Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

Spike ferritin nanoparticles show potential as SARS-CoV-2 vaccine

Now, a new study published on the preprint server bioRxiv* in August 2020 reports the induction of neutralizing antibodies in mice by a single dose of a ferritin nanoparticle-based vaccine containing the spike protein.

1 Sep 2020

$Sacubitril/valsartan therapy may reduce hospitalization in heart patients with preserved ejection fraction$

Sacubitril/valsartan therapy may reduce hospitalization in heart patients with preserved ejection fraction

Sacubitril/valsartan reduces NT-proBNP, a biomarker predictive of long-term clinical outcomes in heart failure, but does not improve functional capacity compared to individualized background therapy in patients with heart failure with preserved ejection fraction

1 Sep 2020

Scientists explain why SARS-CoV-2 targets multiple organs

Now, a team of researchers at LSU Health New Orleans’ Neuroscience Center of Excellence and School of Medicine has explained the gateway receptor for SARS-CoV-2 and how it leads to the emergence of many complications as it targets many parts of the body.

31 Aug 2020

COVID-19 patients may experience long-term cardiovascular complications

Researchers at the University of Washington in Seattle have conducted a study suggesting that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect heart tissue and contribute to whole-organ cardiac dysfunction.

31 Aug 2020

SGLT2 inhibitors can slow CKD progression

850 million people worldwide are affected by chronic kidney disease (CKD) - a worrying figure, and one that continues to rise.

31 Aug 2020

Antihypertensive drugs are not linked to cancer, shows study

There is no evidence that blood pressure lowering drugs increase the risk of cancer, according to the most extensive study conducted on the topic. The late breaking research is presented today at ESC Congress 2020.

31 Aug 2020

DAPA-CKD trial shows dapagliflozin reduces risk of chronic kidney disease

Dapagliflozin reduces the risk of kidney failure, death from cardiovascular causes or heart failure hospitalization and all-cause mortality in chronic kidney disease patients with or without type 2 diabetes.

31 Aug 2020

Premenopausal women have favorable long-term outcomes after heart attack, shows study

Premenopausal women have good long-term outcomes after a heart attack, according to late breaking research presented today at ESC Congress 2020.

31 Aug 2020

Rabbits susceptible to SARS-CoV-2: Red flag for potential virus reservoir

A new study by scientists in the Netherlands and published on the preprint server bioRxiv* in August 2020 shows that the severe acute respiratory coronavirus-2 (SARS-CoV-2) can infect rabbits, which opens the door for possible circulation in rabbit farms and another potential source of animal to human SARS-CoV-2 infection. This finding calls for urgent research on the prevalence of the virus in farmed rabbits.

30 Aug 2020

Study may help explain the symptoms and organs involved with SARS-CoV-2 infection

A study of a gateway receptor for SARS-CoV-2 led by Walter Lukiw, PhD, Professor of Neuroscience, Neurology and Ophthalmology at LSU Health New Orleans' Neuroscience Center of Excellence and School of Medicine, may help explain the wide variety of symptoms and organs involved with SARS-CoV-2 infection and COVID-19.

28 Aug 2020

Study shows furin cleavage site is crucial for SARS-CoV-2 replication

In a recent bioRxiv* preprint paper, researchers from the United States demonstrate the pivotal role the furin cleavage site insertion in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein plays in viral replication and pathogenesis – highlighting, in turn, the need for mutation monitoring when developing therapeutics and vaccines.

27 Aug 2020

Study: Estrogen may reduce severity of COVID-19 symptoms in women

Why are men at greater risk than women for more severe symptoms and worse outcomes from COVID-19 regardless of age?

27 Aug 2020

First lethal mouse model of SARS-CoV-2 developed

Army scientists have developed the first lethal mouse model of SARS-CoV-2, the virus that causes COVID-19, using mice that were genetically engineered to express the human ACE2 gene--a key mechanism by which the virus enters human cells.

27 Aug 2020

Estradiol appears to help in female SARS-CoV-2 infection

A new study published on the preprint server medRxiv in August 2020 shows that the risk of infection is high for pre-menopausal women but the risk of death is much higher for men in the same age group and throws light on the protective nature of estradiol therapy in post-menopausal women.

26 Aug 2020

Inhaled steroids reduce SARS-CoV-2-related genes in COPD

A new study published on the preprint server medRxiv* aims to explore the effects of treatment with ICS on the expression of specific genes related to SARS-CoV-2 infection in bronchial epithelial cells in a prospective interventional design.

25 Aug 2020

Antihypertensives reduce severity of Covid-19 infection and death

Medication for high blood pressure could improve Covid-19 survival rates and reduce the severity of infection - according to new research from the University of East Anglia.

25 Aug 2020

Single dose nasal vaccine against SARS-CoV-2 shows promise in animal studies

Now researchers at the Washington University School of Medicine in St. Louis have worked on developing a candidate vaccine against the infection that could be administered in a single dose via a nasal spray rather than an injection. In their preliminary studies using lab mice, this single dose of the nasal vaccine successfully prevented the infection with the novel coronavirus.

24 Aug 2020

Genomic analysis reveals many animal species vulnerable to SARS-CoV-2

Now, a new genomics study by University of California, Davis, California researchers identifies a large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins.

24 Aug 2020

Ferrets not susceptible to SARS-CoV-2 infection

A recent study by scientists at the Cummings School of Veterinary Medicine at Tufts University has revealed that ferrets are not susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection even if they are directly exposed to symptomatic coronavirus disease 2019 (COVID-19) patients for a prolonged time.

24 Aug 2020

A better understanding of SARS-CoV-2 in children

Researchers at Duke University School of Medicine in Durham, North Carolina, have conducted a study showing that Hispanic ethnicity is associated with an increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children.

24 Aug 2020