Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Study identifies an epigenetic regulator that suppresses pathogenic events in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterized by chronic inflammation of synovium, eventually leading to joint destruction. Epigenetic alteration (the mechanism of gene expression regulation without DNA sequence changes), such as low levels of DNA methylation, is one of the factors which worsens the RA state.

8 Jun 2022

Novel approach to drug repurposing incorporates two-stage prediction and machine learning

A new study presents a novel approach to drug repurposing that incorporates two-stage prediction and machine learning.

7 Jun 2022

Sarbecovirus pathogenesis regulated by a multitrait locus

In a recent study posted to the bioRxiv* preprint server, the authors demonstrated that the sarbecovirus pathogenesis was regulated by a multitrait locus.

7 Jun 2022

MIT researchers identify components of mucus that can inhibit fungal infections

Candida albicans is a yeast that often lives in the human digestive tract and mouth, as well as urinary and reproductive organs.

6 Jun 2022

New analytical method sheds light on enduring mystery about type 2 diabetes

Researchers at Oregon State University have invented a new analytical method that sheds light on an enduring mystery regarding type 2 diabetes: Why some obese patients develop the disease and others don't.

6 Jun 2022

Combinations of multiple genetic factors play a role in the broad spectrum of autism

Autism Spectrum Disorder (ASD) is referred to as a "spectrum" because clinical features of ASD range from mild social impairments in some people to severe intellectual disability or epilepsy in others.

3 Jun 2022

Brain motor and fear circuits orchestrate the immune response to acute stress

A new study explores how acute stressors affected mice in terms of their immune responses in specific regions of the brain.

2 Jun 2022

A non-coding RNA molecule regulates mitochondrial gene expression in human cells, study shows

A new study published in the journal Cell shows that a non-coding RNA molecule regulates mitochondrial gene expression in human cells.

2 Jun 2022

Cellular changes in astrocytes play a crucial role in regulating outcomes for CNS disorders

Investigators at Cedars-Sinai have comprehensively mapped molecular activity in the brain and spinal cord that is responsible for regulating the body's response to central nervous system (CNS) disorders such as Alzheimer's, Huntington's disease and spinal cord injuries.

2 Jun 2022

New findings by HBP researchers provide a better understanding of human brain organization

Specific cellular, molecular and gene expression patterns in brain areas are linked to function, but their precise relationships remain largely unknown.

2 Jun 2022

Stem cell model could provide insights into biological mechanisms that underlie neuropsychiatric disorders

Researchers from the Icahn School of Medicine at Mount Sinai have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia.

1 Jun 2022

Microgravity culture during spaceflight enhances microbial infection process in 3D intestinal models

Infectious microbes have evolved sophisticated means to invade host cells, outwit the body's defenses and cause disease.

1 Jun 2022

People with food allergies less likely to become infected with SARS-CoV-2, study finds

A National Institutes of Health-funded study has found that people with food allergies are less likely to become infected with SARS-CoV-2, the virus that causes COVID-19, than people without them. In addition, while previous research identified obesity as a risk factor for severe COVID-19, the new study has identified obesity and high body mass index (BMI) as associated with increased risk for SARS-CoV-2 infection.

1 Jun 2022

Researchers identify molecular characteristics linked to increased likelihood of post-vaccination fatigue

Despite their strong effectiveness against SARS-CoV-2, mRNA-based COVID-19 vaccines are associated with adverse post-vaccination effects, such as fatigue; how can this be avoided? In a new study publishing May 31st in the open-access journal PLOS Biology, Ayesa Syenina of the Duke–NUS Medical School in Singapore and colleagues report that a new analysis of blood samples from people vaccinated for COVID-19 has identified distinct molecular characteristics linked to an increased likelihood of post-vaccination fatigue.

31 May 2022

IOB's new scRNA-seq protocol provides a snapshot of the cell transcriptome at unprecedented resolution

Single-cell RNA-sequencing (scRNA-seq) shows which genes are turned on in a cell and what their level of transcription is. This allows in-depth assessment of the biology of individual cells, and detection of changes that may indicate disease.

31 May 2022

UCLA researchers discover key molecular mechanism behind memory linking

Our brains rarely record single memories - instead, they store memories into groups so that the recollection of one significant memory triggers the recall of others connected by time.

25 May 2022

Key immunological changes that support peanut allergy remission in children discovered

Australian researchers have discovered the key immunological changes that support the remission of peanut allergy in children, paving the way for new, more targeted treatments.

25 May 2022

Study unveils the novel driver of cardiomyocyte loss

Researchers from the group of Eva van Rooij used advanced sequencing technology to better understand the heart disease arrhythmogenic cardiomyopathy, in which heart muscle tissue is replaced by fat cells. Using explanted human hearts, they found regions in which heart muscle was actively degenerated and identified a new gene, ZBTB11, that drives heart muscle cell degradation. The results were published in Cardiovascular Research on 17 May 2022.

25 May 2022

Study reveals how processes in the human body could turn harmless immune cells into ruthless killers

Processes in the human body could turn groups of harmless immune cells into ruthless killers, capable of attacking other cells infected with viruses or parasites, and potentially tumor cells, a new study reveals.

24 May 2022

SARS-CoV-2 mRNA vaccines do not stimulate interferon stimulatory gene expression in Aicardi Goutières Syndrome patients

A new study aimed to evaluate the immunostimulatory potential of mRNA vaccines in AGS patients.

23 May 2022

Gene Expression News and Research

Further Reading

Study identifies an epigenetic regulator that suppresses pathogenic events in rheumatoid arthritis

Novel approach to drug repurposing incorporates two-stage prediction and machine learning

Sarbecovirus pathogenesis regulated by a multitrait locus

MIT researchers identify components of mucus that can inhibit fungal infections

New analytical method sheds light on enduring mystery about type 2 diabetes

Combinations of multiple genetic factors play a role in the broad spectrum of autism

Brain motor and fear circuits orchestrate the immune response to acute stress

A non-coding RNA molecule regulates mitochondrial gene expression in human cells, study shows

Cellular changes in astrocytes play a crucial role in regulating outcomes for CNS disorders

New findings by HBP researchers provide a better understanding of human brain organization

Stem cell model could provide insights into biological mechanisms that underlie neuropsychiatric disorders

Microgravity culture during spaceflight enhances microbial infection process in 3D intestinal models

People with food allergies less likely to become infected with SARS-CoV-2, study finds

Researchers identify molecular characteristics linked to increased likelihood of post-vaccination fatigue

IOB's new scRNA-seq protocol provides a snapshot of the cell transcriptome at unprecedented resolution

UCLA researchers discover key molecular mechanism behind memory linking

Key immunological changes that support peanut allergy remission in children discovered

Study unveils the novel driver of cardiomyocyte loss

Study reveals how processes in the human body could turn harmless immune cells into ruthless killers

SARS-CoV-2 mRNA vaccines do not stimulate interferon stimulatory gene expression in Aicardi Goutières Syndrome patients

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