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New Histone Antibody Specificity Database allows scientists to find right antibodies for biomedical research

For years, a crisis has been brewing in molecular biology. The problem is that antibodies--research tools used to identify key proteins at work in a cell--aren't always what they seem. Unreliable antibodies have led to numerous instances of false findings, failed experiments, and wasted money and samples.

24 Jul 2015

Study points to potential treatment for thrombotic thrombocytopenic purpura

A rare autoimmune disease creates sudden pain in the abdomen or the head, sending a patient to the emergency room with a potentially fatal condition. The pain comes from a multitude of blockages of tiny blood vessels, formed after the patient's own immune system somehow inhibits an enzyme that is vital to control clotting.

23 Jul 2015

New TCR therapy demonstrates encouraging clinical responses in patients with multiple myeloma

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).

22 Jul 2015

Study identifies new culprit in Alzheimer's disease development

A recent study conducted at Nathan S. Kline Institute for Psychiatric Research and NYU Langone Medical Center implicates a new culprit in Alzheimer's disease development. The research reveals that ßCTF -- the precursor of the amyloid beta (Aß) peptide -- acts at the earliest stage of Alzheimer's to initiate a range of abnormalities leading to the loss of groups of neurons critical for memory formation.

22 Jul 2015

Adaptimmune’s NY-ESO-1 TCR-engineered T-cell therapy mediates sustained antitumor effects in multiple myeloma patients

Adaptimmune Therapeutics plc, a clinical stage biopharmaceutical company focused on the use of T-cell therapy to treat cancer, today announced that data from its Phase I/II study of its affinity enhanced T-cell receptor therapeutic targeting the NY-ESO-1 cancer antigen in patients with multiple myeloma has been published in Nature Medicine.

22 Jul 2015

Study reveals potential new therapeutic target for depression treatment

Increasing the levels of a signaling molecule found in the brain can positively alter response to stress, revealing a potential new therapeutic target for treatment of depression, UT Southwestern Medical Center researchers said.

22 Jul 2015

Alefacept drug offers clinical benefit to certain individuals with new-onset type 1 diabetes

Individuals with new-onset type 1 diabetes who took two courses of alefacept (Amevive®, Astellas Pharma Inc.) soon after diagnosis show preserved beta cell function after two years compared to those who received a placebo.

21 Jul 2015

MetLife Foundation Awards for Medical Research presented at AAIC 2015

At the Alzheimer's Association International Conference 2015 in Washington D.C., MetLife Foundation presented its annual MetLife Foundation Awards for Medical Research. These awards were presented to Randall Bateman, M.D., and Christian Haass, Ph.D., for their contributions in advancing Alzheimer's disease research.

21 Jul 2015

Protagonist Therapeutics closes $40 million Series C financing

Protagonist Therapeutics, Inc., a company developing novel, orally stable peptide therapeutics for gastrointestinal diseases and disorders, today announced the closing of a $40 million Series C financing.

16 Jul 2015

Elsevier, NCI implement two-way linking between research articles on ScienceDirect and datasets in caNanoLab

Elsevier, a world-leading provider of scientific, technical and medical information products and services, and the US National Cancer Institute, a world-leading institute for cancer research, today announced that they have implemented two-way linking between research articles on ScienceDirect and datasets stored in NCI's cancer Nanotechnology Laboratory (caNanoLab) data portal.

9 Jul 2015

EvoRx Technologies, AstraZeneca successfully complete research collaboration

AstraZeneca and EvoRx Technologies successfully completed a one-year research collaboration leveraging EvoRx's proprietary Evo-Link technology to discover cell penetrating peptides for a high value intracellular protein–protein interaction target in the respiratory portfolio.

9 Jul 2015

Johns Hopkins, IOCB Prague sign drug discovery research agreement

The Johns Hopkins Drug Discovery (JHDD) program, created with the mission of identifying novel drug targets arising from Johns Hopkins faculty research and translating them into new therapeutics, and the Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences (IOCB Prague) have entered into a five-year drug discovery research agreement to develop small-molecule and peptide drugs for a range of therapeutic areas including neurological diseases, cancer and gastrointestinal disorders.

