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Novel gene therapy holds potential in treating patients with epilepsy

Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) are working on a therapy that holds potential in treating patients with epilepsy, a neurological disorder defined by recurring seizures due to abnormal brain activity.

9 Oct 2024

Exploring the venomous potential of marine crustaceans for drug development

Many animals use venoms for self-defense or hunting. The components of such venom, known as toxins, interfere with various physiological processes - which is also the reason why they are so interesting for the development of new pharmacological agents.

4 Oct 2024

Study identifies a new target for developing atrial fibrillation therapy

A new study by researchers at the University of Arizona College of Medicine – Phoenix and the University of California Davis Health identified a new target for developing a therapy to treat atrial fibrillation, the most common type of abnormal heart rhythm.

4 Oct 2024

New X-ray technique reveals metal ion role in antibiotic efficacy

Researchers from City St George's, University of London have used a new ultra-high precision x-ray scattering technique to unveil the location and identity of metal ions in bacteria that are crucial for antibiotics to work optimally.

4 Oct 2024

A randomized trial of mexiletine and lamotrigine in adults with non-dystrophic myotonia

The study, published in Lancet Neurology, detailed the "head-to-head" trial implemented by the researchers to test two drugs, mexiletine and lamotrigine, on people with the condition.

27 Sep 2024

Why hypoglycemia-induced glucagon secretion becomes impaired in diabetes

Findings indicate that excessive somatostatin inhibits glucagon secretion in type 1 diabetes, offering a novel target for hypoglycemia management strategies.

27 Sep 2024

Calcium channel blockers show potential to restore cerebral blood flow in Alzheimer's disease

Targeting calcium channels in pericytes may improve blood flow in Alzheimer's disease, addressing early vascular dysfunction linked to cognitive deficits.

23 Sep 2024

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity and metabolic disease treatment.

19 Sep 2024

Study paves way for revolutionizing the management of muscle disorders

The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction.

18 Sep 2024

Salt can boost antitumor responses of T cells

Elevated sodium levels in tumors boost T-cell metabolic fitness and cytotoxicity, revealing potential avenues for improving cancer therapies.

13 Sep 2024

Heatwaves linked to increased seizures in epilepsy patients

Heatwaves can worsen abnormal excitability of the brain in people with epilepsy, finds a new small-scale patient study by clinical scientists at UCL.

11 Sep 2024

Electric current in gut attracts pathogens like Salmonella

Salmonella typhimurium's infection mechanism involves gut bioelectric signals, influencing its localization and interactions within the intestinal environment.

5 Sep 2024

Novel intermediate form of serotonin receptor identified as therapeutic target for psychiatric disorders

Misha Kudryshev's lab at the Max Delbrück Center has identified a molecular intermediate of a serotonin receptor that is involved in diseases such as depression and schizophrenia.

4 Sep 2024

Understanding gluten's role in autoimmunity and inflammation

The interaction between humans and their environment, mediated by nutrition, plays a crucial role in regulating inflammatory responses.

21 Aug 2024

Study identifies natural molecule that reduces pain sensitivity

Rutgers researchers have found a new way to manage the receptors that control the sense of touch, which could lead to treating chronic pain more effectively.

21 Aug 2024

Greater plant fat intake associated with lower overall and cardiovascular disease mortality

Researchers determined the relationship between animal and dietary plant fat intake with mortality from cardiovascular disease (CVD) and other causes.

13 Aug 2024

Human dopamine transporter structure with cocaine revealed, unlocking addiction insights

Researchers have resolved the high-resolution structure of the human dopamine transporter bound to cocaine, providing critical insights into the molecular basis of cocaine's addictive properties.

12 Aug 2024

ATP regulation in ClC-3 exchangers linked to neurodegenerative diseases, study reveals

Researchers structurally analyzed adenine nucleotide control and neurodegenerative diseases in ClC-3 exchangers.

11 Aug 2024

Electrically powered artificial muscle fibers: Emerging power source for robotics and wearable devices

In the dynamic landscape of intelligent technology, electrically powered artificial muscle fibers (EAMFs) are emerging as a revolutionary power source for advanced robotics and wearable devices.

2 Aug 2024

Study provides novel insights into the molecular mechanisms of melanoma progression

Cong Peng et al., at Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled "NETO2 promotes melanoma progression via activation of the Ca²⁺/CaMKII signaling pathway" that investigates the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.

2 Aug 2024

Ion News and Research

Novel gene therapy holds potential in treating patients with epilepsy

Exploring the venomous potential of marine crustaceans for drug development

Study identifies a new target for developing atrial fibrillation therapy

New X-ray technique reveals metal ion role in antibiotic efficacy

A randomized trial of mexiletine and lamotrigine in adults with non-dystrophic myotonia

Why hypoglycemia-induced glucagon secretion becomes impaired in diabetes

Calcium channel blockers show potential to restore cerebral blood flow in Alzheimer's disease

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Study paves way for revolutionizing the management of muscle disorders

Salt can boost antitumor responses of T cells

Heatwaves linked to increased seizures in epilepsy patients

Electric current in gut attracts pathogens like Salmonella

Novel intermediate form of serotonin receptor identified as therapeutic target for psychiatric disorders

Understanding gluten's role in autoimmunity and inflammation

Study identifies natural molecule that reduces pain sensitivity

Greater plant fat intake associated with lower overall and cardiovascular disease mortality

Human dopamine transporter structure with cocaine revealed, unlocking addiction insights

ATP regulation in ClC-3 exchangers linked to neurodegenerative diseases, study reveals

Electrically powered artificial muscle fibers: Emerging power source for robotics and wearable devices

Study provides novel insights into the molecular mechanisms of melanoma progression

Enhancing confidence in chemical ionization spectrometry data eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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