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Precision nano therapy targets tumor nerves in pancreatic cancer

Announcing a new publication for Acta Materia Medica journal. A preclinical study has developed a precision nano-intervention strategy targeting tumor-associated nerves to destroy nerve-fueled tumor growth in pancreatic cancer.

8 May 2025

Natural compound fisetin protects blood vessels from hardening

A new research paper was published in Aging (Aging-US) Volume 17, Issue 4, on April 2, 2025, titled "Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibition."

6 May 2025

HO-1 regulates liver fibrosis in NAFLD through the SIRT1 TGF-β Smad3 pathway

Heme oxygenase 1 (HO-1) has an influential yet insufficiently investigated effect on Sirtuin 1 (SIRT1), a histone deacetylase activated by nicotinamide adenine dinucleotide, which may impact the transforming growth factor-β (TGF-ß)/Smad3 pathway in nonalcoholic fatty liver disease (NAFLD)-related liver fibrosis.

2 May 2025

Study links pregnancy specific genes to poorer lung cancer outcomes in women

Lung cancer can co-opt genes that normally help a fetus develop and evade the mother's immune system. And while these pregnancy-specific glycoproteins (PSGs) can get activated in the cancers of both men and women, female patients had poorer outcomes, a Memorial Sloan Kettering Cancer Center (MSK) research team has found.

29 Apr 2025

New topical gel reduces painful rash from colorectal cancer treatment

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center and The University of Texas MD Anderson Cancer Center have demonstrated that a novel topical BRAF inhibitor gel called LUT014 significantly reduces the severity of an acne-like rash, a common and painful side effect experienced by patients undergoing anti-EGFR therapies for colorectal cancer.

28 Apr 2025

How immune resilience and salutogenesis promote disease resistance and longevity

Researchers examine how salutogenesis, the active production of health through immune resilience, resists disease.

28 Apr 2025

Research uncovers the cellular culprit behind age-related abdominal fat

It's no secret that our waistlines often expand in middle-age, but the problem isn't strictly cosmetic. Belly fat accelerates aging and slows down metabolism, increasing our risk for developing diabetes, heart problems and other chronic diseases.

25 Apr 2025

Network pharmacology analysis reveals HXTL mechanism in treating postmenopausal osteoporosis

Huo Xue Tong Luo Capsule (HXTL) has been clinically used to treat osteonecrosis of the femoral head, osteoporosis, and other bone and joint diseases with promising effects.

24 Apr 2025

Manipulating a master regulator prevents tumor growth in mice

A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system's response to cancer.

24 Apr 2025

Common pinworm treatment may halt and reverse cancer growth in Merkel cell carcinoma

A common pinworm medication may stop and reverse cancer growth in Merkel cell carcinoma, an aggressive form of skin cancer, according to research led by University of Arizona Cancer Center researchers and published in the Journal of Clinical Investigation.

18 Apr 2025

Study examines how COX-2 regulates ferroptosis in chronic liver injury

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. +

18 Apr 2025

Novel strategy for treating acute myelogenous leukemia identified

A Ludwig Cancer Research study has identified a novel strategy for treating acute myelogenous leukemia (AML), an aggressive blood cancer for which the median survival time following diagnosis remains just 8.5 months.

16 Apr 2025

New hope for sclerosteosis patients through Wnt pathway inhibition

Sclerosteosis arises from mutations in the SOST gene, causing abnormally high bone mass and skeletal overgrowth, which can lead to severe health issues such as hearing loss and increased intracranial pressure.

16 Apr 2025

What happens if you significantly increase dietary folic acid intake?

Increased dietary folic acid intake may lead to adverse health effects, including inflammation and neurotoxicity, highlighting the need for optimal levels.

9 Apr 2025

QRICH1 protein discovery opens new avenues for cancer and autoimmune therapies

In a study of the immune systems of mice, scientists at Johns Hopkins Medicine say they have found a new role for a protein, QRICH1, which could become a target for drugs to dial up or down the activation of T cells to fight cancers and autoimmune diseases.

9 Apr 2025