in England using PCR testing and genomic sequencing data from the REACT-1 study.

7 Apr 2022

SARS-CoV-2 transmission from human to free-roaming dogs during a severe COVID-19 outbreak in the Amazonian Region of Ecuador

A new study shows how free-roaming village dogs in an Ecuadorian village within the Amazon jungle have been infected with the virus, presumably by the human hosts.

6 Apr 2022

Pre-existing memory B cell dynamics during SARS-CoV-2 Omicron breakthrough infection

A new study analyzed the recall of pre-existent cross-reactive memory B cells upon the SARS-CoV-2 Omicron breakthrough infections.

5 Apr 2022

Air surveillance of SARS-CoV-2 and other respiratory pathogens

A recent study posted to the medRxiv* preprint server reported severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) detection in air samples from real-world congregate settings.

4 Apr 2022

The longest duration of SARS-CoV-2 positivity after initial diagnosis

An immunocompetent individual with prolonged SARS-CoV-2 shedding 221 days after their initial COVID-19 diagnosis.

31 Mar 2022

UIC researchers projected to receive $22 million to study long COVID-19

A team of University of Illinois Chicago researchers is projected to receive approximately $22 million from the National Institutes of Health over four years to research long COVID-19.

31 Mar 2022

Study describes the identification of a SARS-CoV-2 variant that escapes detection by antigen tests

Researchers raised concerns that some SARS-CoV-2 variants can escape detection by antigen tests.

30 Mar 2022

Study investigates whether coinfection with multiple SARS-CoV-2 variants exists in COVID-19 patients

A new study shows that multiple variants of this virus may coinfect the same patient, using both genomic sequencing data and computational models.

30 Mar 2022

Understanding a New Mutation in Pediatric AML

News-Medical speaks to Dr. Jeffery Klco about acute myeloid leukemia (AML) and his recent research that is helping us to understand a new mutation in pediatric AML.

25 Mar 2022

Genomic sequencing reveals unique pattern of SARS-CoV-2 Epsilon emergence in Alaska

Researchers used genomic sequencing to examine SARS-CoV-2 genomes from Alaska, United States, between December 2020 and June 2021.

23 Mar 2022

Mayo Clinic researchers report differences in genomic data quality among racial groups

Mayo Clinic researchers studied the differences in genomic data quality among racial groups in one of the largest and most widely used cancer research datasets, The Cancer Genome Atlas.

17 Mar 2022

Study suggests single nucleotide polymorphism in interferon receptor impacts COVID-19 outcomes

Researchers reported the association of a single nucleotide polymorphism rs9984273 in the interferon-alpha/beta receptor gene with outcomes of acute respiratory distress syndrome and COVID-19.

17 Mar 2022

The effects of anti-SARS-CoV-2 monoclonal antibodies on pregnant and postpartum women

Researchers examine the safety and efficacy of mAbs in pregnant and postpartum women with COVID-19.

16 Mar 2022