Lupus Erythematosus News and Research

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Researchers find possible cause for self-destructive immune system attacks in autoimmune diseases

Autoimmune diseases, in which the body's own immune system attacks healthy tissue, can be life-threatening and can impact all organs.

2 Feb 2021

Systemic lupus erythematosus disproportionately affects ethnic female population

Just over 200,000 Americans suffer from systemic lupus erythematosus, or SLE, a condition in which the body's immune system mistakenly attacks its own healthy tissues, especially joints and skin, a new study shows.

21 Jan 2021

Study shows that risk of autoimmune disease lupus is higher in females

The US prevalence of the autoimmune disease lupus is 72.8 cases per 100,000 individuals, according to an analysis of population-based registries.

21 Jan 2021

Common gene expression changes at target tissues of four autoimmune diseases found

Autoimmune diseases are diseases of "mistaken identity", where the immune system - which is supposed to protect us against infectious diseases and neoplasias - mistakenly attacks and destroys components of our own body.

7 Jan 2021

New approach can help identify novel treatments for autoimmune diseases

A team of researchers led by the Indiana Biosciences Research Institute Diabetes Center's Scientific Director Decio L. Eizirik, MD, PhD, has found that identifying new treatments for autoimmune diseases requires studying together the immune system AND target tissues.

7 Jan 2021

TTUHSC professor receives 2020 Lupus Mechanisms and Targets Award

The Lupus Research Alliance recently named R. Bryan Sutton, Ph.D., a professor in the Department of Cell Physiology and Molecular Biophysics at the Texas Tech University Health Sciences Center, as a recipient of a 2020 Lupus Mechanisms and Targets Award.

3 Dec 2020

Steroids used to treat inflammatory disease increases risk of cardiovascular disease

Researchers have found that prescribed low doses of steroids, often to combat inflammatory diseases, are at an increased risk of cardiovascular diseases.

3 Dec 2020

Research provides deeper insight into the pathogenesis of sclerodermatous chronic GVHD

Occasionally, following a transplant procedure, the donor's immune cells recognize the recipient's tissues as foreign and trigger a multisystem disorder called graft-versus-host disease (GVHD).

2 Dec 2020

Mymee's clinical trial demonstrates health-related quality of life improvements in lupus patients

Mymee Inc., the leading digital health company that empowers those who suffer from autoimmune disease to reclaim their health, today announced the publication of it’s study assessing the Mymee Program as adjunct care in patients with Systemic Lupus Erythematosus in the Journal of Medical Internet Research .

9 Nov 2020

Study: Hydroxychloroquine has no effect on abnormal heart rhythm in lupus patients with CKD

New research shows that adults with lupus who take the antimalarial drug, hydroxychloroquine, do not have any differences in their corrected QT (QTc) intervals, an electrocardiogram (EKG) measurement of the heart's electrical signals, even if they have chronic kidney disease (CKD), a complication of lupus that can be associated with increased levels of the medication.

9 Nov 2020

Black patients with lupus have higher risk of stroke and ischemic heart disease

New research reveals that, in the U.S., Black patients with lupus have a threefold higher risk of stroke and a 24-fold higher risk of ischemic heart disease.

6 Nov 2020

Lupus patients receiving prophylactic therapy are at high risk for adverse reactions

New research shows that adults with systemic lupus erythematosus, who receive trimethoprim-sulfamethoxazole (TMP-SMX), a prophylactic therapy to help prevent pneumocystis pneumonia, are at high risk for adverse reactions to the drug, particularly if they are also positive for anti-Smith (anti-Sm) antibodies.

6 Nov 2020

Patients with rheumatic diseases reported antimalarial drug shortages during COVID-19

A new study shows that patients with rheumatic diseases across Africa, Southeast Asia, the Americas and Europe had trouble filling their prescriptions of antimalarial drugs, including hydroxychloroquine, during the 2020 global coronavirus pandemic, when antimalarials were touted as a possible COVID-19 treatment.

6 Nov 2020

Hydroxychloroquine not associated with prolonged heart rhythm intervals in RA or lupus patients

New research presented at ACR Convergence, the American College of Rheumatology's annual meeting, discovers that use of hydroxychloroquine, a generic drug, does not cause any significant differences in QTc length or prolonged QTc, key measures of heart rate, in people with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE).

6 Nov 2020

Pre-existing anti-IFN autoantibodies may worsen COVID-19 in lupus patients

“Our observations suggest that the presence of these autoantibodies may predispose SLE patients to infection with SARS-CoV-2 with a more severe presentation and represent an additional risk factor in this patient population,” write Sarthak Gupta and colleagues from the National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, Maryland.

5 Nov 2020

Lung biomarkers may predict severe COVID-19

Two University of New Mexico researchers postulate certain specific biomarkers' relevance in predicting the potential for progression to severe COVID-19 in a paper published on the preprint server bioRxiv*

27 Oct 2020

Exuberant activation of immune cells in severe COVID-19 resembles lupus

In severe cases of COVID-19, Emory researchers have been observing an exuberant activation of immune cells, resembling acute flares of systemic lupus erythematosus (SLE), an autoimmune disease.

9 Oct 2020

Auto-antibodies may explain why some people develop severe COVID-19

Now, a new study by an international team of health experts shows that some life-threatening cases of COVID-19 can be traced to specific weak spots in the patients' immune system.

28 Sep 2020

Targeted treatment for systemic lupus erythematosus

A team of researchers from Charité - Universitätsmedizin Berlin and the Deutsches Rheuma-Forschungszentrum Berlin, a Leibniz Institute, have successfully treated two patients with the autoimmune disease systemic lupus erythematosus.

22 Sep 2020

Memory B cells indicate durable immunity in COVID-19

Now a new study by researchers at SUNY Upstate Medical University and published recently on the preprint server medRxiv in September 2020 shows that memory B cells are upregulated in convalescent COVID-19 patients, correlating with a better immune response and shorter symptom duration.

8 Sep 2020

Lupus Erythematosus News and Research

Researchers find possible cause for self-destructive immune system attacks in autoimmune diseases

Systemic lupus erythematosus disproportionately affects ethnic female population

Study shows that risk of autoimmune disease lupus is higher in females

Common gene expression changes at target tissues of four autoimmune diseases found

New approach can help identify novel treatments for autoimmune diseases

TTUHSC professor receives 2020 Lupus Mechanisms and Targets Award

Steroids used to treat inflammatory disease increases risk of cardiovascular disease

Research provides deeper insight into the pathogenesis of sclerodermatous chronic GVHD

Mymee's clinical trial demonstrates health-related quality of life improvements in lupus patients

Study: Hydroxychloroquine has no effect on abnormal heart rhythm in lupus patients with CKD

Black patients with lupus have higher risk of stroke and ischemic heart disease

Lupus patients receiving prophylactic therapy are at high risk for adverse reactions

Patients with rheumatic diseases reported antimalarial drug shortages during COVID-19

Hydroxychloroquine not associated with prolonged heart rhythm intervals in RA or lupus patients

Pre-existing anti-IFN autoantibodies may worsen COVID-19 in lupus patients

Lung biomarkers may predict severe COVID-19

Exuberant activation of immune cells in severe COVID-19 resembles lupus

Auto-antibodies may explain why some people develop severe COVID-19

Targeted treatment for systemic lupus erythematosus

Memory B cells indicate durable immunity in COVID-19

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