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CATT study clarifies value of genetic testing for age-related macular degeneration

New findings from a landmark clinical trial show that although certain gene variants may predict whether a person is likely to develop age-related macular degeneration (AMD), a potentially blinding eye disease that afflicts more than nine million Americans, these genes do not predict how patients will respond to Lucentis- and Avastin-, the two medications most widely used to treat the "wet" form of AMD.

13 Feb 2013

Growth factor aids mandible reconstruction

Surgeons have used recombinant human bone morphogenetic protein-2 to successfully restore mandibulectomy defects with few adverse effects.

12 Feb 2013

Berkeley Lab researchers resolve EGFR activation mystery

Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

12 Feb 2013

Blood vessels play an important role in preventing spread of tumour cells

A lack of the protein endoglin in the blood vessels of tumour-bearing mice enables the spread of daughter tumours, according to researchers at Karolinska Institutet and Lund University in Sweden in a study published in the scientific periodical The Journal of Experimental Medicine. Given that the tumour vasculature constitutes an important barrier to the spread of cancer cells, the team suggests that drugs should be developed to strengthen the blood vessels' protective function.

12 Feb 2013

Researchers identify miR-506 as potential therapeutic candidate for metastatic ovarian cancer

Researchers employed an extensive analysis of genomic information to identify a new, high-risk cohort of ovarian cancer patients, characterize their tumors, find a potential treatment and test it in mouse models of the disease.

11 Feb 2013

Combination of two antibodies prevents growth and spread of triple-negative breast tumors

Cancer drugs of the new, molecular generation destroy malignant breast tumors in a targeted manner: They block characteristic molecules on tumor cells - receptors for the hormones estrogen or progesterone, or a co-receptor, called HER2, that binds to many growth factors. But about one in every six breast tumors has none of these receptors. Such cancers, called triple-negative, are particularly aggressive and notoriously difficult to treat.

10 Feb 2013

Positive results from NCI-sponsored bevacizumab trial on cervical cancer

Patients with advanced, recurrent, or persistent cervical cancer that was not curable with standard treatment who received the drug bevacizumab (Avastin) lived 3.7 months longer than patients who did not receive the drug, according to an interim analysis of a large, randomized clinical trial.

10 Feb 2013

Intravitreal ranibizumab shows little benefit after hemorrhage

Ranibizumab given intravitreally offers no clear benefit in the treatment of vitreous hemorrhage due to proliferative diabetic retinopathy, a randomized clinical trial indicates.

8 Feb 2013

Study finds two biomarkers of acute kidney injury

Acute kidney injury strikes large numbers of hospitalized patients, including those with no prior kidney-related illness, and is one of the most costly and deadly conditions affecting critically ill patients.

7 Feb 2013

Paternal obesity may alter genetic mechanisms in next generations

A father's obesity is one factor that may influence his children's health and potentially raise their risk for diseases like cancer, according to new research from Duke Medicine.

6 Feb 2013

Acceleron commences dalantercept phase 2 study in metastatic renal cell carcinoma

Acceleron Pharma, Inc., a biopharmaceutical company developing protein therapeutics for cancer and orphan diseases, announced the initiation of a phase 2 study of dalantercept, a novel angiogenesis inhibitor that targets the activin receptor-like kinase 1 (ALK1) pathway.

5 Feb 2013

Epidermal growth factor speeds recovery of blood-making stem cells after radiation exposure

Epidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could open new options for treating cancer patients and victims of dirty bombs or nuclear disasters.

3 Feb 2013

Potential connection between autism and insulin-like growth factor

A New York-based physician-researcher from Touro College of Osteopathic Medicine, best known for his research into fertility and twinning, has uncovered a potential connection between autism and a specific growth protein that could eventually be used as a way to predict an infant's propensity to later develop the disease.

2 Feb 2013

Clarient adopts QIAGEN’s therascreen KRAS test to diagnose colorectal cancer

QIAGEN N.V. today announced that Clarient - a GE Healthcare Company and leading provider of cancer laboratory testing services in the United States - has adopted the use of the therascreen KRAS RGQ PCR Kit (therascreen KRAS test) as a companion diagnostic to guide the use of Erbitux (cetuximab) as a treatment in patients with metastatic colorectal cancer.

From QIAGEN Manchester Limited 30 Jan 2013

NRC, AvidBiologics partner to develop three novel ADCs for treatment of cancer

AvidBiologics Inc., a life sciences company developing antibody-drug conjugates (ADCs), announces the conclusion of an agreement with the National Research Council Canada (NRC) to develop three novel ADCs for the treatment of cancer.

30 Jan 2013

Stem cells from bone marrow or fat improve recovery after stroke in rats

Stem cells from bone marrow or fat improve recovery after stroke in rats, finds a study published in BioMed Central's open access journal Stem Cell Research & Therapy. Treatment with stem cells improved the amount of brain and nerve repair and the ability of the animals to complete behavioural tasks.

29 Jan 2013

Study shows how GATA3 protein acts downstream biochemically to prevent breast cancer metastasis

The spread of breast cancer to distant organs within the body, an event that often leads to death, appears in many cases to involve the loss of a key protein, according to UC San Francisco researchers, whose new discoveries point to possible targets for therapy.

28 Jan 2013

UB scientists propose first genomic explanation for schizophrenia

New University at Buffalo research demonstrates how defects in an important neurological pathway in early development may be responsible for the onset of schizophrenia later in life.

23 Jan 2013

ELTD1 biomarker may help diagnose glioma

Researchers using sophisticated genetic testing techniques have identified a promising new biomarker for diagnosis of glioma—the most common type of malignant brain tumor, reports the January issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

17 Jan 2013

Eyes also need light to develop normally during pregnancy

New research in Nature concludes the eye – which depends on light to see – also needs light to develop normally during pregnancy.

17 Jan 2013

Growth Factor News and Research

CATT study clarifies value of genetic testing for age-related macular degeneration

Growth factor aids mandible reconstruction

Berkeley Lab researchers resolve EGFR activation mystery

Blood vessels play an important role in preventing spread of tumour cells

Researchers identify miR-506 as potential therapeutic candidate for metastatic ovarian cancer

Combination of two antibodies prevents growth and spread of triple-negative breast tumors

Positive results from NCI-sponsored bevacizumab trial on cervical cancer

Intravitreal ranibizumab shows little benefit after hemorrhage

Study finds two biomarkers of acute kidney injury

Paternal obesity may alter genetic mechanisms in next generations

Acceleron commences dalantercept phase 2 study in metastatic renal cell carcinoma

Epidermal growth factor speeds recovery of blood-making stem cells after radiation exposure

Potential connection between autism and insulin-like growth factor

Clarient adopts QIAGEN’s therascreen KRAS test to diagnose colorectal cancer

NRC, AvidBiologics partner to develop three novel ADCs for treatment of cancer

Stem cells from bone marrow or fat improve recovery after stroke in rats

Study shows how GATA3 protein acts downstream biochemically to prevent breast cancer metastasis

UB scientists propose first genomic explanation for schizophrenia

ELTD1 biomarker may help diagnose glioma

Eyes also need light to develop normally during pregnancy

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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