Genomic News and Research

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Unraveling the biology of senescent cells and healthy aging

Multiple researchers at the Jackson Laboratory are taking part in an ambitious research program spanning several top research institutions to study senescent cells.

29 Dec 2022

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.

28 Dec 2022

A genome-based comparison of SARS-CoV-2 XBB recombinant and its parental lineage

In a recent study posted to the bioRxiv* preprint server, researchers in Italy performed a genome-based comparison of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB recombinant with its parental lineages.

27 Dec 2022

New software accurately infers continental ancestry from tumor DNA and RNA

Could knowing where your ancestors came from be the key to better cancer treatments? Maybe, but where would that key fit? How can we trace cancer's ancestral roots to modern-day solutions?

27 Dec 2022

Study shows de novo origination of functional microproteins

In a new study, researchers performed a genomic analysis to investigate the origination of human microproteins of biological importance.

23 Dec 2022

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers.

22 Dec 2022

Virologists measure the level of herd immunity to hepatitis A virus

RUDN University virologists measured the level of herd immunity to hepatitis A virus in different regions of Russia.

22 Dec 2022

Brazilian model for COVID-19 vaccination reduced severe case and mortality even from variants

A study conducted in Serrana, a small town in São Paulo state used as a model for COVID-19 vaccination in Brazil, shows that mass vaccination reduced the severe case and death rates even while the gamma and delta variants were circulating.

21 Dec 2022

Huge multi-omic data analysis deciphers colorectal cancer genetics

An analysis of more than 100,000 colorectal cancer cases and 154,000 healthy controls published in Nature Genetics uncovered hundreds of signals that may serve as new treatment and prevention targets.

21 Dec 2022

Probiotic bacterium prevents neurodegeneration in animal model of ALS

A probiotic bacterium called Lacticaseibacillus rhamnosus HA-114 prevents neurodegeneration in the C. elegans worm, an animal model used to study amyotrophic lateral sclerosis (ALS).

20 Dec 2022

MGI’s DNBSEQ-T7* facilitates ultra-deep sequencing of high-complexity metagenomic samples

Thanks to high-throughput sequencing technologies, shotgun metagenomic methods were made possible and had effectively transformed microbiology. Today, advances in both short- and long-read technologies are overcoming many of the previous challenges affecting metagenomic profiling, especially of highly complex samples and environment.

From MGI 20 Dec 2022

MGI’s DNBSEQ-T7* recognized for its ultra-high throughput and excellent accuracy

Thanks to high-throughput sequencing technologies, shotgun metagenomic methods were made possible and had effectively transformed microbiology.

19 Dec 2022

New insights into biophysical origins of the genome's organization inside the cell nucleus

A team of scientists has uncovered the physical principles - a series of forces and hydrodynamic flows - that help ensure the proper functioning of life's blueprint.

19 Dec 2022

First cell-type specific multiomic study of the HIV brain

Researchers identify cell-type-specific differences in HIV integration sites in the brain.

19 Dec 2022

Study uncovers genetic cause of a novel developmental epilepsy syndrome

Neurodevelopmental disorders (NDD) encompass highly prevalent conditions such as autism and epilepsy, with cognitive disabilities alone affecting 1-3% of the global population.

16 Dec 2022

ACMG's new guideline strongly recommends the use of noninvasive prenatal screening for fetal chromosome abnormalities

The American College of Medical Genetics and Genomics (ACMG) has released a new Evidence-Based Clinical Practice Guideline (EBG), "Noninvasive prenatal screening for fetal chromosome abnormalities in a general-risk population: An evidence-based clinical guideline of the American College of Medical Genetics and Genomics."

16 Dec 2022

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Researchers investigated the cellular tropism, replication competence, persistence and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, and associated histopathological changes in infected tissues.

16 Dec 2022

NEJM study shows hidden genetic anomaly behind common late-onset cerebellar ataxia

Researchers at the University of Miami Miller School of Medicine, McGill University and other institutions have found that a well-concealed genetic variation in the gene FGF14, called a DNA tandem repeat expansion, causes a common form of late-onset cerebellar ataxia, a brain disorder that interferes with coordinated movement.

16 Dec 2022

Landmark population health study could pave the way for better tools to fight chronic diseases in Asian populations

The Lee Kong Chian School of Medicine at Nanyang Technological University, Singapore, in collaboration with other healthcare institutions here, has embarked on a landmark comprehensive population health study of 100,000 Singaporeans over a few decades to identify the social, environmental, lifestyle, and genetic factors associated with diseases prevalent in Singapore, such as diabetes, hypertension, and cancer.

16 Dec 2022

New mutations near known genes could contribute to the increase in cleft lip and palate risk

Cleft lip and palate are among the most common congenital malformations, which are mainly due to genetic causes.

16 Dec 2022

Genomic News and Research

Unraveling the biology of senescent cells and healthy aging

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

A genome-based comparison of SARS-CoV-2 XBB recombinant and its parental lineage

New software accurately infers continental ancestry from tumor DNA and RNA

Study shows de novo origination of functional microproteins

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

Virologists measure the level of herd immunity to hepatitis A virus

Brazilian model for COVID-19 vaccination reduced severe case and mortality even from variants

Huge multi-omic data analysis deciphers colorectal cancer genetics

Probiotic bacterium prevents neurodegeneration in animal model of ALS

MGI’s DNBSEQ-T7* facilitates ultra-deep sequencing of high-complexity metagenomic samples

MGI’s DNBSEQ-T7* recognized for its ultra-high throughput and excellent accuracy

New insights into biophysical origins of the genome's organization inside the cell nucleus

First cell-type specific multiomic study of the HIV brain

Study uncovers genetic cause of a novel developmental epilepsy syndrome

ACMG's new guideline strongly recommends the use of noninvasive prenatal screening for fetal chromosome abnormalities

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

NEJM study shows hidden genetic anomaly behind common late-onset cerebellar ataxia

Landmark population health study could pave the way for better tools to fight chronic diseases in Asian populations

New mutations near known genes could contribute to the increase in cleft lip and palate risk

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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