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MUHC researchers identify first genetic resistance factor against TB infection

Why do some people who are exposed to tuberculosis not become infected or develop the disease? Dr. Erwin Schurr and his team at the Research Institute from the McGill University Health Centre (RI-MUHC), in collaboration with Dr. Alexandre Alcais, from the Institut national de la sant- et de la recherche m-dicale (INSERM) in Paris, has shed light on this question for the first time. Their

2 Dec 2009

Universal Access and Human Rights: A central theme for World AIDS Day 2009

More than 33.4 million people are living with HIV/AIDS in the world today with 2.7 million new infections occurring each year. FHSSA reports, Sub-Saharan Africa is unequally impacted by HIV/AIDS, with 71% of new infections each year.

2 Dec 2009

Missouri scientists discover aspirin and Tylenol can inhibit vaccine efficacy

With flu season in full swing and the threat of H1N1 looming, demand for vaccines is at an all-time high. Although those vaccines are expected to be effective, University of Missouri researchers have found further evidence that some over-the-counter drugs, such as aspirin and Tylenol, that inhibit certain enzymes could impact the effectiveness of vaccines.

1 Dec 2009

Sperm genes may have a detrimental effect on longevity, says new study

Researchers in Japan have found that female mice produced by using genetic material from two mothers but no father live significantly longer than mice with the normal mix of maternal and paternal genes. Their findings provide the first evidence that sperm genes may have a detrimental effect on lifespan in mammals.

1 Dec 2009

New form of pathogen becomes a healthcare challenge in Africa

Research shows how a new, more deadly strain of Salmonella emerged over an 18-month period. Becoming resistant to antibiotics, acquiring the ability to spread from person to person and losing genes along the way, the new strain has become a healthcare challenge in Africa, killing up to one in four patients.

1 Dec 2009

Department of Health reminds Pennsylvanians to be tested regularly for HIV

In recognition of World AIDS Day on Dec. 1, Department of Health Secretary Everette James today reminded Pennsylvanians to be tested regularly for HIV - the virus that causes AIDS.

1 Dec 2009

DFG approves establishment of new CRCs; research topics range from modern prostheses to political reforms to marine bacteria

The DFG has approved the establishment of 17 new Collaborative Research Centres as of 1 January 2010. This decision was made recently by the relevant Grants Committee in Bonn.

1 Dec 2009

Amgen to present updated data on Nplate at the 2009 ASH meeting

Amgen Inc. today announced that it will present updated long-term safety and efficacy data for Nplate® (romiplostim) in adult chronic immune (idiopathic) thrombocytopenic purpura (ITP). Additionally, Amgen will present the first Nplate study in a pediatric setting as well as in patients with myelodysplastic syndromes (MDS) at the 2009 American Society of Hematology (ASH) Annual Meeting and Exposition (Dec. 5 - 8, 2009).

1 Dec 2009

Research shows link between nervous and immune systems; findings may lead to new treatments for autoimmune disorders

New research in the Journal of Leukocyte Biology shows the link between the nervous and immune systems and how breaking that link might lead to new treatments for a wide range of autoimmune disorders

1 Dec 2009

Researchers devise a way to deliver right therapy directly to tumors using aptamers

Finding and treating a tumor without disturbing normal tissue presents challenges - sometimes the most effective therapies can be invasive and harsh.

1 Dec 2009

European Patent Office grants patent EP1392642 for 4SC AG's lead auto-immune compound

4SC AG, a drug discovery and development company, today announced that the European Patent Office has granted patent EP1392642, which covers its lead auto-immune compound 4SC-101.

1 Dec 2009

Members of priority groups to receive H1N1 vaccines from Department of Health

The Department of Health reminded Pennsylvanians they can begin making appointments today to be vaccinated against the H1N1 flu virus.

1 Dec 2009

University of Navarra Hospital launches clinical trials to assess the efficacy of immunotherapy treatment

The University of Navarra Hospital has launched a series of clinical trials in order to assess the efficacy of an immunotherapy treatment. This approach involves the application of personalised vaccines -produced from healthy and tumour cells from the patient him or herself- and designed to combat glioblastomas, one of the most aggressive and frequent malignant tumours.