9 Jul 2015

Allergan agrees to acquire exclusive worldwide rights to Merck's CGRP migraine development program

Allergan plc and Merck, known as MSD outside the United States and Canada, today announced that they have entered into an agreement under which Allergan will acquire the exclusive worldwide rights to Merck's investigational small molecule oral calcitonin gene-related peptide (CGRP) receptor antagonists, which are being developed for the treatment and prevention of migraine, subject to expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 (HSR).

7 Jul 2015

Using nanocarriers and microbubbles in drug delivery for treating thrombotic disease

Future Science Group today announced the publication of a new article in Future Science OA, covering the use of nanocarriers and microbubbles in drug delivery for thrombotic disease.

7 Jul 2015

NDSU's Stephen O'Rourke awarded NIH grant to conduct cardiovascular research

Stephen O'Rourke, professor of pharmaceutical sciences at North Dakota State University, Fargo, has received a $435,000 grant from the National Heart, Lung and Blood Institute of the National Institutes of Health to conduct cardiovascular research.

3 Jul 2015

Biologically active molecules produced during gluten digestion can pass through gut lining

Biologically active molecules released by digesting bread and pasta can survive digestion and potentially pass through the gut lining, suggests new research.

2 Jul 2015

dlDNA marks progression of HBV-related liver disease

The level of serum duplex-linear DNA increases markedly with liver disease progression and development of hepatocellular carcinoma in patients with chronic hepatitis B virus (HBV) infection, suggests research published in Gut.

30 Jun 2015

Spyryx receives award from Cystic Fibrosis Foundation to development therapeutic peptides for CF

Spyryx Biosciences, Inc., a privately-held biopharmaceutical company developing novel therapeutics for obstructive lung diseases, announced today it has received an award from Cystic Fibrosis Foundation Therapeutics, which will support development of Spyryx' therapeutic peptides for cystic fibrosis (CF).

26 Jun 2015

Different neurobiological pathways lead to expression of Alzheimer's disease

The amyloid cascade hypothesis of Alzheimer's disease (AD) posits that sticky aggregations or plaques of amyloid-beta peptides accumulate over time in the brain, triggering a series of events that ultimately result in the full-blown neurodegenerative disorder. The hypothesis has been a major driver of AD research for more than 20 years.

26 Jun 2015

Targeted molecular-imaging method could help identify early stages of prostate cancer

A targeted molecular-imaging method under development at Rochester Institute of Technology could help detect early stages of prostate cancer and improve image-directed biopsies.

23 Jun 2015

Peptides News and Research

New Histone Antibody Specificity Database allows scientists to find right antibodies for biomedical research

Study points to potential treatment for thrombotic thrombocytopenic purpura

New TCR therapy demonstrates encouraging clinical responses in patients with multiple myeloma

Study identifies new culprit in Alzheimer's disease development

Adaptimmune’s NY-ESO-1 TCR-engineered T-cell therapy mediates sustained antitumor effects in multiple myeloma patients

Study reveals potential new therapeutic target for depression treatment

Alefacept drug offers clinical benefit to certain individuals with new-onset type 1 diabetes

MetLife Foundation Awards for Medical Research presented at AAIC 2015

Protagonist Therapeutics closes $40 million Series C financing

Elsevier, NCI implement two-way linking between research articles on ScienceDirect and datasets in caNanoLab

EvoRx Technologies, AstraZeneca successfully complete research collaboration

Johns Hopkins, IOCB Prague sign drug discovery research agreement

Allergan agrees to acquire exclusive worldwide rights to Merck's CGRP migraine development program

Using nanocarriers and microbubbles in drug delivery for treating thrombotic disease

NDSU's Stephen O'Rourke awarded NIH grant to conduct cardiovascular research

Biologically active molecules produced during gluten digestion can pass through gut lining

dlDNA marks progression of HBV-related liver disease

Spyryx receives award from Cystic Fibrosis Foundation to development therapeutic peptides for CF

Different neurobiological pathways lead to expression of Alzheimer's disease

Targeted molecular-imaging method could help identify early stages of prostate cancer

Editorial Focus eBook - Peptides and Oligonucleotides (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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