1 Dec 2009

Phase 1 study of preventive HIV vaccine testing a novel delivery mechanism completed

A Phase 1 study of a preventive HIV vaccine testing a novel delivery mechanism known as electroporation – the use of electrical pulses to increase the immune responses elicited by DNA vaccines – was recently completed in New York City.

1 Dec 2009

WHO issues new HIV/AIDS treatment guidelines

The WHO on Monday issued new recommendations that patients living with HIV/AIDS begin receiving antiretrovirals (ARVs) earlier than current HIV treatment advice suggests, the Associated Press reports

1 Dec 2009

Reductionist model provides new insights on HIV infection

A major obstacle to HIV research is the virus's exquisite specialisation for its human host - meaning that scientists' traditional tools, like the humble lab mouse, can deliver only limited information. Now, a team of researchers writing in BioMed Central's open access Journal of Biology have made an ingenious assault on this problem by creating a mouse that has key features of HIV infection without being infected with HIV.

1 Dec 2009

Clinical trials of personalised vaccines to fight glioblastomas

The University of Navarra Hospital has launched a series of clinical trials in order to assess the efficacy of an immunotherapy treatment. This approach involves the application of personalised vaccines —produced from healthy and tumour cells from the patient him or herself— and designed to combat glioblastomas, one of the most aggressive and frequent malignant tumours.

30 Nov 2009

Tripep completes phase I clinical study of its ChronVac-C hepatitis C virus DNA vaccine

Inovio Biomedical Corporation, a leader in DNA vaccine design, development and delivery, announced today that its partner Tripep AB of Sweden has completed its phase I clinical study of its ChronVac-C hepatitis C virus DNA vaccine delivered using Inovio’s electroporation technology.

30 Nov 2009

NOVAVAX completes patient enrollment in its trivalent seasonal influenza VLP vaccine Phase II study

Novavax, Inc. announced today it has completed enrollment in the Phase II clinical study of its trivalent seasonal influenza (2008/2009 recommended strains) VLP vaccine candidate in healthy adults 60 years of age or older (older adults). This randomized, double-blind, active-controlled study is comparing the safety, tolerability and immunogenicity of two different doses (15 mcg and 60 mcg) of Novavax's trivalent seasonal influenza VLP vaccine to a commercially available trivalent inactivated vaccine, TIV (Fluzone®).

30 Nov 2009

Study provides new insight into the mechanism of bacterial invasion protein

Spoiled meat is one of the sources for Listeria infections leading to listeriosis. Pregnant women, newborns and immune compromised people are susceptible for a severe progression of this disease. Firstly, the pathogen breaches the intestinal barrier and thus enters the body. The key for further spreading is the invasion protein internalin B that is located on the bacterial surface.

30 Nov 2009

Immune System News and Research

MUHC researchers identify first genetic resistance factor against TB infection

Universal Access and Human Rights: A central theme for World AIDS Day 2009

Missouri scientists discover aspirin and Tylenol can inhibit vaccine efficacy

Sperm genes may have a detrimental effect on longevity, says new study

New form of pathogen becomes a healthcare challenge in Africa

Department of Health reminds Pennsylvanians to be tested regularly for HIV

DFG approves establishment of new CRCs; research topics range from modern prostheses to political reforms to marine bacteria

Amgen to present updated data on Nplate at the 2009 ASH meeting

Research shows link between nervous and immune systems; findings may lead to new treatments for autoimmune disorders

Researchers devise a way to deliver right therapy directly to tumors using aptamers

European Patent Office grants patent EP1392642 for 4SC AG's lead auto-immune compound

Members of priority groups to receive H1N1 vaccines from Department of Health

University of Navarra Hospital launches clinical trials to assess the efficacy of immunotherapy treatment

Phase 1 study of preventive HIV vaccine testing a novel delivery mechanism completed

WHO issues new HIV/AIDS treatment guidelines

Reductionist model provides new insights on HIV infection

Clinical trials of personalised vaccines to fight glioblastomas

Tripep completes phase I clinical study of its ChronVac-C hepatitis C virus DNA vaccine

NOVAVAX completes patient enrollment in its trivalent seasonal influenza VLP vaccine Phase II study

Study provides new insight into the mechanism of bacterial invasion protein

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